NDLI: Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for Arabidopsis flower development

Content Provider	PubMed Central
Author	Sridhar, Vaniyambadi V. Surendrarao, Anandkumar Gonzalez, Deyarina Conlan, R. Steven Liu, Zhongchi
Copyright Year	2004
Abstract	Transcription repression plays important roles in preventing crucial regulatory proteins from being expressed in inappropriate temporal or spatial domains. LEUNIG (LUG) and SEUSS (SEU) normally act to prevent ectopic expression of the floral homeotic gene AGAMOUS in flowers. LUG encodes a protein with sequence similarities to the yeast Tup1 corepressor. SEU encodes a plant-specific regulatory protein with sequence similarity in a conserved dimerization domain to the LIM-domain binding 1/Chip proteins in mouse and Drosophila. Despite the molecular isolation of LUG and SEU, the biochemical function of these two proteins remains uncharacterized, and the mechanism of AGAMOUS repression remains unknown. Here, we report that LUG and SEU interact directly in vitro and in vivo. Furthermore, LUG exhibits a strong repressor activity on several heterologous promoters in yeast and plant cells. SEU, in contrast, does not exhibit any direct repressor activity, but can repress reporter gene expression only in the presence of LUG, indicating a possible role of SEU as an adaptor protein for LUG. Our results demonstrate that LUG encodes a functional homologue of Tup1 and that SEU may function similarly to Ssn6, an adaptor protein of Tup1. We have defined the LUG/LUH, Flo8, single-strand DNA-binding protein domain of LUG as both necessary and sufficient for the interaction with SEU and two domains of LUG as important for its repressor function. Our work provides functional insights into plant transcriptional corepressors and reveals both conservation and distinctions between plant corepressors and those of yeast and animals.
Related Links	http://dx.doi.org/10.1073/pnas.0403055101
Ending Page	11499
Page Count	6
Starting Page	11494
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	31
Volume Number	101
Language	English
Publisher	National Academy of Sciences
Publisher Date	2004-08-03
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for Arabidopsis flower development.

LEUNIG, a putative transcriptional corepressor that regulates AGAMOUS expression during flower development

SEUSS, a member of a novel family of plant regulatory proteins, represses floral homeotic gene expression with LEUNIG

Repression of stress-responsive genes by FIERY2, a novel transcriptional regulator in Arabidopsis

APETALA1 and SEPALLATA3 interact with SEUSS to mediate transcription repression during flower development

SEUSS and LEUNIG regulate cell proliferation, vascular development and organ polarity in Arabidopsis petals

Two regulatory levels of transcriptional gene silencing in Arabidopsis

Genetic Control by Arabidopsis Genes LEUNIG and FILAMENTOUS FLOWER in Gynoecium Fusion

LEUNIG and SEUSS co-repressors regulate miR172 expression in Arabidopsis flowers

Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for Arabidopsis flower development

Similar Documents

Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for Arabidopsis flower development.

LEUNIG, a putative transcriptional corepressor that regulates AGAMOUS expression during flower development

SEUSS, a member of a novel family of plant regulatory proteins, represses floral homeotic gene expression with LEUNIG

Repression of stress-responsive genes by FIERY2, a novel transcriptional regulator in Arabidopsis

APETALA1 and SEPALLATA3 interact with SEUSS to mediate transcription repression during flower development

SEUSS and LEUNIG regulate cell proliferation, vascular development and organ polarity in Arabidopsis petals

Two regulatory levels of transcriptional gene silencing in Arabidopsis

Genetic Control by Arabidopsis Genes LEUNIG and FILAMENTOUS FLOWER in Gynoecium Fusion

LEUNIG and SEUSS co-repressors regulate miR172 expression in Arabidopsis flowers

Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for Arabidopsis flower development