NDLI: Silver-containing mesoporous bioactive glass with improved antibacterial properties

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gargiulo, Nicola Cusano, Angela Maria Causa, Filippo Caputo, Domenico Netti, Paolo Antonio
Description	Country affiliation: Italy Author Affiliation: Gargiulo N ( Centro di Ricerca Interdipartimentale sui Biomateriali, Università Federico II, P.le Tecchio 80, 80125 Naples, Italy.)
Abstract	The aim of the present work is the study of the bacteriostatic/bactericidal effect of a silver-containing mesoporous bioactive glass obtained by evaporation-induced self-assembly and successive thermal stabilization. Samples of the manufactured mesophase were characterized by means of transmission electron microscopy and $N_{2}$ adsorption/desorption at 77 K, revealing structural and textural properties similar to SBA-15 mesoporous silica. Glass samples used for bioactivity experiments were put in contact with a standardized, commercially available cell culture medium instead of lab-produced simulated body fluid, and were then characterized by means of X-ray diffraction, field emission scanning electron microscopy and Fourier transform infrared spectroscopy. All these analyses confirmed the development of a hydroxyl carbonate apatite layer on glass particles. Moreover, the investigated mesostructure showed a very good antibacterial effect against S. aureus strain, with a strong evidence of bactericidal activity already registered at 0.5 mg/mL of glass concentration. A hypothesis about the mechanism by which Ag affects the bacterial viability, based on the intermediate formation of crystalline AgCl, was also taken into account. With respect to what already reported in the literature, these findings claim a deeper insight into the possible use of silver-containing bioactive glasses as multifunctional ceramic coatings for orthopedic devices.
File Format	HTM / HTML
ISSN	09574530
Issue Number	9
Volume Number	24
e-ISSN	15734838
Journal	Journal of Materials Science: Materials in Medicine
Language	English
Publisher	Springer
Publisher Date	2013-09-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Biomedical Engineering Anti-bacterial Agents Pharmacology Biocompatible Materials Glass Silver Chemistry Microscopy, Electron, Scanning Microscopy, Electron, Transmission Spectroscopy, Fourier Transform Infrared Staphylococcus Aureus Drug Effects X-ray Diffraction Journal Article
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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