NDLI: <i>In vivo</i> biodistribution of stable spherical and filamentous micelles probed by high-sensitivity SPECT

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In vivo biodistribution of stable spherical and filamentous micelles probed by high-sensitivity SPECT

Content Provider	Royal Society of Chemistry (RSC)
Author	Mendes, E. Marsman, I. J. C. Laan, A. C. Waton, G. Schosseler, F. Ivashchenko, O. Denkova, A. G. Beekman, F. J. Jennings, L.
Copyright Year	2016
Abstract	Understanding how nanoparticle properties such as size, morphology and rigidity influence their circulation time and biodistribution is essential for the development of nanomedicine therapies. Herein we assess the influence of morphology on cellular internalization, in vivo biodistribution and circulation time of nanocarriers using polystyrene-b-poly(ethylene oxide) micelles of spherical or elongated morphology. The glassy nature of polystyrene guarantees the morphological stability of the carriers in vivo and by encapsulating Indium-111 in their core, an assessment of the longitudinal in vivo biodistribution of the particles in healthy mice is performed with single photon emission computed tomography imaging. Our results show prolonged blood circulation, longer than 24 hours, for all micelle morphologies studied. Dynamics of micelle accumulation in the liver and other organs of the reticuloendothelial system show a size-dependent nature and late stage liver clearance is observed for the elongated morphology. Apparent contradictions between recent similar studies can be resolved by considering the effects of flexibility and degradation of the elongated micelles on their circulation time and biodistribution.
Starting Page	1202
Ending Page	1211
Page Count	10
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	4
Issue Number	8
Journal	Biomaterials Science
DOI	10.1039/c6bm00297h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Nanoparticle Liver Micelle Single-photon emission computed tomography Ethylene oxide Polystyrene Nanomedicine Mononuclear phagocyte system Indium-111
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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