NDLI: Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins.

Please wait, while we are loading the content...

Year: 2016, Volume: 113

Year: 2015, Volume: 112

Year: 2014, Volume: 111

Year: 2013, Volume: 110

Year: 2012, Volume: 109

Year: 2011, Volume: 109

Year: 2011, Volume: 108

Year: 2010, Volume: 107

Year: 2009, Volume: 106

Year: 2009, Volume: 94

Year: 2008, Volume: 105

Year: 2007, Volume: 104

Year: 2006, Volume: 103

Year: 2005, Volume: 103

Year: 2005, Volume: 102

Year: 2004, Volume: 101

Year: 2003, Volume: 100

Year: 2002, Volume: 99

Year: 2001, Volume: 98

Year: 2000, Volume: 97

Year: 1999, Volume: 96

Year: 1998, Volume: 95

Year: 1997, Volume: 94

Year: 1996, Volume: 93

Year: 1995, Volume: 92

Year: 1994, Volume: 91

Year: 1993, Volume: 90

Year: 1992, Volume: 89

Year: 1991, Volume: 88

Year: 1991, Volume: 88, Issue: 24

Year: 1991, Volume: 88, Issue: 23

Year: 1991, Volume: 88, Issue: 22

Year: 1991, Volume: 88, Issue: 21

Year: 1991, Volume: 88, Issue: 20

Year: 1991, Volume: 88, Issue: 19

Year: 1991, Volume: 88, Issue: 18

Year: 1991, Volume: 88, Issue: 17

Year: 1991, Volume: 88, Issue: 16

Year: 1991, Volume: 88, Issue: 15

Year: 1991, Volume: 88, Issue: 14

Year: 1991, Volume: 88, Issue: 13

Year: 1991, Volume: 88, Issue: 12

Year: 1991, Volume: 88, Issue: 11

Year: 1991, Volume: 88, Issue: 10

Year: 1991, Volume: 88, Issue: 9

Year: 1991, Volume: 88, Issue: 8

Sequential truncation of the lactose permease over a three-amino acid sequence near the carboxyl terminus leads to progressive loss of activity and stability.

Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.

A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation.

Stable three-stranded DNA made by RecA protein.

Crystal structure of the neutral form of fructose-1,6-bisphosphatase complexed with the product fructose 6-phosphate at 2.1-A resolution.

Structurally intact (78-kDa) forms of maternal lactoferrin purified from urine of preterm infants fed human milk: identification of a trypsin-like proteolytic cleavage event in vivo that does not result in fragment dissociation.

Early ingrowth of thalamocortical afferents to the neocortex of the prenatal rat.

Structure and promoter activity of the gene for the erythroid transcription factor GATA-1.

Identification of an evolutionarily conserved, function-associated molecule on human natural killer cells.

Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture.

Intracellular sites for storage and recycling of C3b receptors in human neutrophils.

Differential effect of cysteine-to-serine substitutions in metallothionein on cadmium resistance.

Replication deficiencies in priA mutants of Escherichia coli lacking the primosomal replication n' protein.

Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering.

Polyadenylylation in copia requires unusually distant upstream sequences.

Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments.

Selective abstraction of 2H from C-5' of thymidylate in an oligodeoxynucleotide by the radical center at C-6 of the diradical species of neocarzinostatin: chemical evidence for the structure of the activated drug-DNA complex.

Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility gene.

Metalloselenonein, the selenium analogue of metallothionein: synthesis and characterization of its complex with copper ions.

An idiotypic network model of AIDS immunopathogenesis.

Many peptide fragments of alien antigens are homologous with host proteins, thus canalizing T-cell responses.

Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies.

Helical repeat and chirality effects on DNA gel electrophoretic mobility.

The role of the retinylidene Schiff base counterion in rhodopsin in determining wavelength absorbance and Schiff base pKa.

Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting.

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

Detection of human immunodeficiency virus type 1 clinical isolates with reduced sensitivity to zidovudine and dideoxyinosine by RNA.RNA hybridization.

Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes.

Localization of the estrogen-binding site of alpha-fetoprotein in the chimeric human-rat proteins.

Expression of a soluble and functional form of the human beta 2 integrin CD11b/CD18.

Site-specific integration of mycobacteriophage L5: integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette-Guérin.

The amino acid sequence of a glutamic acid-rich protein from bovine retina as deduced from the cDNA sequence.

The arflike gene encodes an essential GTP-binding protein in Drosophila.

Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.

Thyrotropin-releasing hormone regulation of human TSHB expression: role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thyroid hormone-inhibitory element.

Transcription mediated by a cAMP-responsive promoter element is reduced upon activation of dopamine D2 receptors.

Plasmodium falciparum appears to have arisen as a result of lateral transfer between avian and human hosts.

Negative regulation of the major histocompatibility complex class I promoter in embryonal carcinoma cells.

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

Lymphocytes as cellular vehicles for gene therapy in mouse and man.

The molecular genetic basis of Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations in Israel.

Inositol 1,3,4,5-tetrakisphosphate and inositol hexakisphosphate receptor proteins: isolation and characterization from rat brain.

Characterization of a dopamine receptor (DA2K) in the kidney inner medulla.

Sequestrin, a CD36 recognition protein on Plasmodium falciparum malaria-infected erythrocytes identified by anti-idiotype antibodies.

Identification of two forms of the RNA polymerase I transcription factor UBF.

Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor.

Assembly and analysis of a functional vaccinia virus "amplicon" containing the C-repeat region from the M protein of Streptococcus pyogenes.

Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.

Cytokine regulation of substance P expression in sympathetic neurons.

The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops.

Vanadate-resistant yeast mutants are defective in protein glycosylation.

Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity.

Transplantation of wheat germ agglutinin-positive hematopoietic cells to prevent or induce systemic autoimmune disease.

Bayesian image reconstruction for emission tomography incorporating Good's roughness prior on massively parallel processors.

Complete separation of intracellular and extracellular information in NMR spectra of perfused cells by diffusion-weighted spectroscopy.

Construction, arraying, and high-density screening of large insert libraries of human chromosomes X and 21: their potential use as reference libraries.

Production of site-selected neutralizing human monoclonal antibodies against the third variable domain of the human immunodeficiency virus type 1 envelope glycoprotein.

Tissue distribution of the dystrophin-related gene product and expression in the mdx and dy mouse.

Sequence of a cysteine-rich galactose-specific lectin of Entamoeba histolytica.

Complementation between Sindbis viral RNAs produces infectious particles with a bipartite genome.

Purification and characterization of an alpha-bungarotoxin receptor that forms a functional nicotinic channel.

Solution of the coupled Einstein-Maxwell equations in oblate spheroidal coordinates.

Equilibrium compositions of solutions of biochemical species and heats of biochemical reactions.

Resolution of component proteins in an enzyme complex from Methanosarcina thermophila catalyzing the synthesis or cleavage of acetyl-CoA.

Enzymatic basis for hydrolytic versus phosphorolytic mRNA degradation in Escherichia coli and Bacillus subtilis.

Product of the Pseudomonas aeruginosa gene pilD is a prepilin leader peptidase.

Patterns of gene expression that characterize the colonic mucosa in patients at genetic risk for colonic cancer.

Class II-restricted presentation of an endogenously derived immunodominant T-cell determinant of hen egg lysozyme.

Retrotransposable elements R1 and R2 interrupt the rRNA genes of most insects.

Human cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein.

Use of heteropolymeric monoclonal antibodies to attach antigens to the C3b receptor of human erythrocytes: a potential therapeutic treatment.

Feedforward lateral inhibition in retinal bipolar cells: input-output relation of the horizontal cell-depolarizing bipolar cell synapse.

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

Oligopyrimidine tract at the 5' end of mammalian ribosomal protein mRNAs is required for their translational control.

Modification of the coding sequence enhances plant expression of insect control protein genes.

Preparation, properties, and plasma retention of human hemoglobin derivatives: comparison of uncrosslinked carboxymethylated hemoglobin with crosslinked tetrameric hemoglobin.

Tc4, a Caenorhabditis elegans transposable element with an unusual fold-back structure.

Interleukin 4 promotes expression of mast cell ICAM-1 antigen.

Autoantigenicity of Ro/SSA antigen is related to a nucleocapsid protein of vesicular stomatitis virus.

Observations after human immunodeficiency virus immunization and challenge of human immunodeficiency virus seropositive and seronegative chimpanzees.

Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin.

Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease.

RecBCD-dependent joint molecule formation promoted by the Escherichia coli RecA and SSB proteins.

Acidic and basic fibroblast growth factors are survival factors with distinctive activity in quiescent BALB/c 3T3 murine fibroblasts.

Isolation and characterization of cDNA clones encoding a functional p34cdc2 homologue from Zea mays.

Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7.

A transition metal complex (Venus flytrap cluster) for radioimmunodetection and radioimmunotherapy.

Nucleotide sequence and mutation rate of the H strain of hepatitis C virus.

Identification and characterization of cellular binding proteins (receptors) for recombinant human bone morphogenetic protein 2B, an initiator of bone differentiation cascade.

Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice.

Rational design of receptor-specific variants of human growth hormone.

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.

Evidence for coordinate regulation of the A system for amino acid transport and the mRNA for the alpha 1 subunit of the Na+,K(+)-ATPase gene in Chinese hamster ovary cells.

Human response against NP-4, a mouse antibody to carcinoembryonic antigen: human anti-idiotype antibodies mimic an epitope on the tumor antigen.

Early visual deprivation results in a degraded motor map in the optic tectum of barn owls.

Characterization of tissue-specific transcription by the human synapsin I gene promoter.

Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking.

Three-dimensional structure of human basic fibroblast growth factor.

Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta.

Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration.

A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases.

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

Exonucleolytic proofreading of leading and lagging strand DNA replication errors.

High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.

Genetic linkage of autosomal recessive canine narcolepsy with a mu immunoglobulin heavy-chain switch-like segment.

Secondary structure of the phosphocarrier protein IIIGlc, a signal-transducing protein from Escherichia coli, determined by heteronuclear three-dimensional NMR spectroscopy.

BHK cell lines with increased rates of gene amplification are hypersensitive to ultraviolet light.

Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins.

Global and local metric geometry of ligand binding thermodynamics.

Generation of sensory neurons is stimulated by leukemia inhibitory factor.

Inactivation of maize transposon Mu suppresses a mutant phenotype by activating an outward-reading promoter near the end of Mu1.

Self-similarity of the "1/f noise" called music.

In vitro neurons in mammalian cortical layer 4 exhibit intrinsic oscillatory activity in the 10-to 50-Hz frequency range

Cardiac fibroblasts are predisposed to convert into myocyte phenotype: Specific effect of transforming growth factor β

Physiological induction and reversal of focus formation and tumorigenicity in NIH 3T3 cells

Year: 1991, Volume: 88, Issue: 7

Year: 1991, Volume: 88, Issue: 6

Year: 1991, Volume: 88, Issue: 5

Year: 1991, Volume: 88, Issue: 4

Year: 1991, Volume: 88, Issue: 3

Year: 1991, Volume: 88, Issue: 2

Year: 1991, Volume: 88, Issue: 1

Year: 1990, Volume: 87

Year: 1989, Volume: 86

Year: 1988, Volume: 85

Year: 1987, Volume: 84

Year: 1986, Volume: 83

Year: 1985, Volume: 82

Year: 1984, Volume: 81

Year: 1983, Volume: 80

Year: 1982, Volume: 79

Year: 1981, Volume: 78

Year: 1980, Volume: 77

Year: 1979, Volume: 76

Year: 1978, Volume: 75

Year: 1977, Volume: 74

Year: 1976, Volume: 73

Year: 1975, Volume: 72

Year: 1974, Volume: 71

Year: 1973, Volume: 70

Year: 1972, Volume: 69

Year: 1971, Volume: 68

Year: 1970, Volume: 67

Year: 1970, Volume: 66

Year: 1970, Volume: 65

Year: 1969, Volume: 64

Year: 1969, Volume: 63

Year: 1969, Volume: 62

Year: 1968, Volume: 61

Year: 1968, Volume: 60

Year: 1968, Volume: 59

Year: 1967, Volume: 58

Year: 1967, Volume: 57

Year: 1966, Volume: 56

Year: 1966, Volume: 55

Year: 1965, Volume: 54

Year: 1965, Volume: 53

Year: 1964, Volume: 52

Year: 1964, Volume: 51

Year: 1963, Volume: 50

Year: 1963, Volume: 49

Year: 1962, Volume: 48

Year: 1961, Volume: 47

Year: 1960, Volume: 46

Year: 1959, Volume: 45

Year: 1958, Volume: 44

Year: 1957, Volume: 43

Year: 1956, Volume: 42

Year: 1955, Volume: 41

Year: 1954, Volume: 40

Year: 1953, Volume: 39

Year: 1952, Volume: 38

Year: 1951, Volume: 37

Year: 1950, Volume: 36

Year: 1949, Volume: 35

Year: 1948, Volume: 34

Year: 1947, Volume: 33

Year: 1946, Volume: 32

Year: 1945, Volume: 31

Year: 1944, Volume: 30

Year: 1943, Volume: 29

Year: 1942, Volume: 28

Year: 1941, Volume: 27

Year: 1940, Volume: 26

Year: 1939, Volume: 25

Year: 1938, Volume: 24

Year: 1937, Volume: 23

Year: 1936, Volume: 22

Year: 1935, Volume: 21

Year: 1934, Volume: 20

Year: 1933, Volume: 19

Year: 1932, Volume: 18

Year: 1931, Volume: 17

Year: 1930, Volume: 16

Year: 1929, Volume: 15

Year: 1928, Volume: 14

Year: 1927, Volume: 13

Year: 1926, Volume: 12

Year: 1925, Volume: 11

Year: 1924, Volume: 10

Year: 1923, Volume: 9

Year: 1922, Volume: 8

Year: 1921, Volume: 7

Year: 1920, Volume: 6

Year: 1919, Volume: 5

Year: 1918, Volume: 4

Year: 1917, Volume: 3

Year: 1916, Volume: 2

Year: 1915, Volume: 1

Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins.

Content Provider	PubMed Central
Author	Missero, C. Filvaroff, E. Dotto, G. P.
Abstract	Transforming growth factors beta (TGF-beta s) are potent inhibitors of epithelial cell growth in culture and might play a similar role in vivo. Several studies have suggested that acquisition of TGF-beta resistance is an important step in epithelial tumor development. Here, we show that resistance to TGF-beta 1 growth inhibition can be induced by transformation of keratinocytes with the E1A, but not the ras, oncogene. Mutational analysis revealed that these effects closely correlate with the ability of E1A proteins to bind to the retinoblastoma gene product (p105) as well as to three other cellular proteins (p60, p107, and p300). Only partial resistance to TGF-beta 1 growth inhibition was elicited by E1A mutants that bind to a subset of proteins, whereas complete resistance was induced by E1A mutants that bind to all four proteins together. Total protection against TGF-beta growth inhibition was also induced by concomitant introduction into cells of an E1A mutant binding to the p60/p105/p107 proteins and one binding to p300. In parallel with these effects, epidermal transglutaminase, a marker of keratinocyte differentiation, was induced by TGF-beta in control but not in E1A-transformed cells. TGF-beta 1 receptor levels were only partially down-modulated by an intact E1A gene and not significantly affected by the various truncated mutants. Thus, the ability of E1A to induce TGF-beta resistance depends on its ability to bind, and presumably inactivate, several cellular proteins that may be involved in transmission of the TGF-beta signal and seem to act downstream from its receptor(s).
Starting Page	3489
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	88
Language	English
Publisher Date	1991-04-15
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in