NDLI: HES1 is an independent prognostic factor for acute myeloid leukemia

Content Provider	PubMed Central
Author	Tian, Chen Tang, Yingjun Wang, Tengteng Yu, Yong Wang, Xiaofang Wang, Yafei Zhang, Yizhuo
Copyright Year	2015
Abstract	HES1 is the target of Notch signaling which is reported to affect cell differentiation and maintain the cells in G0 phase in various tissues including the hematopoietic tissue. HES1 expression appears to be an independent prognostic factor for survival in a heterogeneous group of acute myeloid leukemia (AML) patients. To better assess its significance, we analyzed HES1 expression in a group of non-core binding factor AML patients and correlated its expression with the overall survival and relapse-free survival of AML patients. First, we detected the messenger RNA expression of HES1 in 40 patients with AML by real-time polymerase chain reaction. The top 50% of AML cases with the high HES1 expression were compared with the rest of the AML cohort. Overall survival was calculated from the date of diagnosis until the date of death from any cause or until the date of final follow-up. Relapse-free survival was determined for responders from the time of diagnosis until relapse or death from any cause. We showed that the lower-expression group had a shorter overall survival time and shorter relapse-free survival time compared with those of the high-expression group (37.6±1.6 versus 54.0±1.3 months, 28.6±1.8 months versus 44.8±2.1 months, respectively, P<0.05), and Cox regression showed that HES1 was an independent prognostic factor. In all, we conclude that expression of HES1 is a useful prognostic factor for patients with non-core binding factor AML.
Related Links	http://dx.doi.org/10.2147/ott.s83511
Ending Page	904
Starting Page	899
File Format	PDF
ISSN	11786930
e-ISSN	11786930
Journal	OncoTargets and therapy
Volume Number	8
Language	English
Publisher	Dove Medical Press
Publisher Date	2015-04-01
Access Restriction	Open
Rights Holder	Dove Medical Press
Subject Keyword	Pharmacology (medical) Oncology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

HES1 is an independent prognostic factor for acute myeloid leukemia

Loss of TRIM62 Expression Is an Independent Adverse Prognostic Factor in Acute Myeloid Leukemia

Highly Phosphorylated FOXO3A Is an Adverse Prognostic Factor in Acute Myeloid Leukemia

The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia

CEBPE expression is an independent prognostic factor for acute myeloid leukemia

High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions

Loss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemia.

The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia

GPX3 hypermethylation serves as an independent prognostic biomarker in non-M3 acute myeloid leukemia

HES1 is an independent prognostic factor for acute myeloid leukemia

Similar Documents

HES1 is an independent prognostic factor for acute myeloid leukemia

Loss of TRIM62 Expression Is an Independent Adverse Prognostic Factor in Acute Myeloid Leukemia

Highly Phosphorylated FOXO3A Is an Adverse Prognostic Factor in Acute Myeloid Leukemia

The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia

CEBPE expression is an independent prognostic factor for acute myeloid leukemia

High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions

Loss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemia.

The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia

GPX3 hypermethylation serves as an independent prognostic biomarker in non-M3 acute myeloid leukemia

HES1 is an independent prognostic factor for acute myeloid leukemia