NDLI: Subfertility and defective folliculogenesis in female mice lacking androgen receptor

Content Provider	PubMed Central
Author	Hu, Yueh-chiang Wang, Peng-hui Yeh, Shuyuan Wang, Ruey-sheng Xie, Chao Xu, Qingquan Zhou, Xinchang Chao, Hsiang-tai Tsai, Meng-yin Chang, Chawnshang
Copyright Year	2004
Abstract	The roles of the androgen receptor (AR) in female fertility and ovarian function remain largely unknown. Here we report on the generation of female mice lacking AR (AR –/–) and the resulting influences on the reproductive system. Female AR –/– mice appear normal but show longer estrous cycles and reduced fertility. The ovaries from sexually mature AR –/– females exhibited a marked reduction in the number of corpora lutea. After superovulation treatment, the AR –/– ovaries produced fewer oocytes and also showed fewer corpora lutea. During the periovulatory period, an intensive granulosa apoptosis event occurs in the AR –/– preovulatory follicles, concurrent with the down-regulation of p21 and progesterone receptor expression. Furthermore, the defective conformation of the cumulus cell–oocyte complex from the AR –/– females implies a lower fertilization capability of the AR –/– oocytes. In addition to insufficient progesterone production, the diminished endometrial growth in uteri in response to exogenous gonadotropins indicates that AR –/– females exhibit a luteal phase defect. Taken together, these data provide in vivo evidence showing that AR plays an important role in female reproduction.
Related Links	http://dx.doi.org/10.1073/pnas.0404372101
Ending Page	11214
Page Count	6
Starting Page	11209
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	31
Volume Number	101
Language	English
Publisher	National Academy of Sciences
Publisher Date	2004-08-03
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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