NDLI: A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses <i>in vivo</i>

Please wait, while we are loading the content...

Solid-state structural transformation doubly triggered by reaction temperature and time in 3D metal-organic frameworks: great enhancement of stability and gas adsorption

Non-close-packed pore arrays through one-step breath figure self-assembly and reversal

Insight into aggregation-induced emission characteristics of red-emissive quinoline-malononitrile by cell tracking and real-time trypsin detection

Three-electron two-centred bonds and the stabilisation of cationic sulfur radicals

High-capacity Li₂S–graphene oxide composite cathodes with stable cycling performance

A tripodal peptide ligand for asymmetric Rh(ii) catalysis highlights unique features of on-bead catalyst development

Atomic properties and chemical bonding in the pyrite and marcasite polymorphs of FeS₂: a combined experimental and theoretical electron density study

Photoscopy: spectroscopic information from camera snapshots?

Hydrogen atom abstraction reactions independent of C–H bond dissociation energies of organic substrates in water: significance of oxidant–substrate adduct formation

A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo

Highly enantioselective S–H bond insertion cooperatively catalyzed by dirhodium complexes and chiral spiro phosphoric acids

Probing the mobility of catenane rings in single molecules

Theoretical study of the magnetic anisotropy and magnetic tunnelling in mononuclear Ni(ii) complexes with potential molecular magnet behavior

Highly efficient cycloreversion of photochromic dithienylethene compounds using visible light-driven photoredox catalysis

A light-induced reversible phase separation and its coupling to a dynamic library of imines

Nanoscale self-assembled multivalent (SAMul) heparin binders in highly competitive, biologically relevant, aqueous media

Computational prediction and experimental confirmation of B-site doping in YBa₂Fe₃O₈

Observation of the rare chrysene excimer

BiVO₄–Ru/SrTiO₃:Rh composite Z-scheme photocatalyst for solar water splitting

Tristable [n]rotaxanes: from molecular shuttle to molecular cable car

Iron-mediated intermolecular N-group transfer chemistry with olefinic substrates

Utilizing the bioorthogonal base-pairing system of l-DNA to design ideal DNA nanocarriers for enhanced delivery of nucleic acid cargos

NIR electrochemical fluorescence switching from polymethine dyes

Sodium phosphaethynolate, Na(OCP), as a “P” transfer reagent for the synthesis of N-heterocyclic carbene supported P₃ and PAsP radicals

Predicting pathways for terpene formation from first principles – routes to known and new sesquiterpenes

Evaluating atomic components in fluorene wires

Hierarchically tetramodal-porous zeolite ZSM-5 monoliths with template-free-derived intracrystalline mesopores

Palladium-catalyzed benzo[d]isoxazole synthesis by C–H activation/[4 + 1] annulation

Gold(iii) complexes inhibit growth of cisplatin-resistant ovarian cancer in association with upregulation of proapoptotic PMS2 gene

Catalytic enantioselective synthesis of 2-(2-hydroxyethyl)indole scaffolds via consecutive intramolecular amido-cupration of allenes and asymmetric addition of carbonyl compounds

Selective and reversible photochemical derivatization of cysteine residues in peptides and proteins

Engineered spatial inversion symmetry breaking in an oxide heterostructure built from isosymmetric room-temperature magnetically ordered components

Glycopolymers with secondary binding motifs mimic glycan branching and display bacterial lectin selectivity in addition to affinity

A series of C₃-symmetric heterobimetallic Cr–M (M = Fe, Co and Cu) complexes

Remarkable influence of secondary catalyst site on enantioselective desymmetrization of cyclopentenedione

A quantitative and site-specific chemoenzymatic glycosylation approach for PEGylated MUC1 peptides

Inhibition of the 4Fe–4S proteins IspG and IspH: an EPR, ENDOR and HYSCORE investigation

Modifying the properties of 4f single-ion magnets by peripheral ligand functionalisation

Inside back cover

Back cover

Chemical Science Vol - 5 Issue - 3

Chemical Science Vol - 5 Issue - 2

Chemical Science Vol -4

Chemical Science Vol -3

Chemical Science Vol -2

Chemical Science Vol -1

A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo

Content Provider	Royal Society of Chemistry (RSC)
Author	Reboulet, R. Savage, P. B. Deng, S. Bendelac, A. Teyton, L. Engler, D. A. Bai, L. Matthew, R.
Copyright Year	2014
Abstract	Due to the prevalence of oligo- and polysaccharides on the surfaces of pathogenic organisms, carbohydrates are primary targets for recognition by antibodies generated by the immune systems of higher organisms. Consequently, substantial effort has been expended in efforts to develop vaccines based on carbohydrate epitopes. Typical approaches involve multivalent presentation of carbohydrate targets on antigenic peptides or proteins, which often involve substantial synthetic commitments and/or vaccines that are heterogeneous and difficult to characterize. We have developed a simple, liposome-based approach to generate multivalent carbohydrate vaccines, and in place of an antigenic peptide or protein, we have used a potent antigen for natural killer T cells. This vaccine, based on the Streptococcus pneumoniae serotype 14 polysaccharide, gave a response superior to that from a clinically used vaccine (Prevnar). The dependence of this response on liposome formation was demonstrated by comparison to a simple mixture of the oligosaccharide and the natural killer T cell adjuvant. The importance of the strength of the adjuvant was observed by use of a potent synthetic adjuvant and a weaker, bacterial derived glycolipid adjuvant. These results demonstrate the effectiveness of this novel and relatively simple means of generating carbohydrate-based vaccines.
Starting Page	1437
Ending Page	1441
Page Count	5
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	5
Issue Number	4
Journal	Chemical Science
DOI	10.1039/c3sc53471e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Pneumococcal conjugate vaccine Natural killer T cell Antibody Oligosaccharide Liposome Vaccine Substance dependence Prevnar Protein Glycolipid Antigen Streptococcus Cytotoxic T cell Carbohydrate Adjuvant Serotype Peptide Polysaccharide
Content Type	Text
Resource Type	Article
Subject	Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo

Serotype-specific and age-dependent generation of pneumococcal polysaccharide-specific memory b-cell and antibody responses to immunization with a pneumococcal conjugate vaccine - (2007).

Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants

A Structural Model for the Ligand Binding of Pneumococcal Serotype 3 Capsular Polysaccharide-Specific Protective Antibodies.

Invasive Streptococcus pneumoniae in Children, Malawi, 2004–2006

Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine.

Immune response to octavalent diphtheria- and tetanus-conjugated pneumococcal vaccines is serotype- and carrier-specific: the choice for a mixed carrier vaccine.

Serotype distribution of Streptococcus pneumoniae and potential impact of pneumococcal conjugate vaccines in China: A systematic review and meta-analysis

a Pneumococcal Conjugate Vaccine Antibody Responses to Immunization with Polysaccharide-Specific Memory B-Cell and Generation of Pneumococcal Serotype-Specific and Age-Dependent

A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo

Similar Documents

A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo

Serotype-specific and age-dependent generation of pneumococcal polysaccharide-specific memory b-cell and antibody responses to immunization with a pneumococcal conjugate vaccine - (2007).

Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants

A Structural Model for the Ligand Binding of Pneumococcal Serotype 3 Capsular Polysaccharide-Specific Protective Antibodies.

Invasive Streptococcus pneumoniae in Children, Malawi, 2004–2006

Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine.

Immune response to octavalent diphtheria- and tetanus-conjugated pneumococcal vaccines is serotype- and carrier-specific: the choice for a mixed carrier vaccine.

Serotype distribution of Streptococcus pneumoniae and potential impact of pneumococcal conjugate vaccines in China: A systematic review and meta-analysis

a Pneumococcal Conjugate Vaccine Antibody Responses to Immunization with Polysaccharide-Specific Memory B-Cell and Generation of Pneumococcal Serotype-Specific and Age-Dependent

A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo