NDLI: Poly(ester-ether)s: II. Properties of electrospun nanofibres from polydioxanone and poly(methyl dioxanone) blends and human fibroblast cellular proliferation

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Poly(ester-ether)s: II. Properties of electrospun nanofibres from polydioxanone and poly(methyl dioxanone) blends and human fibroblast cellular proliferation

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Biomaterials Science Vol - 2 Issue - 2

Biomaterials Science Vol -1

Poly(ester-ether)s: II. Properties of electrospun nanofibres from polydioxanone and poly(methyl dioxanone) blends and human fibroblast cellular proliferation

Content Provider	Royal Society of Chemistry (RSC)
Author	Bhaw-Luximon, Archana Schönherr, Holger Rodriguez, Isaac A. Wesner, Daniel Bowlin, Gary L. Jhurry, Dhanjay Goonoo, Nowsheen
Copyright Year	2014
Abstract	This article deals with an in-depth study of the thermal, mechanical and degradation behaviours of nanofibres from polydioxanone (PDX) and polyDL-3-methyl-1,4-dioxan-2-one (PMeDX) and a comparison with their blend films. Varying ratios of both polymers were blended and electrospun from solution. Electrospun fibres exhibited a melting transition at 109 °C independently of the PMeDX content, which corresponds to the melting of PDX nanofibres. As a result of the drawing process, PMeDX had a reduced plasticizing effect on PDX. In general, it was observed that overall crystallinity of the fibres decreased from 53% to 36% with increasing PMeDX content and this impacted on their mechanical properties. The Young's moduli decreased as the PMeDX content of the fibres increased. However, an increase in strain at break and peak stress was noted as a result of a decrease in the fibre diameter. AFM images of the electrospun fibres showed an increasing degree of morphological heterogeneity with increasing PMeDX content. Thermal degradation studies showed that electrospun mats were thermally more stable than blend films, as confirmed by a two-fold increase in activation energy. The hydrolytic degradation of the electrospun mats conducted in phosphate buffer solution at 37 °C showed that the degradation followed a surface erosion mechanism as opposed to bulk degradation observed for blend films. Degradation of fibres was found to be mainly dependent on their diameter. On the other hand, the degradation of blend films depended on the overall crystallinity of the blends. Electrospun PDX/PMeDX nanofibrous scaffolds were also subjected to cell viability studies with human dermal fibroblasts, in which they did not show illicit response and demonstrated excellent cell attachment and proliferation.
Starting Page	339
Ending Page	351
Page Count	13
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	2
Issue Number	3
Journal	Biomaterials Science
DOI	10.1039/c3bm60211g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Thermal decomposition Phosphate Polydioxanone Buffer solution Activation energy
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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