NDLI: Blending PEG-based polymers and their use in surface micro-patterning by the FIMIC method to obtain topographically smooth patterns of elasticity

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Biomaterials Science Vol - 2 Issue - 2

Biomaterials Science Vol -1

Blending PEG-based polymers and their use in surface micro-patterning by the FIMIC method to obtain topographically smooth patterns of elasticity

Content Provider	Royal Society of Chemistry (RSC)
Author	Strehmel, C. Lensen, M. C. Kelleher, S. M. Löbus, A. Zhang, Z.
Copyright Year	2014
Abstract	We have designed and fabricated a library of polyethylene glycol (PEG)-based polymer blends, including blends of two PEG-based polymers that are liquid at room temperature where the optimisation of the blending method allows for the incorporation of higher molecular-weight PEG-based polymers which are solid at room temperature. The absence of a solvent in these blends makes them perfect candidates for use in our recently developed Fill-Molding in Capillaries (FIMIC) patterning method. As our FIMIC samples have shown to be not completely smooth (a small topography up to several nanometers has been seen previously), and this is likely to affect the cellular behaviour, we have improved our technique in order to obtain virtually smooth samples that exhibit a pattern of elasticity only. It is demonstrated that, by taking advantage of the differential swelling of the pattern components, we can level out the undesired topographic difference. In particular, by employing blends of materials, (1) the swelling degree of each component can be fine-tuned to even out any topography and (2) the use of the same blends in the sample, yet with varying cross-linker amounts, ensures the swelling degree and elasticity change without changing the surface chemistry significantly. Genuine, binary patterns of elasticity can thus be fabricated, which are a great asset to study cell migration phenomena in systematic detail.
Starting Page	410
Ending Page	418
Page Count	9
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	2
Issue Number	3
Journal	Biomaterials Science
DOI	10.1039/c3bm60218d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Polyethylene glycol Capillary Polymer Surface science Library Solvent
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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