NDLI: Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants

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Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants

Content Provider	Scilit
Author	Kim, Sungjune Lalani, Saif Parekh, Vrajesh V. Wu, Lan Kaer, Luc Van
Copyright Year	2008
Description	Invariant natural killer T (iNKT) cells are a unique subset of T lymphocytes that recognize glycolipid antigens in the context of the antigen-presenting molecule CD1d. Upon glycolipid antigen stimulation, iNKT cells rapidly produce copious amounts of immunomodulatory cytokines, leading to potent activation of a variety of innate and adaptive immune cells. These immune-potentiating properties of iNKT cells hold great promise for the development of vaccine adjuvants. This review aims to summarize the immunomodulatory activities of iNKT cell ligands and to discuss prospects for developing iNKT cell-based vaccine adjuvants.
Related Links	http://europepmc.org/articles/pmc2680388?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680388/pdf
Ending Page	1532
Page Count	14
Starting Page	1519
ISSN	14760584
e-ISSN	17448395
DOI	10.1586/14760584.7.10.1519
Journal	Expert Review of Vaccines
Issue Number	10
Volume Number	7
Language	English
Publisher	Informa UK Limited
Publisher Date	2008-12-01
Access Restriction	Open
Subject Keyword	Α-galactosylceramide Adjuvant Antigen Presentation Glycolipid Innate Immunity Invariant Natural Killer T Cell
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology Immunology Molecular Medicine

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