NDLI: Studies of the Effects of Central Administration of β-Amyloid Peptide (25–35): Pathomorphological Changes in the Hippocampus and Impairment of Spatial Memory

Content Provider	Springer Nature Link
Author	Stepanichev, M. Yu. Zdobva, I. M. Zarubenko, I. I. Lazareva, N. A. Gulyaeva, N. V.
Copyright Year	2006
Abstract	The possible link between amnesia induced by central administration of β-amyloid (25–35) (Aβ(25–35)) and neurodegenerative changes in the hippocampus was studied. Male Wistar rats received single intracerebroventricular injections of Aβ(25–35) at a dose of 15 nmoles and one month later were trained in an eight-arm radial maze. Training was followed by histological assessment of the state of the hippocampus on brain sections stained with hematoxylin and eosin. Aβ(25–35) induced impairments in long-term (reference) and working memory on testing in the maze. There was a moderate reduction in the number of neurons in hippocampal field CA1; there was no change in the number of cells in field CA3. The numbers of errors made by the animals on testing in the maze were found to correlate negatively with the numbers of nerve cells in hippocampal field CA1. Thus, this is the first demonstration that impairments of learning and memory induced by single doses of Aβ(25–35) are specifically associated with neurodegenerative changes in hippocampal field CA1 in rats.
Starting Page	101
Ending Page	106
Page Count	6
File Format	PDF
ISSN	00970549
Journal	Neuroscience and Behavioral Physiology
Volume Number	36
Issue Number	1
e-ISSN	1573899X
Language	English
Publisher	Kluwer Academic Publishers-Consultants Bureau
Publisher Date	2006-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	amyloid-β(25–35) hippocampus CA1 memory neurodegeneration eight-arm maze Neurosciences Behavioural Sciences Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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