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Bioactive and biocompatible copper containing glass-ceramics with remarkable antibacterial properties and high cell viability designed for future in vivo trials

Correction: Powering up the molecular therapy of RNA interference by novel nanoparticles

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Biomaterials Science Vol - 4 Issue - 7

Biomaterials Science Vol - 4 Issue - 6

Biomaterials Science Vol - 4 Issue - 5

Biomaterials Science Vol - 4 Issue - 4

Biomaterials Science Vol - 4 Issue - 3

Biomaterials Science Vol - 4 Issue - 2

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Biomaterials Science Vol -2

Biomaterials Science Vol -1

Bioactive and biocompatible copper containing glass-ceramics with remarkable antibacterial properties and high cell viability designed for future in vivo trials

Content Provider	Royal Society of Chemistry (RSC)
Author	Todea, M. Ştefan, R. Voica, C. Popescu, R. A. Simon, S. Papuc, I. Magyari, K. Licarete, E. Trandafir, D. L. Vodnar, D. C. Vulpoi, A. Baia, L.
Copyright Year	2016
Abstract	In the present study our interest is focused on finding the efficiency of 60SiO2·(32 − x)CaO·8P2O5·xCuO (mol%) glass-ceramics, with 0 ≤ x ≤ 4 mol%, in terms of bioactivity, biocompatibility, antibacterial properties and cell viability in order to determine the most appropriate composition for their further use in in vivo trials. The sol–gel synthesized samples show a preponderantly amorphous structure with a few crystallization centers associated with the formation of an apatite and calcium carbonate crystalline phases. The Fourier Transform Infrared (FT-IR) spectra revealed slightly modified absorption bands due to the addition of copper oxide, while the information derived from the measurements performed by transmission electron microscopy, UV-vis and electron paramagnetic resonance spectroscopy showed the presence of ions and metallic copper species. X-Ray photoelectron spectroscopic analysis indicated the presence of copper metallic species, in a reduced amount, only on the sample surface with the highest Cu content. Regarding in vitro assessment of bioactivity, the results obtained by X-ray diffraction, FT-IR spectroscopy and scanning electron microscopy, demonstrated the formation of a calcium phosphate layer on all investigated sample surfaces. The inhibitory effect of the investigated samples was more significant on the Pseudomonas aeruginosa than the Staphylococcus aureus strain, the sample with the lowest concentration of copper oxide (0.5 mol%) being also the most efficient in both bacterial cultures. This sample also exhibits a very good bactericidal activity, for the other samples it was necessary to use a higher quantity to inhibit and kill the bacterial species. The secondary structure of adsorbed albumin presents few minor changes, indicating the biocompatibility of the glass-ceramics. The cell viability assay shows a good proliferation rate on samples with 0.5 and 1.5 mol% CuO, although all glass-ceramic samples exhibited a good in vivo tolerance.
Starting Page	1252
Ending Page	1265
Page Count	14
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	4
Issue Number	8
Journal	Biomaterials Science
DOI	10.1039/c6bm00270f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Copper(II) oxide Spectroscopy Viability assay Albumin Calcium phosphate Fourier-transform infrared spectroscopy Photoemission spectroscopy Scanning electron microscope Biomolecular structure Bactericide High-temperature superconductivity X-ray crystallography Glass-ceramic Transmission electron microscopy Aureus The Cell Calcium carbonate Biocompatibility Apatite Pseudomonas aeruginosa Electron paramagnetic resonance Copper
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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