NDLI: Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas

Please wait, while we are loading the content...

Roles of carboxylate donors in O–O bond scission of peroxodi-iron(iii) to high-spin oxodi-iron(iv) with a new carboxylate-containing dinucleating ligand

Exciton recombination dynamics in nanoring cycloparaphenylenes

Zinc-seamed pyrogallol[4]arene dimers as structural components in a two-dimensional MOF

Electrochemical formation and reactivity of a manganese peroxo complex: acid driven H₂O₂ generation vs. O–O bond cleavage

Illuminating HIV gp120-ligand recognition through computationally-driven optimization of antibody-recruiting molecules

Construction of an orthogonal ZnSalen/Salophen library as a colour palette for one- and two-photon live cell imaging

Highly sensitive and selective detection of the pyrophosphate anion biomarker under physiological conditions

Pd(quinox)-catalyzed allylic relay Suzuki reactions of secondary homostyrenyl tosylates via alkene-assisted oxidative addition

Metal control of selectivity in acetate-assisted C–H bond activation: an experimental and computational study of heterocyclic, vinylic and phenylic C(sp²)–H bonds at Ir and Rh

A catalyst-controlled selective synthesis of pyridines and pyrroles

Non-directed allylic C–H acetoxylation in the presence of Lewis basic heterocycles

Formal hydrogenation of arynes with silyl C_β–H bonds as an active hydride source

Rapid, facile synthesis of conjugated polymer zwitterions in ionic liquids

Coordination-triggered NO release from a dinitrosyl iron complex leads to anti-inflammatory activity

Copper catalyzed direct alkenylation of simple alkanes with styrenes

Synthesis of diarylmethylamines via palladium-catalyzed regioselective arylation of 1,1,3-triaryl-2-azaallyl anions

Guest-dependent mechanical anisotropy in pillared-layered soft porous crystals – a nanoindentation study

Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas

5-(Methylthio)tetrazoles as versatile synthons in the stereoselective synthesis of polycyclic pyrazolines via photoinduced intramolecular nitrile imine–alkene 1,3-dipolar cycloaddition

Copper catalyzed Heck-like cyclizations of oxime esters

Selective radical amination of aldehydic C(sp²)–H bonds with fluoroaryl azides via Co(ii)-based metalloradical catalysis: synthesis of N-fluoroaryl amides from aldehydes under neutral and nonoxidative conditions

Boron–boron J coupling constants are unique probes of electronic structure: a solid-state NMR and molecular orbital study

Enantioselective direct α-alkylation of cyclic ketones by means of photo-organocatalysis

Addition of pnictogen atoms to chromium(ii): synthesis, structure and magnetic properties of a chromium(iv) phosphide and a chromium(iii) arsenide

Sequence-responsive unzipping DNA cubes with tunable cellular uptake profiles

Pattern-based sensing of aminoglycosides with fluorescent amphiphiles

Spin crossover iron(ii) complexes as PARACEST MRI thermometers

Phosphorus(v) tetraazaporphyrins: porphyrinoids showing an exceptionally strong CT band between the Soret and Q bands

Magnitude and consequences of OR ligand σ-donation on alkene metathesis activity in d⁰ silica supported (SiO)W(NAr)(CHtBu)(OR) catalysts

Phosphorescent nematic hydrogels and chromonic mesophases driven by intra- and intermolecular interactions of bridged dinuclear cyclometalated platinum(ii) complexes

The role of 5f-orbital participation in unexpected inversion of the σ-bond metathesis reactivity trend of triamidoamine thorium(iv) and uranium(iv) alkyls

Facile dissolution of selenium and tellurium in a thiol–amine solvent mixture under ambient conditions

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

Carbon–fluorine bond cleavage in fluoroarenes via a niobium(iii) imido complex: from stoichiometric to catalytic hydrodefluorination

Ambient condition oxidation in individual liposomes observed at the single molecule level

Detecting intracellular translocation of native proteins quantitatively at the single cell level

Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(ii) organometallics

Multiple metal-bound oligomers from Ir-catalysed dehydropolymerisation of H₃B·NH₃ as probed by experiment and computation

Aqueous solubilization of hydrophobic supramolecular metal–organic nanocapsules

Stimuli-induced folding cascade of a linear oligomeric guest chain programmed through cucurbit[n]uril self-sorting (n = 6, 7, 8)

Mapping electrogenerated chemiluminescence reactivity in space: mechanistic insight into model systems used in immunoassays

Tuning the electronic environment of cations and anions using ionic liquid mixtures

En route towards panchromatic light harvesting: photophysical and electrochemical properties of Bodipy–porphyrazine conjugates

Back cover

Chemical Science Vol - 5 Issue - 5

Chemical Science Vol - 5 Issue - 4

Chemical Science Vol - 5 Issue - 3

Chemical Science Vol - 5 Issue - 2

Chemical Science Vol -4

Chemical Science Vol -3

Chemical Science Vol -2

Chemical Science Vol -1

Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas

Content Provider	Royal Society of Chemistry (RSC)
Author	Rillahan, Cory D. Rangarajan, Janani Fokin, Valery V. Arlian, Britni M. He, Yuan Paulson, James C. Macauley, Matthew S. Schwartz, Erik McBride, Ryan
Copyright Year	2014
Abstract	The siglec family of sialic acid-binding proteins are endocytic immune cell receptors that are recognized as potential targets for cell directed therapies. CD33 and CD22 are prototypical members and are validated candidates for targeting acute myeloid leukaemia and non-Hodgkin's lymphomas due to their restricted expression on myeloid cells and B-cells, respectively. While nanoparticles decorated with high affinity siglec ligands represent an attractive platform for delivery of therapeutic agents to these cells, a lack of ligands with suitable affinity and/or selectivity has hampered progress. Herein we describe selective ligands for both of these siglecs, which when displayed on liposomal nanoparticles, can efficiently target the cells expressing them in peripheral human blood. Key to their identification was the development of a facile method for chemo-enzymatic synthesis of disubstituted sialic acid analogues, combined with iterative rounds of synthesis and rapid functional analysis using glycan microarrays.
Starting Page	2398
Ending Page	2406
Page Count	9
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	5
Issue Number	6
Journal	Chemical Science
DOI	10.1039/c4sc00451e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	SIGLEC Myeloid tissue Carboxylic acid Functional analysis Acute myeloid leukemia CD33 CD22 Glycan
Content Type	Text
Resource Type	Article
Subject	Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas.

Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas

Myeloid precursors and acute myeloid leukemia cells express multiple CD33-related Siglecs.

B Cell Siglecs–News on Signaling and Its Interplay With Ligand Binding

CD22 and Siglec-G regulate inhibition of B-cell signaling by sialic acid ligand binding and control B-cell tolerance

In vivo targeting of B-cell lymphoma with glycan ligands of CD22

LYMPHOID NEOPLASIA In vivo targeting of B-cell lymphoma with glycan ligands of CD22

Distinct endocytic mechanisms of cd22 (siglec-2) and siglec-f reflect roles in cell signaling and innate immunity (2007).

Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens

Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas

Similar Documents

Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas.

Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas

Myeloid precursors and acute myeloid leukemia cells express multiple CD33-related Siglecs.

B Cell Siglecs–News on Signaling and Its Interplay With Ligand Binding

CD22 and Siglec-G regulate inhibition of B-cell signaling by sialic acid ligand binding and control B-cell tolerance

In vivo targeting of B-cell lymphoma with glycan ligands of CD22

LYMPHOID NEOPLASIA In vivo targeting of B-cell lymphoma with glycan ligands of CD22

Distinct endocytic mechanisms of cd22 (siglec-2) and siglec-f reflect roles in cell signaling and innate immunity (2007).

Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens

Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas