NDLI: Combination of icotinib, surgery, and internal-radiotherapy of a patient with lung cancer severely metastasized to the vertebrae bones with EGFR mutation: a case report

Content Provider	PubMed Central
Author	Qu, Li-li Qin, Hai-feng Gao, Hong-jun Liu, Xiao-qing
Copyright Year	2015
Abstract	A 48-year-old Chinese female was referred to us regarding EGFR-mutated advanced non-small cell lung cancer, and metastasis to left scapula and vertebrae bones which caused pathological fracture at T8 and T10 thoracic vertebrae. An aggressive combined therapy with icotinib, vertebrae operation, and radioactive particle implantation and immunotherapy was proposed to prevent paraplegia, relieve pain, and control the overall and local tumor lesions. No postoperative symptoms were seen after surgery, and the pain was significantly relieved. Icotinib merited a 31-month partial response with grade 1 diarrhea as its drug-related adverse event. High dose of icotinib was administered after pelvis lesion progression for 3 months with good tolerance. Combination therapy of icotinib, surgery, and internal radiation for metastases of the vertebrae bones from non-small cell lung cancer seems to be a very promising technique both for sufficient pain relief and for local control of the tumor, vertebrae operation can be an encouraging option for patients with EFGR positive mutation and good prognosis indicator.
Related Links	http://dx.doi.org/10.2147/ott.s80012
Ending Page	1276
Starting Page	1271
File Format	PDF
ISSN	11786930
e-ISSN	11786930
Journal	OncoTargets and therapy
Volume Number	8
Language	English
Publisher	Dove Medical Press
Publisher Date	2015-06-01
Access Restriction	Open
Rights Holder	Dove Medical Press
Subject Keyword	Pharmacology (medical) Oncology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Oncology

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Combination of icotinib, surgery, and internal-radiotherapy of a patient with lung cancer severely metastasized to the vertebrae bones with EGFR mutation: a case report

Combination of icotinib, surgery, and internal-radiotherapy of a patient with lung cancer severely metastasized to the vertebrae bones with EGFR mutation: a case report

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Combination of icotinib, surgery, and internal-radiotherapy of a patient with lung cancer severely metastasized to the vertebrae bones with EGFR mutation: a case report

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