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| Content Provider | IET Digital Library |
|---|---|
| Author | Ashraf, Ayesha Sharif, Rehana Ahmad, Munir Masood, Misbah Shahid, Abubakar Anjum, Dalaver H. Rafique, Muhammad Shahid Ghani, Sheeba |
| Abstract | Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran–AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran–AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc–AgNPs and 99mTc–dextran–AgNPs are mainly accumulated in liver/spleen region but 99mTc–dextran–AgNPs delayed recognition and uptake by liver. Results indicate that dextran–AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment. |
| Starting Page | 368 |
| Ending Page | 374 |
| Page Count | 7 |
| ISSN | 17518741 |
| Volume Number | 9 |
| e-ISSN | 1751875X |
| Issue Number | Issue 6, Dec (2015) |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/iet-nbt/9/6 |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2014.0075 |
| Journal | IET Nanobiotechnology |
| Publisher Date | 2015-12-01 |
| Access Restriction | Open |
| Rights Holder | © The Institution of Engineering and Technology |
| Subject Keyword | Biodistribution Analysis Biological Tissues Blood Cancer Coatings Dextran Coated AgNP Enhanced Blood Retention Time In Vivo Evaluation In Vivo Tissue Uptake Intravenously Administered-naked Functionalised Silver NanoParticle Liver Liver Cancer Treatment Liver-spleen Region Nanocomposite Nanofabrication Nanomedicine Nanoparticle Nanotechnology Application in Biomedicine Nuclear Medicine, Emission Tomography Organic Compound Patient Care And Treatment Patient Treatment Radiolabelling Reticuloendothelum System Silver Compound Silver NanoParticle Single Photon Emission Computed Tomography Single-photon Emission Computed Tomography Imaging Suspensions Water-based Suspension |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Biotechnology |
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