NDLI: Brain glucose utilization in mice with a targeted mutation in the thyroid hormone α or β receptor gene

Content Provider	PubMed Central
Author	Itoh, Yoshiaki Esaki, Takanori Masahiro, Kaneshige Suzuki, Hideyo Cook, Michelle Sokoloff, Louis Cheng, Sheue-yann Nunez, Jacques
Copyright Year	2001
Abstract	Brain glucose utilization is markedly depressed in adult rats made cretinous after birth. To ascertain which subtype of thyroid hormone (TH) receptors, TRα1 or TRβ, is involved in the regulation of glucose utilization during brain development, we used the 2-[14C]deoxyglucose method in mice with a mutation in either their TRα or TRβ gene. A C insertion produced a frameshift mutation in their carboxyl terminus. These mutants lacked TH binding and transactivation activities and exhibited potent dominant negative activity. Glucose utilization in the homozygous TRβPV mutant mice and their wild-type siblings was almost identical in 19 brain regions, whereas it was markedly reduced in all brain regions of the heterozygous TRα1PV mice. These suggest that the α1 receptor mediates the TH effects in brain. Inasmuch as local cerebral glucose utilization is closely related to local synaptic activity, we also examined which thyroid hormone receptor is involved in the expression of synaptotagmin-related gene 1 (Srg1), a TH-positively regulated gene involved in the formation and function of synapses [Thompson, C. C. (1996) J. Neurosci. 16, 7832–7840]. Northern analysis showed that Srg1 expression was markedly reduced in the cerebellum of TRα PV/+ mice but not TRβ PV/PV mice. These results show that the same receptor, TRα1, is involved in the regulation by TH of both glucose utilization and Srg1 expression.
Related Links	http://dx.doi.org/10.1073/pnas.171319498
Ending Page	9918
Page Count	6
Starting Page	9913
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-08-14
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mice with a targeted mutation in the thyroid hormone β receptor gene exhibit impaired growth and resistance to thyroid hormone

Brain glucose utilization in mice with a targeted mutation in the thyroid hormone alpha or beta receptor gene.

Liver X receptor β and thyroid hormone receptor α in brain cortical layering

Contrasting Skeletal Phenotypes in Mice with an Identical Mutation Targeted to Thyroid Hormone Receptor α1 or β

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor α

Role of TSH in the Spontaneous Development of Asymmetrical Thyroid Carcinoma in Mice with a Targeted Mutation in a Single Allele of the Thyroid Hormone-β Receptor

A targeted dominant negative mutation of the thyroid hormone α1 receptor causes increased mortality, infertility, and dwarfism in mice

A thyroid hormone receptor mutation that dissociates thyroid hormone regulation of gene expression in vivo

Role of TSH in the Spontaneous Development of Asymmetrical Thyroid Carcinoma in Mice with a Targeted Mutation in a Single Allele of the Thyroid Hormone-β Receptor

Brain glucose utilization in mice with a targeted mutation in the thyroid hormone α or β receptor gene

Similar Documents

Mice with a targeted mutation in the thyroid hormone β receptor gene exhibit impaired growth and resistance to thyroid hormone

Brain glucose utilization in mice with a targeted mutation in the thyroid hormone alpha or beta receptor gene.

Liver X receptor β and thyroid hormone receptor α in brain cortical layering

Contrasting Skeletal Phenotypes in Mice with an Identical Mutation Targeted to Thyroid Hormone Receptor α1 or β

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor α

Role of TSH in the Spontaneous Development of Asymmetrical Thyroid Carcinoma in Mice with a Targeted Mutation in a Single Allele of the Thyroid Hormone-β Receptor

A targeted dominant negative mutation of the thyroid hormone α1 receptor causes increased mortality, infertility, and dwarfism in mice

A thyroid hormone receptor mutation that dissociates thyroid hormone regulation of gene expression in vivo

Role of TSH in the Spontaneous Development of Asymmetrical Thyroid Carcinoma in Mice with a Targeted Mutation in a Single Allele of the Thyroid Hormone-β Receptor

Brain glucose utilization in mice with a targeted mutation in the thyroid hormone α or β receptor gene