NDLI: Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process

Content Provider	PubMed Central
Author	Martin, P. Hudspeth, A. J. Jülicher, F.
Copyright Year	2001
Abstract	Hearing relies on active filtering to achieve exquisite sensitivity and sharp frequency selectivity. In a quiet environment, the ears of many vertebrates become unstable and emit one to several tones. These spontaneous otoacoustic emissions, the most striking manifestation of the inner ear's active process, must result from self-sustained mechanical oscillations of aural constituents. The mechanoreceptive hair bundles of hair cells in the bullfrog's sacculus have the ability to amplify mechanical stimuli and oscillate spontaneously. By comparing a hair bundle's spontaneous oscillations with its response to small mechanical stimuli, we demonstrate a breakdown in a general principle of equilibrium thermodynamics, the fluctuation–dissipation theorem. We thus confirm that a hair bundle's spontaneous movements are produced by energy-consuming elements within the hair cell. To characterize the dynamical behavior of the active process, we introduce an effective temperature that, for each frequency component, quantifies a hair bundle's deviation from thermal equilibrium. The effective temperature diverges near the bundle's frequency of spontaneous oscillation. This behavior, which is not generic for active oscillators, can be accommodated by a simple model that characterizes quantitatively the fluctuations of the spontaneous movements as well as the hair bundle's linear response function.
Related Links	http://dx.doi.org/10.1073/pnas.251530598
Ending Page	14385
Page Count	6
Starting Page	14380
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	98
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2001-12-04
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process.

Compressive nonlinearity in the hair bundle's active response to mechanical stimulation

Compressive nonlinearity in the hair bundle's active response to mechanical stimulation.

Active hair-bundle movements can amplify a hair cell’s response to oscillatory mechanical stimuli

Multiple-Timescale Dynamics Underlying Spontaneous Oscillations of Saccular Hair Bundles

Control of a hair bundle's mechanosensory function by its mechanical load.

A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation

The diverse effects of mechanical loading on active hair bundles

Spontaneous voltage oscillations and response dynamics of a Hodgkin-Huxley typemodel of sensory hair cells

Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process

Similar Documents

Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process.

Compressive nonlinearity in the hair bundle's active response to mechanical stimulation

Compressive nonlinearity in the hair bundle's active response to mechanical stimulation.

Active hair-bundle movements can amplify a hair cell’s response to oscillatory mechanical stimuli

Multiple-Timescale Dynamics Underlying Spontaneous Oscillations of Saccular Hair Bundles

Control of a hair bundle's mechanosensory function by its mechanical load.

A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation

The diverse effects of mechanical loading on active hair bundles

Spontaneous voltage oscillations and response dynamics of a Hodgkin-Huxley typemodel of sensory hair cells

Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process