NDLI: A neurohistochemical blueprint for pain-induced loss of appetite

Content Provider	PubMed Central
Author	Malick, Amy Jakubowski, Moshe Elmquist, Joel K. Saper, Clifford B. Burstein, Rami
Copyright Year	2001
Abstract	A common complaint among pain patients is that they lose their appetite. These accounts are anecdotal, however, and the neural mechanism underlying pain-induced loss of appetite remains unknown. In this study, we documented the occurrence of appetite loss in patients under migraine attack and investigated the neuronal substrate of pain-induced anorexia in our animal model of intracranial pain. We found that loss of appetite during the migraine attack in humans coincided strongly with the onset and duration of the head pain in 32/39 cases, and that brief noxious stimulation of the dura in conscious rats produced a transient suppression of food intake. Mapping of neuronal activation in the rat showed that noxious dural stimulation induced a 3- to 4-fold increase in the number of Fos-positive neurons in medullary dorsal horn areas that process nociceptive signals (laminae I, V) and in parabrachial and hypothalamic neurons positioned to suppress feeding behavior. In the parabrachial area, activated neurons were localized in the superior-lateral subnucleus, and 40% of them expressed the mRNA encoding the anorectic neuropeptide cholecystokinin. In the hypothalamus, activated Fos-positive neurons were found in the dorsomedial area of the ventromedial nucleus, and 76% of them expressed the mRNA for cholecystokinin type-B receptor. Based on these findings, we suggest that at least one of several groups of hypothalamic neurons that normally inhibit appetite in response to metabolic cues is positioned to mediate the suppression of food intake by pain signals.
Related Links	http://dx.doi.org/10.1073/pnas.171616898
Ending Page	9935
Page Count	6
Starting Page	9930
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-08-14
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A neurohistochemical blueprint for pain-induced loss of appetite.

Deciphering a neuronal circuit that mediates loss of appetite

Low-back pain, lassitude and loss of appetite

The resurrection genome of Boea hygrometrica: A blueprint for survival of dehydration

Molecular structure as a blueprint for supramolecular structure chemistry in confined spaces

Blueprint for antimicrobial hit discovery targeting metabolic networks

Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness

The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity

Epidermal growth factor receptor is a preferred target for treating Amyloid-β–induced memory loss

A neurohistochemical blueprint for pain-induced loss of appetite

Similar Documents

A neurohistochemical blueprint for pain-induced loss of appetite.

Deciphering a neuronal circuit that mediates loss of appetite

Low-back pain, lassitude and loss of appetite

The resurrection genome of Boea hygrometrica: A blueprint for survival of dehydration

Molecular structure as a blueprint for supramolecular structure chemistry in confined spaces

Blueprint for antimicrobial hit discovery targeting metabolic networks

Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness

The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity

Epidermal growth factor receptor is a preferred target for treating Amyloid-β–induced memory loss

A neurohistochemical blueprint for pain-induced loss of appetite