NDLI: Association between pre-miR-27a functional polymorphism and risk of colorectal cancer in north Chinese Han population

Content Provider	PubMed Central
Author	Bian, Quan Chen, Jian-jun Gu, Jun-ping Xu, Jing
Copyright Year	2015
Abstract	MicroRNA-27a (miR-27a) is deemed as an oncogene in malignancies including colorectal cancer (CRC), and rs895819 within pre-miR-27a may affect its secondary structure, leading to its aberrant expression and dysfunction of its targeted gene. We investigated genotype and allele frequencies of the locus in 412 I–III stage CRC cases and 412 age- and sex-matched healthy individuals to explore the possible association between them in the north of Chinese population. The results showed that frequencies of alleles A and G and genotypes GG, AG, and AA of the locus were 65.7%, 34.3%, 17.0%, 34.7%, and 48.3% in cases and 69.9%, 30.1%, 9.9%, 40.2%, and 49.8% in controls, respectively. GG genotype of the locus was positively associated with an increased risk of CRC in codominant (P=0.01, adjusted odds ratio =1.541, 95% confidence interval =1.110–2.239 for genotype GG vs AA) and recessive (P=0.003, adjusted odds ratio =1.855, 95% confidence interval =1.221–2.786 for genotype GG vs AA/GA) models, indicating that GG genotype of the locus might increase susceptibility to CRC. Moreover, genotypes AG and GG and allele G were significantly associated with III stage (P<0.001, P<0.001, and P=0.001, respectively), suggesting that the locus was associated with the progression of CRC. These results suggested that rs895819 within pre-miR-27a was involved in colorectal carcinogenesis and progression, genotype GG of the locus might be a susceptible factor for CRC, and allele G and allele G carrier (genotypes AG and GG) could predict CRC progression in north Chinese Han population.
Related Links	http://dx.doi.org/10.2147/ott.s89754
Ending Page	3007
Starting Page	3003
File Format	PDF
ISSN	11786930
e-ISSN	11786930
Journal	OncoTargets and therapy
Volume Number	8
Language	English
Publisher	Dove Medical Press
Publisher Date	2015-10-01
Access Restriction	Open
Rights Holder	Dove Medical Press
Subject Keyword	Pharmacology (medical) Oncology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Oncology

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