NDLI: Protective Effects of <i>Cyperus Rotundus</i> Extract on Amyloid β-Peptide (1-40)-Induced Memory Impairment in Male Rats: A Behavioral Study.

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Protective Effects of Cyperus Rotundus Extract on Amyloid β-Peptide (1-40)-Induced Memory Impairment in Male Rats: A Behavioral Study.

Content Provider	Europe PMC
Author	Mehdizadeh, Mehdi Hashem Dabaghian, Fataneh Shojaee, Asie Molavi, Nima Taslimi, Zahra Shabani, Ronak Soleimani Asl, Sara
Copyright Year	2017
Abstract	Introduction:The Alzheimer Disease (AD) is the most common form of dementia that leads to memory impairment. As the oxidative stress plays an important role in AD pathogenesis, the current study aimed at examining the protective effects of Cyperus Rotundus as an antioxidant on amyloid β (Aβ)-induced memory impairment.Methods:Twenty-eight Wistar male rats received intrahippocampal (IHP) injection of the Aβ (1-40) and C. rotundus (400 mg/kg, intraperitoneally). Spatial memory was assessed by the Morris water-maze (MWM) task.Results:In the MWM, Aβ (1-40) significantly increased escape latency and traveled distance (P<0.001). The administration of C. rotundus attenuated the Aβ-induced memory impairment in the MWM task.Conclusion:The current study findings showed that C. Rotundus could improve the learning impairment, following the Aβ treatment, and it may lead to an improvement of AD-induced cognitive dysfunction.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5535330&blobtype=pdf
ISSN	2008126X
Journal	Basic and Clinical Neuroscience [Basic Clin Neurosci]
Volume Number	8
DOI	10.18869/nirp.bcn.8.3.249
PubMed Central reference number	PMC5535330
Issue Number	3
PubMed reference number	28781732
e-ISSN	22287442
Language	English
Publisher	Iranian Neuroscience Society
Publisher Date	2017-05-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright© 2017 Iranian Neuroscience Society
Subject Keyword	Alzheimer disease Amyloid β-peptide Cyperus rotundus Spatial memory
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Cellular and Molecular Neuroscience

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