NDLI: Farnesoid X Receptor Inhibits Glucagon-Like Peptide-1 Production by Enteroendocrine L-cells

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Year: 2016, Volume: 7

Year: 2015, Volume: 6

Year: 2015, Volume: 6, Issue: Unspecified

Flexible and self-powered temperature–pressure dual-parameter sensors using microstructure-frame-supported organic thermoelectric materials

Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naïve-to-memory B-cell transition

IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells

A fungal protease allergen provokes airway hyperresponsiveness in asthma

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

Asymmetric intramolecular α-cyclopropanation of aldehydes using a donor/acceptor carbene mimetic

Synthesis of three-dimensionally interconnected sulfur-rich polymers for cathode materials of high-rate lithium–sulfur batteries

Genetic targeting of sprouting angiogenesis using Apln-CreER

Chemical reaction mechanisms in solution from brute force computational Arrhenius plots

Consequences of chirality on the dynamics of a water-soluble supramolecular polymer

Allelic variation contributes to bacterial host specificity

Efficiently photo-charging lithium-ion battery by perovskite solar cell

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair

Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice

Highly active oxygen reduction non-platinum group metal electrocatalyst without direct metal–nitrogen coordination

A single cyclin–CDK complex is sufficient for both mitotic and meiotic progression in fission yeast

Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A

Simultaneous enhancements in photon absorption and charge transport of bismuth vanadate photoanodes for solar water splitting

Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer

Unlocking the energy capabilities of micron-sized LiFePO4

Ligand regulation of a constitutively dimeric EGF receptor

A tunable artificial circadian clock in clock-defective mice

Earliest modern human-like hand bone from a new >1.84-million-year-old site at Olduvai in Tanzania

Dynamical backaction cooling with free electrons

Nonradiating anapole modes in dielectric nanoparticles

Uniaxial stress control of skyrmion phase

Stable ultrathin partially oxidized copper film electrode for highly efficient flexible solar cells

Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

A highly selective biosynthetic pathway to non-natural C50 carotenoids assembled from moderately selective enzymes

Cyclic diguanylate monophosphate directly binds to human siderocalin and inhibits its antibacterial activity

APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma

Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission

The ZNF304-integrin axis protects against anoikis

Investigating Alfvénic wave propagation in coronal open-field regions

Tandem C–H oxidation/cyclization/rearrangement and its application to asymmetric syntheses of (−)-brussonol and (−)-przewalskine E

Intracellular CD24 disrupts the ARF–NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation

Plastid establishment did not require a chlamydial partner

SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation

Observation of universal strong orbital-dependent correlation effects in iron chalcogenides

A magneto-electro-optical effect in a plasmonic nanowire material

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Eco-evolutionary feedbacks during experimental range expansions

Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos

Meta-analysis identifies seven susceptibility loci involved in the atopic march

Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis

Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family

Large increases in carbon burial in northern lakes during the Anthropocene

PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence

RCAN1 links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in Down syndrome

Corrigendum: Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival

Reconstructing the transport history of pebbles on Mars

Characterization of genome-wide ordered sequence-tagged Mycobacterium mutant libraries by Cartesian Pooling-Coordinate Sequencing

Systematic pan-cancer analysis of tumour purity

Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture

Corrigendum: Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals

Maternal bile acid transporter deficiency promotes neonatal demise

Ribozyme-enhanced single-stranded Ago2-processed interfering RNA triggers efficient gene silencing with fewer off-target effects

Increased tolerance to humans among disturbed wildlife

A Weyl Fermion semimetal with surface Fermi arcs in the transition metal monopnictide TaAs class

Dislocation-mediated relaxation in nanograined columnar palladium films revealed by on-chip time-resolved HRTEM testing

Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection

Early emergence of Yersinia pestis as a severe respiratory pathogen

A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families

Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes

Tonic endocannabinoid-mediated modulation of GABA release is independent of theCB1 content of axon terminals

Time reversal and charge conjugation in an embedding quantum simulator

An iron-based green approach to 1-h production of single-layer graphene oxide

The circadian clock rephases during lateral root organ initiation in Arabidopsis thaliana

Baleen whales host a unique gut microbiome with similarities to both carnivores and herbivores

The jasmonate-responsive GTR1 transporter is required for gibberellin-mediated stamen development in Arabidopsis

The immunomodulating V and W proteins of Nipah virus determine disease course

Giant barocaloric effects at low pressure in ferrielectric ammonium sulphate

Honokiol blocks and reverses cardiac hypertrophy in mice byactivating mitochondrial SIRT3

Origin of band gaps in graphene on hexagonal boron nitride

Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

Genetic discovery for oil production and quality in sesame

Kumada–Grignard-type biaryl couplings on water

Misfit accommodation mechanism at the heterointerface between diamond and cubic boron nitride

Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome

IRF8 directs stress induced autophagy in macrophages and promotes clearance of Listeria monocytogenes

A Short N-terminal Domain of HDAC4 Preserves Photoreceptors and Restores Visual Function in Retinitis Pigmentosa

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

An analytical framework for optimizing variant discovery from personal genomes

Structural analysis of hierarchically organized zeolites

Intrinsically stretchable and transparent thin-film transistors based on printable silver nanowires, carbon nanotubes and an elastomeric dielectric

Design of aqueous redox-enhanced electrochemical capacitors with high specific energies and slow self-discharge

Direct exfoliation and dispersion of two-dimensional materials in pure water via temperature control

Cell populations can use aneuploidy to survive telomerase insufficiency

Ultra-low-frequency wave-driven diffusion of radiation belt relativistic electrons

Shared genetic aetiology of puberty timing between sexes and with health-related outcomes

Generation and Expansion of highly-pure Motor Neuron Progenitors from Human Pluripotent Stem Cells

Borromean three-body FRET in frozen Rydberg gases

Direct observation of TALE protein dynamics reveals a two-state search mechanism

A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females

Structure and gating of the nuclear pore complex

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA

Identification of Alp1U and Lom6 as epoxy hydrolases and implications for kinamycin and lomaiviticin biosynthesis

The Lingula genome provides insights into brachiopod evolution and the origin of phosphate biomineralization

Suppressing molecular motions for enhanced room-temperature phosphorescence of metal-free organic materials

Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis

Ant groups optimally amplify the effect of transiently informed individuals

Mitotic redistribution of the mitochondrial network by Miro and Cenp-F

Zeolite-like liquid crystals

Transient signal generation in a self-assembled nanosystem fueled by ATP

Visualization of molecular fluorescence point spread functions via remote excitation switching fluorescence microscopy

Tumour suppressor TRIM33 targets nuclear β-catenin degradation

Breadth of tuning in taste afferent neurons varies with stimulus strength

Rubrene crystal field-effect mobility modulation via conducting channel wrinkling

Arbitrary lattice symmetries via block copolymer nanomeshes

The water catalysis at oxygen cathodes of lithium–oxygen cells

Enhanced optoelectronic quality of perovskite thin films with hypophosphorous acid for planar heterojunction solar cells

The key role of the scaffold on the efficiency of dendrimer nanodrugs

Combined operando X-ray diffraction–electrochemical impedance spectroscopy detecting solid solution reactions of LiFePO4 in batteries

SCFβ-TRCP promotes cell growth by targeting PR-Set7/Set8 for degradation

Flexible thin-film black gold membranes with ultrabroadband plasmonic nanofocusing for efficient solar vapour generation

Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization

Physical principles of membrane remodelling during cell mechanoadaptation

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

Separation and conversion dynamics of nuclear-spin isomers of gaseous methanol

Temporal regulation of kin recognition maintains recognition-cue diversity and suppresses cheating

Phased-array sources based on nonlinear metamaterial nanocavities

mRIN for direct assessment of genome-wide and gene-specific mRNA integrity from large-scale RNA-sequencing data

Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterollevels

Eliminating material constraints for nonlinearity with plasmonic metamaterials

Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis

Bipyramid-templated synthesis of monodisperse anisotropic gold nanocrystals

Large magnetocaloric effect and adiabatic demagnetization refrigeration with YbPt2Sn

Exciton dynamics of C60-based single-photon emitters explored by Hanbury Brown–Twiss scanning tunnelling microscopy

Controllability of structural brain networks

Voxel-based morphometry predicts shifts in dendritic spine density and morphology with auditory fear conditioning

Reversed oxygen sensing using colloidal quantum wells towards highly emissive photoresponsive varnishes

Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells

A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration

MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection

Avalanching strain dynamics during the hydriding phase transformation in individual palladium nanoparticles

Large-volume en-bloc staining for electron microscopy-based connectomics

Topological control of the Caulobacter cell cycle circuitry by a polarized single-domain PAS protein

Competition between recombination and extraction of free charges determines the fill factor of organic solar cells

Structure of the native Sec61 protein-conducting channel

Vibrational spectroscopy at electrolyte/electrode interfaces with graphene gratings

Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser

Electronic polymers and soft-matter-like broken symmetries in underdoped cuprates

C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle

Ultra-low-power hybrid light–matter solitons

Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes

Bio-inspired electron-delivering system for reductive activation of dioxygen at metal centres towards artificial flavoenzymes

Sleep disruption impairs hematopoietic stem cell transplantation in mice

Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells

Volatile signalling by sesquiterpenes from ectomycorrhizal fungi reprogrammes root architecture

Translational diffusion of hydration water correlates with functional motions in folded and intrinsically disordered proteins

CRL4–DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation

Compound heterozygous mutations in the noncoding RNU4ATAC cause Roifman Syndrome by disrupting minor intron splicing

Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits

A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling

Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney

Reliable quantum certification of photonic state preparations

Stochasticity, periodicity and localized light structures in partially mode-locked fibre lasers

A scanning cavity microscope

Corrigendum: Duplication of a promiscuous transcription factor drives the emergence of a new regulatory network

Porous coordination polymers with ubiquitous and biocompatible metals and a neutralbridging ligand

Returners and explorers dichotomy in human mobility

Deep groundwater and potential subsurface habitats beneath an Antarctic dry valley

Kinetochore–microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint

The insulin and IGF1 receptor kinase domains are functional dimers in the activated state

Dynamic kirigami structures for integrated solar tracking

Swarming bacteria migrate by Lévy Walk

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

Coral record of southeast Indian Ocean marine heatwaves with intensified Western Pacific temperature gradient

Pressure-driven dome-shaped superconductivity and electronic structural evolution in tungsten ditelluride

Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours

Structural diversity of supercoiled DNA

Change in ocean subsurface environment to suppress tropical cyclone intensification under global warming

Morphological plasticity of the coral skeleton under CO2-driven seawater acidification

Opposing calcium dependent signaling pathways control skeletal muscle differentiation by regulating a chromatin remodeling enzyme

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

Membrane tension controls the assembly of curvature-generating proteins

Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline

An insight into non-emissive excited states in conjugated polymers

Spin–cavity interactions between a quantum dot molecule and a photonic crystal cavity

Regulated Degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer

Pliocene cooling enhanced by flow of low-salinity Bering Sea water to the Arctic Ocean

A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis

Ultra-sensitive all-fibre photothermal spectroscopy with large dynamic range

Erratum: Autophagy and endosomal trafficking inhibition by Vibrio cholerae MARTX toxin phosphatidylinositol-3-phosphate-specific phospholipase A1 activity

Geologic controls on supercritical geothermal resources above magmatic intrusions

Causative role of left aIPS in coding shared goals during human–avatar complementary joint actions

Formation of bimetallic clusters in superfluid helium nanodroplets analysed by atomic resolution electron tomography

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle

Topological states in multi-orbital HgTe honeycomb lattices

RNA regulatory networks diversified through curvature of the PUF protein scaffold

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

The Oncogenic MicroRNA miR-21 Promotes Regulated Necrosis in Mice

Kinase-independent role for CRAF-driving tumour radioresistance via CHK2

Climate variability modulates western US ozone air quality in spring via deep stratospheric intrusions

Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2

The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition

Kinesin-5 is a microtubule polymerase

Influence of chemical disorder on energy dissipation and defect evolution in concentrated solid solution alloys

The bacterial tubulin FtsZ requires its intrinsically disordered linker to direct robust cell wall construction

Interneuron- and GABAA receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells

Indole is an essential herbivore-induced volatile priming signal in maize

Transition of dislocation nucleation induced by local stress concentration in nanotwinned copper

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

A small-gap electrostatic micro-actuator for large deflections

A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis

Patterns and functional implications of rare germline variants across 12 cancer types

Carbonization of a stable β-sheet-rich silk protein into a pseudographitic pyroprotein

Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

Nanoparticles with photoinduced precipitation for the extraction of pollutants from water and soil

Abasic pivot substitution harnesses target specificity of RNA interference

Quadruple-junction lattice coherency and phase separation in a binary-phase system

Capping protein integrates multiple MAMP signalling pathways to modulate actin dynamics during plant innate immunity

Targeted DNA degradation using a CRISPR device stably carried in the host genome

Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity

eQTL mapping identify insertion and deletion specific eQTLs in multiple tissues

A synthetic hydrogel for the high-throughput study of cell–ECM interactions

Prospective errors determine motor learning

Total synthesis of palau'amine

RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

Dark-field X-ray microscopy for multiscale structural characterization

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging

Self-organizing human cardiac microchambers mediated by geometric confinement

Multivalency governs HP1α association dynamics with the silent chromatin state

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection

Transient misfolding dominates multidomain protein folding

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

Dynamic formation of single-atom catalytic active sites on ceria-supported gold nanoparticles

Ambipolar zinc-polyiodide electrolyte for a high-energy density aqueous redox flow battery

Thermodynamic controls of the Atlantic Niño

Exosomes released by keratinocytes modulate melanocyte pigmentation

Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling

Herbivory increases diversification across insect clades

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

Episodic entrainment of deep primordial mantle material into ocean island basalts

Testing necessary regional frontal contributions to value assessment and fixation-based updating

Spin-orbit engineering in transition metal dichalcogenide alloy monolayers

Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy

Genetic control of morphometric diversity in the maize shoot apical meristem

The minimal work cost of information processing

Silicon carbide-free graphene growth on silicon for lithium-ion battery with high volumetric energy density

Mapping molecules in scanning far-field fluorescence nanoscopy

Storage of multiple single-photon pulses emitted from a quantum dot in a solid-state quantum memory

Erratum: The genomics of ecological vicariance in threespine stickleback fish

Visualizing cellular imaging data using PhenoPlot

Purely organic electroluminescent material realizing 100% conversion from electricity to light

High-performance mussel-inspired adhesives of reduced complexity

A splicing variant of Merlin promotes metastasis in hepatocellular carcinoma

A tunable azine covalent organic framework platform for visible light-induced hydrogen generation

The positive piezoconductive effect in graphene

Regional climate impacts of a possible future grand solar minimum

Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities

Early Pliocene onset of modern Nordic Seas circulation related to ocean gateway changes

Real-space collapse of a polariton condensate

Quantitative interactome analysis reveals a chemoresistant edgotype

Quantum ferroelectricity in charge-transfer complex crystals

Reversible gating of smart plasmonic molecular traps using thermoresponsive polymers for single-molecule detection

Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules

Subwavelength imaging through ion-beam-induced upconversion

Genetic mapping uncovers cis-regulatory landscape of RNA editing

Fundamental differences between glassy dynamics in two and three dimensions

Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances

Antarctic glacio-eustatic contributions to late Miocene Mediterranean desiccation and reflooding

Ionization-induced annealing of pre-existing defects in silicon carbide

An allosteric photoredox catalyst inspired by photosynthetic machinery

Atomistic mechanisms of nonstoichiometry-induced twin boundary structural transformation in titanium dioxide

Muscarinic Acetylcholine Receptor M3 Modulates Odorant Receptor Activity via Inhibition of β-Arrestin-2 Recruitment

Migration and horizontal gene transfer divide microbial genomes into multiple niches

Lineage Specification of Ovarian Theca Cells Requires Multi-Cellular Interactions via Oocyte and Granulosa Cells

Widespread disruption of host transcription termination in HSV-1 infection

Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2

Ambient solid-state mechano-chemical reactions between functionalized carbon nanotubes

Thermogenesis-triggered seed dispersal in dwarf mistletoe

Enterohemorrhagic Escherichia coli senses low biotin status in the large intestine for colonization and infection

Direct evidence for a pressure-induced nodal superconducting gap in the Ba0.65Rb0.35Fe2As2 superconductor

Turning bubbles on and off during boiling using charged surfactants

Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements

Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism

ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning

Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis

Tropical Atlantic temperature seasonality at the end of the last interglacial

Single-photon sensitive light-in-fight imaging

Neutral particle mass spectrometry with nanomechanical systems

DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age

Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis

Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA

TCR ITAM multiplicity is required for the generation of follicular helper T-cells

Multiplex lithography for multilevel multiscale architectures and its application to polymer electrolyte membrane fuel cell

Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M

High yield and ultrafast sources of electrically triggered entangled-photon pairs based on strain-tunable quantum dots

Divergent sorting of a balanced ancestral polymorphism underlies the establishment of gene-flow barriers in Capsella

Immunological biomarkers predict HIV-1 viral rebound after treatment interruption

Topological states on the gold surface

Fennoscandian freshwater control on Greenland hydroclimate shifts at the onset of the Younger Dryas

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

Coherent quantum depletion of an interacting atom condensate

Sensitive β-galactosidase-targeting fluorescence probe for visualizing small peritoneal metastatic tumours in vivo

A Scalable and Operationally Simple Radical Trifluoromethylation

Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity

Multilevel animal societies can emerge from cultural transmission

Islands contribute disproportionately high amounts of evolutionary diversity in passerine birds

Monolayered Bi2WO6 nanosheets mimicking heterojunction interface with open surfaces for photocatalysis

Two-dimensional membrane as elastic shell with proof on the folds revealed by three-dimensional atomic mapping

Direct observation of multistep energy transfer in LHCII with fifth-order 3D electronic spectroscopy

Hybrid integrated biological–solid-state system powered with adenosine triphosphate

Theory and computation of hot carriers generated by surface plasmon polaritons in noble metals

Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear

Quantification of thickness and wrinkling of exfoliated two-dimensional zeolite nanosheets

Magnetotactic molecular architectures from self-assembly of β-peptide foldamers

Interplay between glucose and leptin signaling determines the strength of GABAergic synapses at POMC neurons

Adiabatic Far Field Sub-Diffraction Imaging

Single-molecule chemo-mechanical unfolding reveals multiple transition state barriers in a small single-domain protein

Systematic evaluation of an atomic clock at 2 × 10−18 total uncertainty

Genome-wide Association Study Identifies Peanut Allergy-Specific Loci and Evidence of Epigenetic Mediation in U.S. Children

Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly

Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries

Multivariate selection drives concordant patterns of pre- and postcopulatory sexual selection in a livebearing fish

High rate and stable cycling of lithium metal anode

PH motifs in PAR1&2 endow breast cancer growth

High-performance flexible perovskite solar cells exploiting Zn2SnO4 prepared in solution below 100 °C

The impact of DNA intercalators on DNA and DNA-processing enzymes elucidated through force-dependent binding kinetics

A self-healable and highly stretchable supercapacitor based on a dual crosslinked polyelectrolyte

Epigenomic evolution in diffuse large B-cell lymphomas

A lead-halide perovskite molecular ferroelectric semiconductor

Femtosecond all-optical synchronization of an X-ray free-electron laser

Ultrahigh sensitivity and layer-dependent sensing performance of phosphorene-based gas sensors

S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength

Local cooling and warming effects of forests based on satellite observations

Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

Two routes to senescence revealed by real-time analysis of telomerase-negative single lineages

Nonlinear spin-wave excitations at low magnetic bias fields

Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate

Shadows of anyons and the entanglement structure of topological phases

Metastable orientational order of colloidal discoids

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer

Multiply periodic states and isolated skyrmions in an anisotropic frustrated magnet

Atomistic understandings of reduced graphene oxide as an ultrathin-film nanoporous membrane for separations

Digital microfluidic immunocytochemistry in single cells

Cognitive tutoring induces widespread neuroplasticity and remediates brain function in children with mathematical learning disabilities

Open–closed switching of synthetic tubular pores

Cyclic stretching of soft substrates induces spreading and growth

Retrieving spin textures on curved magnetic thin films with full-field soft X-ray microscopies

Real-time observation of epitaxial graphene domain reorientation

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

Bond cleavage, fragment modification and reassembly in enantioselective three-component reactions

TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair

Lipid-bilayer-assisted two-dimensional self-assembly of DNA origami nanostructures

Efficient direct solar-to-hydrogen conversion by in situ interface transformation of a tandem structure

In-operando high-speed tomography of lithium-ion batteries during thermal runaway

An octave-spanning mid-infrared frequency comb generated in a silicon nanophotonic wire waveguide

MYC-induced reprogramming of glutamine catabolism supports optimal virus replication

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex

CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells

Bifunctional non-noble metal oxide nanoparticle electrocatalysts through lithium-induced conversion for overall water splitting

Real-time fluorescence imaging with 20 nm axial resolution

Quasiparticle spin resonance and coherence in superconducting aluminium

Photoreactive helical nanoaggregates exhibiting morphology transition on thermal reconstruction

DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression

NSD1 mutations generate a genome-wide DNA methylation signature

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

Structural insight into the mechanism of synergistic autoinhibition of SAD kinases

Silane-catalysed fast growth of large single-crystalline graphene on hexagonal boron nitride

Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation

Snf1/AMP-activated protein kinase activates Arf3p to promote invasive yeast growth via a non-canonical GEF domain

Human-to-mosquito transmission efficiency increases as malaria is controlled

Microsecond-sustained lasing from colloidal quantum dot solids

Production of butyrate from lysine and the Amadori product fructoselysine by a human gut commensal

Multiple-exciton generation in lead selenide nanorod solar cells with external quantum efficiencies exceeding 120%

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromalmacrophages

Lead iodide perovskite light-emitting field-effect transistor

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel

Dendritic cells induce Th2-mediated airway inflammatory responses to housedust mite via DNA-dependent protein kinase

Polymer-metal hybrid transparent electrodes for flexible electronics

Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation

Efficient light emission from inorganic and organic semiconductor hybrid structures by energy-level tuning

Activating CAR and β-Catenin Induces Uncontrolled Liver Growth and Tumorigenesis

Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection

Rise to modern levels of ocean oxygenation coincided with the Cambrian radiation of animals

Glycan complexity dictates microbial resource allocation in the large intestine

Reconciling spatial and temporal soil moisture effects on afternoon rainfall

Superstatistical analysis and modelling of heterogeneous random walks

Programmable definition of nanogap electronic devices using self-inhibited reagent depletion

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C

A dual-isotope approach to allow conclusive partitioning between three sources

A high-throughput optomechanical retrieval method for sequence-verified clonal DNA from the NGS platform

Atomically controlled substitutional boron-doping of graphene nanoribbons

Control of coherent information via on-chip photonic–phononic emitter–receivers

Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia

Surprising trunk rotational capabilities in chimpanzees and implications for bipedal walking proficiency in early hominins

TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

The experimental power of FR900359 to study Gq-regulated biological processes

Hyperspectral light sheet microscopy

TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation

Identification of new susceptibility loci for IgA nephropathy in Han Chinese

Evolutionary games of condensates in coupled birth–death processes

Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant

Noncontact friction via capillary shear interaction at nanoscale

Fibres and cellular structures preserved in 75-million–year-old dinosaur specimens

De novo mutations in PLXND1 and REV3L cause Möbius syndrome

Hydrophobic mismatch sorts SNARE proteins into distinct membrane domains

Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension

Collisional dynamics in a gas of molecular super-rotors

An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1

Cationic cluster formation versus disproportionation of low-valent indium and gallium complexes of 2,2'-bipyridine

RFX transcription factors are essential for hearing in mice

A genome-wide association study identifies multiple loci for variation in human ear morphology

Dominant oceanic bacteria secure phosphate using a large extracellular buffer

Comprehensive functional characterization of cancer–testis antigens definesobligate participation in multiple hallmarks of cancer

Single-molecule spectroscopy exposes hidden states in an enzymatic electron relay

Structure of a bacterial type III secretion system in contact with a host membrane in situ

Erratum: Whole-genome sequence-based analysis of thyroid function

Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation

KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR

Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase

SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes

Diverse synaptic plasticity mechanisms orchestrated to form and retrieve memories in spiking neural networks

Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model

On the tear resistance of skin

Using the transit of Venus to probe the upper planetary atmosphere

New Permian fauna from tropical Gondwana

Long-term neural and physiological phenotyping of a single human

Mutual information reveals multiple structural relaxation mechanisms in a model glass former

Asymmetric synthesis of syn-propargylamines and unsaturated β-amino acids under Brønsted base catalysis

Realization of a vertical topological p–n junction in epitaxial Sb2Te3/Bi2Te3 heterostructures

Direct observation of finite size effects in chains of antiferromagnetically coupled spins

Nano-guided cell networks as conveyors of molecular communication

MicroRNA–mRNA interactions underlying colorectal cancer molecular subtypes

Corrigendum: Rare coding variants and X-linked loci associated with age at menarche

Interplay between plasmon and single-particle excitations in a metal nanocluster

Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers

Formation of helical membrane tubes around microtubules by single-headed kinesin KIF1A

Supramolecular amplification of amyloid self-assembly by iodination

Magnetic moments induce strong phonon renormalization in FeSi

Self-assembly and electrostriction of arrays and chains of hopfion particles in chiral liquid crystals

Single-molecule imaging of a three-component ordered actin disassembly mechanism

Substrate specificity and transport mechanism of amino-acid transceptor Slimfast from Aedes aegypti

Cobalt-centred boron molecular drums with the highest coordination number in the CoB16 − cluster

Corrigendum: Rh D blood group conversion using transcription activator-like effector nucleases

The Cholesterol Transporter ABCG1 Links Cholesterol Homeostasis and Tumor Immunity

Field propagation-induced directionality of carrier-envelope phase-controlled photoemission from nanospheres

Hybrid glasses from strong and fragile metal-organic framework liquids

Topological data analysis of contagion maps for examining spreading processes on networks

Sub-nanosecond signal propagation in anisotropy-engineered nanomagnetic logic chains

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

Marine foods sourced from farther as their use of global ocean primary production increases

Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment

Climate variation explains a third of global crop yield variability

Modulation of the molecular spintronic properties of adsorbed copper corroles

Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases

Interaction-induced decay of a heteronuclear two-atom system

miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth

Quantum Monte Carlo study of the phase diagram of solid molecular hydrogen at extreme pressures

Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation

Exploring the phase diagram of the two-impurity Kondo problem

Functional classification of memory CD8+ T cells by CX3CR1 expression

Exploitation of desilylation chemistry in tailor-made functionalization on diverse surfaces

Corrigendum: Rethinking Indian monsoon rainfall prediction in the context of recent global warming

Real-time tunable lasing from plasmonic nanocavity arrays

A porous proton-relaying metal-organic framework material that accelerates electrochemical hydrogen evolution

Stripe-like nanoscale structural phase separation in superconducting BaPb1−x Bi x O3

Telomere maintenance through recruitment of internal genomic regions

Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study

Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues

High-quality bulk hybrid perovskite single crystals within minutes by inverse temperature crystallization

Accommodating lithium into 3D current collectors with a submicron skeleton towards long-life lithium metal anodes

Room-temperature in situ nuclear spin hyperpolarization from optically pumped nitrogen vacancy centres in diamond

Witnessing magnetic twist with high-resolution observation from the 1.6-m New Solar Telescope

Direct observation and temperature control of the surface Dirac gap in a topological crystalline insulator

Stable kinetochore–microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells

Characterizing entanglement of an artificial atom and a cavity cat state with Bell's inequality

An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma

Integrin-linked kinase regulates the niche of quiescent epidermal stem cells

Behavioural correlates of combinatorial versus temporal features of odour codes

Ultralow-threshold multiphoton-pumped lasing from colloidal nanoplatelets in solution

Direct electron injection into an oxide insulator using a cathode buffer layer

Generation of neutral and high-density electron–positron pair plasmas in the laboratory

A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance

Efficient near-infrared up-conversion photoluminescence in carbon nanotubes

Microscopic dynamics of synchronization in driven colloids

Arp2/3-mediated F-actin formation controls regulated exocytosis in vivo

Optofluidic fabrication for 3D-shaped particles

PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus

Corrigendum: Processing of visually evoked innate fear by a non-canonical thalamic pathway

O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth

Calcium-controlled conformational choreography in the N-terminal half of adseverin

A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae

Hepatic Insulin Signaling is Dispensable for Suppression of Glucose Output by Insulin in Vivo

Emergence of coherence in the charge-density wave state of 2H-NbSe2

Corrigendum: Size and frequency of natural forest disturbances and the Amazon forest carbon balance

Intracellular signalling and intercellular coupling coordinate heterogeneous contractile events to facilitate tissue folding

Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis

PTEN Regulates DNA Replication Progression and Stalled Fork Recovery

Preference for concentric orientations in the mouse superior colliculus

Fermi states and anisotropy of Brillouin zone scattering in the decagonal Al–Ni–Co quasicrystal

Effective heritable gene knockdown in zebrafish using synthetic microRNAs

Generalization of word meanings during infant sleep

Microsecond protein dynamics observed at the single-molecule level

AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

New streams and springs after the 2014 Mw6.0 South Napa earthquake

Carbon-depleted outer core revealed by sound velocity measurements of liquid iron–carbon alloy

Sub-microWatt threshold nanoisland lasers

Real-time tracking of cell cycle progression during CD8+ effector and memory T-cell differentiation

High-throughput 3D tracking of bacteria on a standard phase contrast microscope

Lgr5+ Cells Regenerate Hair Cells via Proliferation and Direct Transdifferentiation in Damaged Neonatal Mouse Utricle

Parent–offspring conflict and the genetic trade-offs shaping parental investment

Involvement of a eukaryotic-like ubiquitin-related modifier in the proteasome pathway of the archaeon Sulfolobus acidocaldarius

Auditory cortex controls sound-driven innate defense behaviour through corticofugal projections to inferior colliculus

Mechanics of epithelial closure over non-adherent environments

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins

Nonsynaptic junctions on myelinating glia promote preferential myelination of electrically active axons

GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane

Recombinase-based conditional and reversible gene regulation via XTR alleles

Hydride bridge in [NiFe]-hydrogenase observed by nuclear resonance vibrational spectroscopy

Visualizing the morphology of vortex lattice domains in a bulk type-II superconductor

Gekko japonicus genome reveals evolution of adhesive toe pads and tail regeneration

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing

A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins

Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM

Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA

Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction

Wearable red–green–blue quantum dot light-emitting diode array using high-resolution intaglio transfer printing

Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation

Polarization-resolved spectroscopy imaging of grain boundaries and optical excitations in crystalline organic thin films

Large interdomain rearrangement triggered by suppression of micro- to millisecond dynamics in bacterial Enzyme I

Saccadic modulation of stimulus processing in primary visual cortex

Demonstration of asymmetric electron conduction in pseudosymmetrical photosynthetic reaction centre proteins in an electrical circuit

A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development

Translational regulation shapes the molecular landscape of complex disease phenotypes

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

Phytochrome diversity in green plants and the origin of canonical plant phytochromes

Exclusive photorelease of signalling lipids at the plasma membrane

Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug

Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

Visualizing nanoscale excitonic relaxation properties of disordered edges and grain boundaries in monolayer molybdenum disulfide

DNA sequencing using polymerase substrate-binding kinetics

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

Enhancing grain boundary ionic conductivity in mixed ionic–electronic conductors

Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars

Scattering-type scanning near-field optical microscopy with reconstruction of vertical interaction

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

Atomically resolved real-space imaging of hot electron dynamics

Quantitative X-ray phase-contrast microtomography from a compact laser-driven betatron source

Evaluation of candidate vaccine approaches for MERS-CoV

General synthesis of inorganic single-walled nanotubes

Corrigendum: The immune synapse clears and excludes molecules above a size threshold

Hot electron-induced reduction of small molecules on photorecycling metal surfaces

Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control

PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium

Magnetically induced forward scattering at visible wavelengths in silicon nanosphere oligomers

Parallel circuits control temperature preference in Drosophila during ageing

Ultrafast visualization of crystallization and grain growth in shock-compressed SiO2

Food-web stability signals critical transitions in temperate shallow lakes

Jurassic climate mode governed by ocean gateway

Proposal for a room-temperature diamond maser

Dichroic spin–valley photocurrent in monolayer molybdenum disulphide

Fabrication of three-dimensionally interconnected nanoparticle superlattices and their lithium-ion storage properties

P2-Na0.6[Cr0.6Ti0.4]O2 cation-disordered electrode for high-rate symmetric rechargeable sodium-ion batteries

Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia

The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome

Strong piezoelectricity in single-layer graphene deposited on SiO2 grating substrates

Calorimetric determination of the magnetic phase diagram of underdoped ortho II YBa2Cu3O6.54 single crystals

‘Emergency exit' of bone-marrow-resident CD34+DNAM-1brightCXCR4+-committed lymphoid precursors during chronic infection and inflammation

TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport

Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cells

FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization

Structure–function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

A deuterostome origin of the Spemann organiser suggested by Nodal and ADMPs functions in Echinoderms

Onset of sediment transport is a continuous transition driven by fluid shear and granular creep

Magnetic fingerprint of individual Fe4 molecular magnets under compression by a scanning tunnelling microscope

Electrochemical polymerization of pyrene derivatives on functionalized carbon nanotubes for pseudocapacitive electrodes

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

Molecular architecture of native fibronectin fibrils

Eukaryotic opportunists dominate the deep-subsurface biosphere in South Africa

Surface determination through atomically resolved secondary-electron imaging

Tracking molecular resonance forms of donor–acceptor push–pull molecules by single-molecule conductance experiments

Flow-driven assembly of VWF fibres and webs in in vitro microvessels

Clinically relevant copy number variations detected in cerebral palsy

Mesoporous MnCeO x solid solutions for low temperature and selective oxidation of hydrocarbons

Detecting bit-flip errors in a logical qubit using stabilizer measurements

Developmental-stage-dependent transcriptional response to leukaemic oncogene expression

Exploring atomic defects in molybdenum disulphide monolayers

Understanding catalysis in a multiphasic two-dimensional transition metal dichalcogenide

Probing the target search of DNA-binding proteins in mammalian cells using TetR as model searcher

The sperm of aging male bustards retards their offspring's development

A Paclitaxel-Loaded Recombinant Polypeptide Nanoparticle Outperforms Abraxane in Multiple Murine Cancer Models

Ultralow noise miniature external cavity semiconductor laser

PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

Wall mechanics and exocytosis define the shape of growth domains in fission yeast

Experimental resource pulses influence social-network dynamics and the potential for information flow in tool-using crows

Artificial human Met agonists based on macrocycle scaffolds

Efficient photosynthesis of carbon monoxide from CO2 using perovskite photovoltaics

Mechanism of erosion of nanostructured porous silicon drug carriers in neoplastic tissues

Transcription Errors Induce Proteotoxic Stress and Shorten Cellular Lifespan

Nitrogen-embedded buckybowl and its assembly with C60

Erratum: Steady-state cross-correlations for live two-colour super-resolution localization data sets

Growth pattern from birth to adulthood in African pygmies of known age

Combined effects of recent Pacific cooling and Indian Ocean warming on the Asian monsoon

Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation

High-quality sandwiched black phosphorus heterostructure and its quantum oscillations

Demonstration of a quantum error detection code using a square lattice of four superconducting qubits

Cold-sensing regulates Drosophila growth through insulin-producing cells

Observing the overall rocking motion of a protein in a crystal

Ultrafast multidimensional Laplace NMR for a rapid and sensitive chemical analysis

Three-dimensional magnetic cloak working from d.c. to 250 kHz

High-intensity double-pulse X-ray free-electron laser

Vimentin filament organization and stress sensing depend on its single cysteine residue and zinc binding

A hot-electron thermophotonic solar cell demonstrated by thermal up-conversion of sub-bandgap photons

Real-time observation of domain fluctuations in a two-dimensional magnetic model system

Spin-stripe phase in a frustrated zigzag spin-1/2 chain

Scanning precession electron tomography for three-dimensional nanoscale orientation imaging and crystallographic analysis

Single-step fabrication of quantum funnels via centrifugal colloidal casting of nanoparticle films

Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

Wave energy budget analysis in the Earth's radiation belts uncovers a missing energy

Epstein–Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma

Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

Allostery through the computational microscope: cAMP activation of a canonical signaling domain

C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling

STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling

GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters

Structural isomserism in gold nanoparticles revealed by X-ray crystallography

ALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP

SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression

Acoustic metamaterial for subwavelength edge detection

A photofunctional bottom-up bis(dipyrrinato)zinc(II) complex nanosheet

Optogenetic control of contractile function in skeletal muscle

Dose–response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies

Plasticity and ductility in graphene oxide through a mechanochemically induced damage tolerance mechanism

Collaborative rewiring of the pluripotency network by chromatin and signalling modulating pathways

Long distance spin communication in chemical vapour deposited graphene

Structural basis for catalytically restrictive dynamics of a high-energy enzyme state

Room-temperature carbon monoxide oxidation by oxygen over Pt/Al2O3 mediated by reactive platinum carbonates

Ultrafast helicity control of surface currents in topological insulators with near-unity fidelity

Terahertz field control of in-plane orbital order in La0.5Sr1.5MnO4

The iBeetle large-scale RNAi screen reveals gene functions for insect development and physiology

MicroRNA-146a regulates ICOS–ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres

Contextual modulation of value signals in reward and punishment learning

Paleoproterozoic high-pressure metamorphism in the northern North China Craton and implications for the Nuna supercontinent

Hydrodynamic schooling of flapping swimmers

Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas

MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3

Nano-socketed nickel particles with enhanced coking resistance grown in situ by redox exsolution

Transgranular liquation cracking of grains in the semi-solid state

Imperceptible magnetoelectronics

NFκB1 is a suppressor of neutrophil-driven hepatocellularcarcinoma

Molecular interactions on single-walled carbon nanotubes revealed by high-resolution transmission microscopy

Superlattices assembled through shape-induced directional binding

A monotopic aluminum telluride with an Al=Te double bond stabilized by N-heterocyclic carbenes

Defective titanium dioxide single crystals exposed by high-energy {001} facets for efficient oxygen reduction

Chemical structure imaging of a single molecule by atomic force microscopy at room temperature

eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference

Dynamic labelling of neural connections in multiple colours by trans-synaptic fluorescence complementation

Delivery of crop pollination services is an insufficient argument for wild pollinator conservation

Holographic acoustic elements for manipulation of levitated objects

A portable expression resource for engineering cross-species genetic circuits and pathways

Dirac surface states and nature of superconductivity in Noncentrosymmetric BiPd

Upper Palaeolithic genomes reveal deep roots of modern Eurasians

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels

A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles

Targeted diversity generation by intraterrestrial archaea and archaeal viruses

Direct observation of ultrafast coherent exciton dynamics in helical π-stacks of self-assembled perylene bisimides

Hong-Ou-Mandel experiment for temporal investigation of single-electron fractionalization

Resident c-kit+ cells in the heart are not cardiac stem cells

Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression

Optical control of NMDA receptors with a diffusible photoswitch

Top consumer abundance influences lake methane efflux

Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance

Towards outperforming conventional sensor arrays with fabricated individual photonic vapour sensors inspired by Morpho butterflies

Modular pathway rewiring of Saccharomyces cerevisiae enables high-level production of L-ornithine

Edge-mediated skyrmion chain and its collective dynamics in a confined geometry

Large-scale recent expansion of European patrilineages shown by population resequencing

Observation of correlated electronic decay in expanding clusters triggered by near-infrared fields

Stereomicroscopic 3D-pattern profiling of murine and human intestinal inflammation reveals unique structural phenotypes

Vinculin controls talin engagement with the actomyosin machinery

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

Osmosensing and scaffolding functions of the oligomeric four-transmembrane domain osmosensor Sho1

Ultrasensitive and label-free molecular level detection enabled by light phase control in magnetoplasmonic nanoantennas

Calcium ions open a selectivity filter gate during activation of the MthK potassium channel

Intrinsically disordered proteins drive membrane curvature

Strong frequency dependence of vibrational relaxation in bulk and surface water reveals sub-picosecond structural heterogeneity

Humidity-enhanced wet adhesion on insect-inspired fibrillar adhesive pads

X-ray structure and activities of an essential Mononegavirales L-protein domain

Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7

Electrical behaviour of dendritic spines as revealed by voltage imaging

Positive-bias gate-controlled metal–insulator transition in ultrathin VO2 channels with TiO2 gate dielectrics

Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome

Solution-printed organic semiconductor blends exhibiting transport properties on par with single crystals

A tyrosine–tryptophan dyad and radical-based charge transfer in a ribonucleotide reductase-inspired maquette

Magneto-optical investigation of spin–orbit torques in metallic and insulating magnetic heterostructures

Magnetic microscopy and topological stability of homochiral Néel domain walls in a Pt/Co/AlO x trilayer

Corrigendum: Enhanced role of eddies in the Arctic marine biological pump

Ultrastrong ductile and stable high-entropy alloys at small scales

Electromechanical oscillations in bilayer graphene

Analysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms

Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ–IL1RAPL1/IL-1RAcP for synaptic differentiation

9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate

Grb2 monomer–dimer equilibrium determines normal versus oncogenic function

Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic

Osmotic pressure induced tensile forces in tendon collagen

Light-induced pyroelectric effect as an effective approach for ultrafast ultraviolet nanosensing

The evolution of cyclopropenium ions into functional polyelectrolytes

Observation of directly interacting coherent two-level systems in an amorphous material

System-wide identification of wild-type SUMO-2 conjugation sites

Coherent coupling of molecular resonators with a microcavity mode

Emergent vortices in populations of colloidal rollers

Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo

Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue

Wearable energy-dense and power-dense supercapacitor yarns enabled by scalable graphene–metallic textile composite electrodes

Active control of all-fibre graphene devices with electrical gating

Tuning magnetotransport in a compensated semimetal at the atomic scale

Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site

Intestinal macrophages arising from CCR2+ monocytes control pathogen infection by activating innate lymphoid cells

Macrotene chromosomes provide insights to a new mechanism of high-order gene amplification in eukaryotes

Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine

Polaron pair mediated triplet generation in polymer/fullerene blends

Convergent capture of retroviral superantigens by mammalian herpesviruses

High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

Target engagement and drug residence time can be observed in living cells with BRET

Conjugated polyelectrolyte hole transport layer for inverted-type perovskite solar cells

Storage and retrieval of vector beams of light in a multiple-degree-of-freedom quantum memory

Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase

Electron paramagnetic resonance imaging for real-time monitoring of Li-ion batteries

Visualizing real-time influenza virus infection, transmission and protection in ferrets

Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes

Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling

Carbon-bridged oligo(p-phenylenevinylene)s for photostable and broadly tunable, solution-processable thin film organic lasers

In vivo capture and label-free detection of early metastatic cells

Free mate choice enhances conservation breeding in the endangered giant panda

Structural optimization of 3D-printed synthetic spider webs for high strength

Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo

Spanning the scales of granular materials through microscopic force imaging

Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors

Three-dimensional nanoscale molecular imaging by extreme ultraviolet laser ablation mass spectrometry

The seasonal sea-ice zone in the glacial Southern Ocean as a carbon sink

Stem and progenitor cell division kinetics during postnatal mouse mammary gland development

Magnetic crystals and helical liquids in alkaline-earth fermionic gases

Imaging with a small number of photons

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls

Mechanical work makes important contributions to surface chemistry at steps

Highly porous non-precious bimetallic electrocatalysts for efficient hydrogen evolution

Mitochondrial function provides instructive signals for activation-induced B-cell fates

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells

A spectrally tunable all-graphene-based flexible field-effect light-emitting device

Dipeptide species regulate p38MAPK–Smad3 signalling to maintain chronic myelogenous leukaemia stem cells

Corrigendum: Inclusion flotation-driven channel segregation in solidifying steels

CD24 tracks divergent pluripotent states in mouse and human cells

Anisotropic in-plane thermal conductivity of black phosphorus nanoribbons at temperatures higher than 100 K

Evidence of liquid–liquid transition in glass-forming La50Al35Ni15 melt above liquidus temperature

Landau level splitting in Cd3As2 under high magnetic fields

Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes

Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway

Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility

Comprehensive Bio-Imaging with Fluorinated Nanoparticles Using Breathable Liquids

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster

Decarbonylative organoboron cross-coupling of esters by nickel catalysis

Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer

Hydrologically driven ecosystem processes determine the distribution and persistence of ecosystem-specialist predators under climate change

Erratum: Nanometre-scale probing of spin waves using single electron spins

Atomic view of the histidine environment stabilizing higher-pH conformations of pH-dependent proteins

Unravelling the physics of size-dependent dislocation-mediated plasticity

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer

Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species

Ambient seafloor noise excited by earthquakes in the Nankai subduction zone

Functional group diversity increases with modularity in complex food webs

Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody

Predicting the stability of large structured food webs

PDGFRβ signaling regulates local inflammation and synergizes with hypercholesterolemia to promote atherosclerosis

Perpendicular reading of single confined magnetic skyrmions

Causal factors for seismicity near Azle, Texas

Boundaries can steer active Janus spheres

Notch1-Dll4 signaling and mechanical force regulate leader cell formation during collective cell migration

Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy

Proinflammatory TLR signaling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages

Five-fold symmetry as indicator of dynamic arrest in metallic glass-forming liquids

Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1

Reversible amorphization and the catalytically active state of crystalline Co3O4 during oxygen evolution

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

Dual-topology insertion of a dual-topology membrane protein

Charge-transfer crystallites as molecular electrical dopants

Femtosecond structural transformation of phase-change materials far from equilibrium monitored by coherent phonons

All-photonic quantum repeaters

Patterning two-dimensional free-standing surfaces with mesoporous conducting polymers

Genomic landscape of pediatric adrenocortical tumors

Epigenetic and transcriptional determinants of the human breast

Allometric growth in the extant coelacanth lung during ontogenetic development

A two-dimensional π–d conjugated coordination polymer with extremely high electrical conductivity and ambipolar transport behaviour

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory–inhibitory synapse formation in the mature cortex

Metabotropic GABA signalling modulates longevity in C. elegans

Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis

Unambiguous detection of nitrated explosive vapours by fluorescence quenching of dendrimer films

Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis

Ultrafast spin exchange-coupling torque via photo-excited charge-transfer processes

The desensitization gate of inhibitory Cys-loop receptors

Snake trajectories in ultraclean graphene p–n junctions

Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

The optoelectronic role of chlorine in CH3NH3PbI3(Cl)-based perovskite solar cells

Platinum–nickel frame within metal-organic framework fabricated in situ for hydrogen enrichment and molecular sieving

Low-temperature-processed efficient semi-transparent planar perovskite solar cells for bifacial and tandem applications

Quantifying randomness in real networks

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

Strongly enhanced oxygen ion transport through samarium-doped CeO2 nanopillars in nanocomposite films

The low-affinity complex of cytochrome c and its peroxidase

Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I

Combined crystal structure prediction and high-pressure crystallization in rational pharmaceutical polymorph screening

Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure

Batf is important for IL-4 expression in T follicular helper cells

Accurate lineshape spectroscopy and the Boltzmann constant

Breaking of the site-bond percolation universality in networks

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence

The foot of Homo naledi

Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice

Enhancing the magnetic anisotropy of maghemite nanoparticles via the surface coordination of molecular complexes

Charge density wave transition in single-layer titanium diselenide

Increased CRF signaling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal

The pervasive role of biological cohesion in bedform development

Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein

Electric eels use high-voltage to track fast-moving prey

Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan

Cavity-less on-chip optomechanics using excitonic transitions in semiconductor heterostructures

CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis

Dendritic geometry shapes neuronal cAMP signalling to the nucleus

Engineering two-dimensional superconductivity and Rashba spin–orbit coupling in LaAlO3/SrTiO3 quantum wells by selective orbital occupancy

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

Detecting anthropogenic footprints in sea level rise

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection

Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3

Ultimate thin vertical p–n junction composed of two-dimensional layered molybdenum disulfide

Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules

Seasonality in submesoscale turbulence

Retraction: An actin-dependent spindle position checkpoint ensures the asymmetric division in mouse oocytes

Self-Assembled Hydrogels Utilising Polymer-Nanoparticle Interactions

Reconfigurable radio-frequency arbitrary waveforms synthesized in a silicon photonic chip

Acceptorless dehydrogenation of small molecules through cooperative base metal catalysis

Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization

TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production

Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours

Single neuron activity and eye movements during human REM sleep and awake vision

Insect glycerol transporters evolved by functional co-option and gene replacement

Observing in space and time the ephemeral nucleation of liquid-to-crystal phase transitions

SCARECROW-LIKE15 interacts with HISTONE DEACETYLASE19 and is essential for repressing the seed maturation programme

Giant anisotropic magnetoresistance in a quantum anomalous Hall insulator

Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus

Saturated fatty-acids regulate retinoic acid signaling and suppress tumorigenesis by targeting fatty-acid-binding protein 5

Neuronal and behavioural modulations by pathway-selective optogenetic stimulation of the primate oculomotor system

A molecular catalyst for water oxidation that binds to metal oxide surfaces

Direct observation of titanium-centered octahedra in titanium–antimony–tellurium phase-change material

Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells

A generic strategy for CRISPR-Cas9-mediated gene tagging

Irreversibly increased nitrogen fixation in Trichodesmium experimentally adapted to elevated carbon dioxide

Erratum: Flow damping due to stochastization of the magnetic field

Universal self-field critical current for thin-film superconductors

Surface faceting and elemental diffusion behaviour at atomic scale for alloy nanoparticles during in situ annealing

Oriented cell division shapes carnivorous pitcher leaves of Sarracenia purpurea

TGF-β3-expressingCD4+CD25−LAG3+ regulatory T cells controlhumoral immune responses

Soft network composite materials with deterministic and bio-inspired designs

Reactivation of IgG-switched memory B cells by BCR-intrinsic signal amplification promotes IgG antibody production

Metabolic learning and memory formation by the brain influence systemic metabolic homeostasis

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

The outer mucus layer hosts a distinct intestinal microbial niche

Engulfment pathways promote programmed cell death by enhancing the unequal segregation of apoptotic potential

STAT3-mediated IGF-2 secretion in the tumour microenvironment elicits innate resistance to anti-IGF-1R antibody

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

Ultrafast collisional ion heating by electrostatic shocks

Efficient purification of ethene by an ethane-trapping metal-organic framework

Multifractality of random eigenfunctions and generalization of Jarzynski equality

A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia

Synthesis of large-area multilayer hexagonal boron nitride for high material performance

Transcriptomes of parents identify parenting strategies and sexual conflict in a subsocial beetle

Force-induced chemical reactions on the metal centre in a single metalloprotein molecule

All-photonic intercity quantum key distribution

Unravelling the hidden ancestry of American admixed populations

Three-dimensional positioning and control of colloidal objects utilizing engineered liquid crystalline defect networks

Atomic-level characterization of transport cycle thermodynamics in the glycerol-3-phosphate:phosphate antiporter

The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles

Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization

Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway

Measuring fast stochastic displacements of bio-membranes with dynamic optical displacement spectroscopy

Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Disparate ultrafast dynamics of itinerant and localized magnetic moments in gadolinium metal

Erratum: A molecular propeller effect for chiral separation and analysis

Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing

The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming

14-3-3ζ coordinates adipogenesis of visceral fat

Unconventional transformation of spin Dirac phase across a topological quantum phase transition

Dynamic control of chirality in phosphine ligands for enantioselective catalysis

Single Abrikosov vortices as quantized information bits

Subdiffractional focusing and guiding of polaritonic rays in a natural hyperbolic material

The foundations of the human cultural niche

Directional cell movement through tissues is controlled by exosome secretion

Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment

Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese

Increasing water cycle extremes in California and in relation to ENSO cycle under global warming

Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria

Aneuploidy causes premature differentiation of neural and intestinal stem cells

Printable elastic conductors with a high conductivity for electronic textile applications

1,3,2,5-Diazadiborinine featuring nucleophilic and electrophilic boron centres

RTN1 mediates progression of kidney disease by inducing ER stress

Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate

Structural prerequisites for G-protein activation by the neurotensin receptor

Ape parasite origins of human malaria virulence genes

Infrared identification of the Criegee intermediates syn- and anti-CH3CHOO, and their distinct conformation-dependent reactivity

Unusual fast secondary relaxation in metallic glass

Dietary restriction protects against experimental cerebral malaria via leptin modulation and T cell mTORC1 suppression

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis

A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration

Optically initialized robust valley-polarized holes in monolayer WSe2

Chirality-selected phase behaviour in ionic polypeptide complexes

Charge-order domain walls with enhanced conductivity in a layered manganite

Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation

Colloidal metasurfaces displaying near-ideal and tunable light absorbance in the infrared

Tracing the fate of carbon and the atmospheric evolution of Mars

Supramolecular gels with high strength by tuning of calix[4]arene-derived networks

Genetic blueprint of the zoonotic pathogen Toxocara canis

Spatial and temporal changes in cumulative human impacts on the world's ocean

Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI

Revealing the role of organic cations in hybrid halide perovskite CH3NH3PbI3

Free energy landscape of activation in a signaling protein at atomic resolution

Strong interface-induced spin–orbit interaction in graphene on WS2

Farnesoid X Receptor Inhibits Glucagon-Like Peptide-1 Production by Enteroendocrine L-cells

Generation of cellular immune memory and B-cell immunity are impaired by natural killer cells

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase

Extreme 13C depletion of carbonates formed during oxidation of biogenic methane in fractured granite

Flexible, highly efficient all-polymer solar cells

The assembly dynamics of the cytolytic pore toxin ClyA

Mechanism of potassium ion uptake by theNa+/K+-ATPase

Rhodium-catalysed C(sp 2)–C(sp 2) bond formation via C–H/C–F activation

Three-terminal heterojunction bipolar transistor solar cell for high-efficiency photovoltaic conversion

Innate sensing of microbial products promotes wound-induced skin cancer

Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing

Multinuclear metal-binding ability of a carotene

Maintenance of Protein Synthesis Reading Frame by EF-P and m1G37-tRNA

An efficient molybdenum disulfide/cobalt diselenide hybrid catalyst for electrochemical hydrogen generation

Mechanical instability of monocrystalline and polycrystalline methane hydrates

Electrical detection of ortho–para conversion in fullerene-encapsulated water

The precision of value-based choices depends causally on fronto-parietal phase coupling

Reversible adapting layer produces robust single-crystal electrocatalyst for oxygen evolution

Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin

Pressure induced metallization with absence of structural transition in layered molybdenum diselenide

Cooperation is related to dispersal patterns in Sino-Tibetan populations

Plant macrofossil evidence for an early onset of the Holocene summer thermal maximum in northernmost Europe

Rethinking Indian monsoon rainfall prediction in the context of recent global warming

Bird embryos uncover homology and evolution of the dinosaur ankle

Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology

Fluctuations between multiple EF-G-induced chimeric tRNA states during translocation on the ribosome

Fluid shear triggers microvilli formation via mechanosensitive activation of TRPV6

Targeting protein tyrosine phosphatase σ after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias

IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst

Presynaptic spinophilin tunes neurexin signalling to control active zone architectureand function

Both respiration and photosynthesis determine the scaling of plankton metabolism in the oligotrophic ocean

Total synthesis of periploside A, a unique pregnane hexasaccharide with potent immunosuppressive effects

mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3

The a.c. Josephson effect without superconductivity

Highly active and durable methanol oxidation electrocatalyst based on the synergy of platinum–nickel hydroxide–graphene

A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus

Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1

Utilization of ancient permafrost carbon in headwaters of Arctic fluvial networks

A rapid bioluminescence assay for measuring myeloperoxidase activity in human plasma

T7 replisome directly overcomes DNA damage

Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction

Spatial and temporal imaging of long-range charge transport in perovskite thin films by ultrafast microscopy

Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement

Reconstitution and structure of a bacterial Pnkp1–Rnl–Hen1 RNA repair complex

Systematic functional profiling of transcription factor networks in Cryptococcus neoformans

Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase

Solar forcing synchronizes decadal North Atlantic climate variability

Slab rollback orogeny in the Alps and evolution of the Swiss Molasse basin

Auditory feedback blocks memory benefits of cueing during sleep

Erratum: Single-photon sensitive light-in-flight imaging

Aerosol influence on energy balance of the middle atmosphere of Jupiter

Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients

Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation

Glycopeptide Analogues of PSGL-1 Inhibit P-Selectin In Vitro and In Vivo

Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury

Nanoscale probing of image-dipole interactions in a metallic nanostructure

Biodiversity enhances ecosystem multifunctionality across trophic levels and habitats

Erratum: Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis

Inhibition of stationary phase respiration impairs persister formation in E. coli

Orbital reconstruction in nonpolar tetravalent transition-metal oxide layers

A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes

Coherent creation and destruction of orbital wavepackets in Si:P with electrical and optical read-out

Highly tunable hybrid metamaterials employing split-ring resonators strongly coupled to graphene surface plasmons

Strong coronal channelling and interplanetary evolution of a solar storm up to Earth and Mars

Anisotropic in-plane thermal conductivity observed in few-layer black phosphorus

Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions

Multiparametric AFM reveals turgor-responsive net-like peptidoglycan architecture in live streptococci

A stem acrodontan lizard in the Cretaceous of Brazil revises early lizard evolution in Gondwana

Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases

Protein conformational plasticity and complex ligand-binding kinetics explored by atomistic simulations and Markov models

A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation

HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus

One-shot K-region-selective annulative π-extension for nanographene synthesis and functionalization

Linking megathrust earthquakes to brittle deformation in a fossil accretionary complex

Photonic crystals cause active colour change in chameleons

Electride support boosts nitrogen dissociation over ruthenium catalyst and shifts the bottleneck in ammonia synthesis

Towards an unbiased view of science

On the decline of biodiversity due to area loss

LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase

V1 neurons respond differently to object motion versus motion from eye movements

Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels

Weak linkage between the heaviest rainfall and tallest storms

Investigation of exotic stable calcium carbides using theory and experiment

Size dependence of phase transitions in aerosol nanoparticles

Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

Giant colloidal silver crystals for low-loss linear and nonlinear plasmonics

Dynamic structural evolution of supported palladium–ceria core–shell catalysts revealed by in situ electron microscopy

Molecular development of chondrichthyan claspers and the evolution of copulatory organs

XUV excitation followed by ultrafast non-adiabatic relaxation in PAH molecules as a femto-astrochemistry experiment

Imaging thermal conductivity with nanoscale resolution using a scanning spin probe

Salicylic acid biosynthesis is enhanced and contributes to increased biotrophic pathogen resistance in Arabidopsis hybrids

Conformational gating of DNA conductance

The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Liquid crystals for organic thin-film transistors

Label-free in vivo molecular imaging of underglycosylated mucin-1 expression in tumour cells

An Xist-activating antisense RNA required for X-chromosome inactivation

The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins

Insights into the origin of the nuclear localization signals in conserved ribosomal proteins

Nanoscale measurements of unoccupied band dispersion in few-layer graphene

Macroscopic and high-throughput printing of aligned nanostructured polymer semiconductors for MHz large-area electronics

Coherent perfect absorption in deeply subwavelength films in the single-photon regime

Interaction-free measurements by quantum Zeno stabilization of ultracold atoms

TORC1 controls G1–S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway

Limited dissemination of the wastewater treatment plant core resistome

Planctomycetes do possess a peptidoglycan cell wall

Aqueous proton transfer across single-layer graphene

Global biomass production potentials exceed expected future demand without the need for cropland expansion

Choice-correlated activity fluctuations underlie learning of neuronal category representation

Parts-per-million level loading organocatalysed enantioselective silylation of alcohols

A predictive structural model for bulk metallic glasses

Observation of finite-wavelength screening in high-energy-density matter

Highly efficient and ultra-broadband graphene oxide ultrathin lenses with three-dimensional subwavelength focusing

Nanoscale control of phonon excitations in graphene

Graphene-enabled electron microscopy and correlated super-resolution microscopy of wet cells

3D hotspots of recurrent retroviral insertions reveal long-range interactions with cancer genes

Concentration- and chromosome-organization-dependent regulator unbinding from DNA for transcription regulation in living cells

STAT3 regulated ARF expression suppresses prostate cancer metastasis

A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning

Probing long-range carrier-pair spin–spin interactions in a conjugated polymer by detuning of electrically detected spin beating

Molecular snapshots of the Pex1/6 AAA+ complex in action

The NOXA–MCL1–BIM axis defines lifespan on extended mitotic arrest

Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells

Helicity multiplexed broadband metasurface holograms

Stability of single skyrmionic bits

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

Wet-chemical synthesis and applications of non-layer structured two-dimensional nanomaterials

Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier

Activating MET Kinase Rearrangements in Melanoma and Spitz Tumors

Talc-dominated seafloor deposits reveal a new class of hydrothermal system

Global analysis of fungal morphology exposes mechanisms of host cell escape

Pathways of allosteric regulation in Hsp70 chaperones

A universal self-charging system driven by random biomechanical energy for sustainable operation of mobile electronics

SiR–Hoechst is a far-red DNA stain for live-cell nanoscopy

Development of potent in vivo mutagenesis plasmids with broad mutational spectra

Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin

Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules

Incipient charge order observed by NMR in the normal state of YBa2Cu3Oy

Direct observation and imaging of a spin-wave soliton with p-like symmetry

Exometabolite niche partitioning among sympatric soil bacteria

Multi-cohort analysis of the maternal age effect on recombination

Subsistence strategies in traditional societies distinguish gut microbiomes

Ultrafast visualization of crystallization and grain growth in shock-compressed SiO2

Regional and global forcing of glacier retreat during the last deglaciation

Conformational states of the full-length glucagon receptor

Covalency of hydrogen bonds in liquid water can be probed by proton nuclear magnetic resonance experiments

Raman spectroscopy as probe of nanometre-scale strain variations in graphene

Evolution and emergence of infectious diseases in theoretical and real-world networks

Electronic Raman scattering as an ultra-sensitive probe of strain effects in semiconductors

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

External stimulation-controllable heat-storage ceramics

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

Conserved Omp85 lid-lock structure and substrate recognition in FhaC

Abundance of live 244Pu in deep-sea reservoirs on Earth points to rarityof actinide nucleosynthesis

Athermally photoreduced graphene oxides for three-dimensional holographic images

Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Imaging an aligned polyatomic molecule with laser-induced electron diffraction

Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis

CPI motif interaction is necessary for capping protein function in cells

Direct observation of liquid nucleus growth in homogeneous melting of colloidal crystals

Measurement of geometric dephasing using a superconducting qubit

Multi-scale thermal stability of a hard thermoplastic protein-based material

Demonstration of relativistic electron beam focusing by a laser-plasma lens

Galanin modulates the neural niche to favour perineural invasion in head and neck cancer

Piezo1 ion channel pore properties are dictated by C-terminal region

Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9

A novel liquid organic hydrogen carrier system based on catalytic peptide formation and hydrogenation

A molecular nematic liquid crystalline material for high-performance organic photovoltaics

Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation

Self-powered thin-film motion vector sensor

Single-molecule visualization of a formin-capping protein ‘decision complex' at the actin filament barbed end

Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling

Non-wetting surface-driven high-aspect-ratio crystalline grain growth for efficient hybrid perovskite solar cells

Defining the relationship between infection prevalence and clinical incidence of Plasmodium falciparum malaria

Digital quantum simulation of fermionic models with a superconducting circuit

Discovery of stable skyrmionic state in ferroelectric nanocomposites

Genetic pathways for differentiation of the peripheral nervous system in ascidians

Gut mucosal microbiome across stages of colorectal carcinogenesis

Basal forebrain control of wakefulness and cortical rhythms

Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase

Onset of two-dimensional superconductivity in space charge doped few-layer molybdenum disulfide

Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

Observation of non-Markovian micromechanical Brownian motion

Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation

Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus

Ontogeny of the maxilla in Neanderthals and their ancestors

High density terahertz frequency comb produced by coherent synchrotron radiation

Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila

Ionic transport in hybrid lead iodide perovskite solar cells

Erratum: A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration

Vimentin regulates activation of the NLRP3 inflammasome

How and when plume zonation appeared during the 132 Myr evolution of the Tristan Hotspot

Acute loss of TET function results in aggressive myeloid cancer in mice

High-resolution genetic mapping of maize pan-genome sequence anchors

Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling

X-ray photoemission analysis of clean and carbon monoxide-chemisorbed platinum(111) stepped surfaces using a curved crystal

Single-atom electron energy loss spectroscopy of light elements

Erratum: Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor

SUMOylation of TARBP2 regulates miRNA/siRNA efficiency

Ultimately short ballistic vertical graphene Josephson junctions

X-ray photonic microsystems for the manipulation of synchrotron light

Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan

A transposable element in a NAC gene is associated with drought tolerance in maize seedlings

Predicting oculomotor behaviour from correlated populations of posterior parietal neurons

Unique metabolites protect earthworms against plant polyphenols

Boron nitride colloidal solutions, ultralight aerogels and freestanding membranes through one-step exfoliation and functionalization

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

Entropy-stabilized oxides

Theta oscillations regulate the speed of locomotion via a hippocampus to lateral septum pathway

Characterizing noise structure in single-cell RNA-seq distinguishes genuine from technical stochastic allelic expression

Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility

A high-mobility electronic system at an electrolyte-gated oxide surface

Superconfinement tailors fluid flow at microscales

Uniform yolk-shell iron sulfide–carbon nanospheres for superior sodium–iron sulfide batteries

Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins

The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p

Designer diatom episomes delivered by bacterial conjugation

Experimental fault-tolerant universal quantum gates with solid-state spins under ambient conditions

Tunable solid-state fluorescent materials for supramolecular encryption

Mussel adhesion is dictated by time-regulated secretion and molecular conformation of mussel adhesive proteins

Fractionally charged skyrmions in fractional quantum Hall effect

FAAH genetic variation enhances fronto-amygdala function in mouse and human

High pressure effects revisited for the cuprate superconductor family with highest critical temperature

Role of redox centre in charge transport investigated by novel self-assembled conjugated polymer molecular junctions

Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signaling and protein synthesis

Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network

Enantiomeric switching of chiral metamaterial for terahertz polarization modulation employing vertically deformable MEMS spirals

High-quality EuO thin films the easy way via topotactic transformation

Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis

Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation

Neural dynamics of prediction and surprise in infants

Abnormal splicing switch of DMD's penultimate exon compromises muscle fibre maintenance in myotonic dystrophy

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

Brillouin-scattering-induced transparency and non-reciprocal light storage

Structural and dynamic insights into the energetics of activation loop rearrangement inFGFR1 kinase

A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus

Corrigendum: GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters

Modelling breast cancer requires identification and correction of a critical cell lineage-dependent transduction bias

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

Solubility design leading to high figure of merit in low-cost Ce-CoSb3 skutterudites

Spectromicroscopic insights for rational design of redox-based memristive devices

High-performing nonlinear visualization of terahertz radiation on a silicon charge-coupled device

Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells

Bright high-repetition-rate source of narrowband extreme-ultraviolet harmonics beyond 22 eV

Notch signal strength controls cell fate in the haemogenic endothelium

Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase

Photonic sensing of organic solvents through geometric study of dynamic reflection spectrum

Laboratory measurements of resistivity in warm dense plasmas relevant to the microphysics of brown dwarfs

Pie-like electrode design for high-energy density lithium–sulfur batteries

Dissecting the role of aberrant DNA methylation in human leukemia

Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells

Experimental evidence of new tetragonal polymorphs of silicon formed through ultrafast laser-induced confined microexplosion

Short winters threaten temperate fish populations

Integrating regional conservation priorities for multiple objectives into national policy

Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex

Symmetry breaking in drop bouncing on curved surfaces

Emergence of californium as the second transitional element in the actinide series

Controllable synthesis of molybdenum tungsten disulfide alloy for vertically composition-controlled multilayer

Creating semiconductor metafilms with designer absorption spectra

CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes

Extremely large magnetoresistance in few-layer graphene/boron–nitride heterostructures

Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization

Skilful multi-year predictions of tropical trans-basin climate variability

Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK

Large-scale climatic anomalies affect marine predator foraging behaviour and demography

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1

Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm–egg fusion in mice

An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products

Local atomic structure modulations activate metal oxide as electrocatalyst for hydrogen evolution in acidic water

Ultraviolet luminosity density of the universe during the epoch of reionization

Giant narrowband twin-beam generation along the pump-energy propagation direction

Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling

Spinal corollary discharge modulates motion sensing during vertebrate locomotion

Stabilization of 4H hexagonal phase in gold nanoribbons

Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data

Supramolecular block copolymers by kinetically controlled co-self-assembly of planar and core-twisted perylene bisimides

Microscale insights into pneumococcal antibiotic mutant selection windows

A highly reversible room-temperature lithium metal battery based on crosslinked hairy nanoparticles

Erratum: Lateral forces on circularly polarizable particles near a surface

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

Optical meta-atom for localization of light with quantized energy

Genome-wide burden of deleterious coding variants increased in schizophrenia

Highly indistinguishable photons from deterministic quantum-dot microlenses utilizing three-dimensional in situ electron-beam lithography

Self-assembled 2D WSe2 thin films for photoelectrochemical hydrogen production

Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

A palladium-catalysed multicomponent coupling approach to conjugated poly(1,3-dipoles) and polyheterocycles

Earth-like aqueous debris-flow activity on Mars at high orbital obliquity in the last million years

Inverted polymer fullerene solar cells exceeding 10% efficiency with poly(2-ethyl-2-oxazoline) nanodots on electron-collecting buffer layers

Corrigendum: NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma

Observation of a two-dimensional liquid of Fröhlich polarons at the bare SrTiO3 surface

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

Physical nanoscale conduit-mediated communication between tumour cells and the endothelium modulates endothelial phenotype

A two-dimensional algebraic quantum liquid produced by an atomic simulator of the quantum Lifshitz model

The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage

A new class of tunable hypersonic phononic crystals based on polymer-tethered colloids

TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution

The impact of disturbed peatlands on river outgassing in Southeast Asia

Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome

The evolution of spatial ordering of oil drops fast spreading on a water surface

Design of protein switches based on an ensemble model of allostery

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p

Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle

Graphitic carbon nitride nanosheet electrode-based high-performance ionic actuator

Fast and bright spontaneous emission of Er3+ ions in metallic nanocavity

Quantifying the density and utilization of active sites in non-precious metal oxygen electroreduction catalysts

Vasculopathy associated hyperangiotensinemia mobilizes hematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation

Temperature-triggered chemical switching growth of in-plane and vertically stacked graphene-boron nitride heterostructures

APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

The geometric phase controls ultracold chemistry

Sumoylation controls the timing of Tup1-mediated transcriptional deactivation

Structures of FolT in substrate-bound and substrate-released conformations reveal a gating mechanism for ECF transporters

Encapsulation of sulfur with thin-layered nickel-based hydroxides for long-cyclic lithium–sulfur cells

Loss of lamin A function increases chromatin dynamics in the nuclear interior

Quadratic Fermi node in a 3D strongly correlated semimetal

Atomic scale simulation of carbon nanotube nucleation from hydrocarbon precursors

Atlantic multi-decadal oscillation covaries with Agulhas leakage

Asymmetric synthesis of N-allylic indoles via regio- and enantioselective allylation of aryl hydrazines

Recoverable plasticity in penta-twinned metallic nanowires governed by dislocation nucleation and retraction

Chirality- and sequence-selective successive self-sorting via specific homo- and complementary-duplex formations

MEG3 long noncoding RNA regulates the TGF-β pathway genes throughformation of RNA–DNA triplex structures

EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques

Water desalination with a single-layer MoS2 nanopore

Optical focusing deep inside dynamic scattering media with near-infrared time-reversed ultrasonically encoded (TRUE) light

Strong correlations elucidate the electronic structure and phase diagram of LaAlO3/SrTiO3 interface

Nuclear envelope-associated endosomes deliver surface proteins to the nucleus

Determination of band alignment in the single-layer MoS2/WSe2 heterojunction

Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering

Planar carbon nanotube–graphene hybrid films for high-performance broadband photodetectors

Human gephyrin is encompassed within giant functional noncoding yin-yang sequences

Confocal multiview light-sheet microscopy

Rh D blood group conversion using transcription activator-like effector nucleases

Thermodynamic phase transitions in a frustrated magnetic metamaterial

Piezoresistivity in single DNA molecules

Transparent peer review at Nature Communications

Redistribution of Kv1 and Kv7 enhances neuronal excitability during structural axon initial segment plasticity

Constraints on soluble aerosol iron flux to the Southern Ocean at the Last Glacial Maximum

High-performance ternary blend polymer solar cells involving both energy transfer and hole relay processes

Transform-limited single photons from a single quantum dot

Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory

A chameleon-inspired stretchable electronic skin with interactive colour changing controlled by tactile sensing

Conserved nematode signalling molecules elicit plant defenses and pathogen resistance

Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus

Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia

Point nodes persisting far beyond T c in Bi2212

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

Rare coding variants and X-linked loci associated with age at menarche

Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios

Automated adaptive inference of phenomenological dynamical models

Upward synaptic scaling is dependent on neurotransmission rather than spiking

ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells

Sialic acid catabolism drives intestinal inflammation and microbial dysbiosis in mice

miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program

Dynamic designing of microstructures by chemical gradient-mediated growth

Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth

Phasing of single DNA molecules by massively parallel barcoding

Supramolecular motifs in dynamic covalent PEG-hemiaminal organogels

Evidence for a small hole pocket in the Fermi surface of underdoped YBa2Cu3O y

Coordination tuning of cobalt phosphates towards efficient water oxidation catalyst

Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex

Capacitance-modulated transistor detects odorant binding protein chiral interactions

Diverse mechanisms for spliceosome-mediated 3′ end processing of telomerase RNA

Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality

Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis

Unusually high soil nitrogen oxide emissions influence air quality in a high-temperature agricultural region

Targeting Bacteria via Iminoboronate Chemistry of Amine-Presenting Lipids

Transformation of the intestinal epithelium by the MSI2 RNA binding protein

Coordination and Fine Motor Control Depends on Drosophila TRPγ

Restoration of rhythmicity in diffusively coupled dynamical networks

An itinerant antiferromagnetic metal without magnetic constituents

Total synthesis of clostrubin

Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation

Reversed reactivity of anilines with alkynes in the rhodium-catalysed C–H activation/carbonylation tandem

MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease

Asymmetrically dividing Drosophila neuroblasts utilize two spatially and temporally independent cytokinesis pathways

Erratum: Topological data analysis of contagion maps for examining spreading processes on networks

Actin nucleation by WH2 domains at the autophagosome

Carbon–carbon bond activation of cyclobutenones enabled by the addition of chiral organocatalyst to ketone

Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila

Antimony-doped graphene nanoplatelets

Disinhibition of olfactory bulb granule cells accelerates odour discrimination in mice

Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci

Maxwell's demon in biochemical signal transduction with feedback loop

The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy

Cross-polarized photon-pair generation and bi-chromatically pumped optical parametric oscillation on a chip

Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B

Giant negative magnetoresistance induced by the chiral anomaly in individual Cd3As2 nanowires

Identification of candidate genes for prostate cancer-risk SNPs utilizing a normal prostate tissue eQTL data set

Large cooperativity and microkelvin cooling with a three-dimensional optomechanical cavity

Magnon dark modes and gradient memory

Chromatin De-Compaction By The Nucleosomal Binding Protein HMGN5 Impairs Nuclear Sturdiness

Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition

Anammox Planctomycetes have a peptidoglycan cell wall

Imaging regulatory T cell dynamics and suppression of T cell priming mediated by CTLA4

Crystalline silica-induced leukotrieneB4-dependent inflammation promotes lung tumor growth

Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear

Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis

Coordination templated [2+2+2] cyclotrimerization in a porous coordination framework

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

Histone H1-mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation

A biosynthetic model of cytochrome c oxidase as an electrocatalyst for oxygen reduction

Superdense teleportation using hyperentangled photons

A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma

Cytoplasmic TAF2–TAF8–TAF10 complex provides evidence for nuclear holo–TFIID assembly from preformed submodules

Demonstration of entanglement-enhanced phase estimation in solid

Measurement of the cleavage energy of graphite

Birth of two volcanic islands in the southern Red Sea

Site- and allele-specific polycomb dysregulation in T-cell leukaemia

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

An event-based architecture for solving constraint satisfaction problems

Degradation in carbon stocks near tropical forest edges

Role of T cell reconstitution in HIV-1 antiretroviral therapy-induced bone loss

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

Learning-related representational changes reveal dissociable integration and separation signatures in the hippocampus and prefrontal cortex

γ-secretase directly sheds the survival receptor BCMA from plasma cells

Longitudinal spin Seebeck effect contribution in transverse spin Seebeck effect experiments in Pt/YIG and Pt/NFO

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

The fatty acid elongase Bond is essential for Drosophila sex pheromone synthesis and male fertility

Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA

Impact of biodiversity loss on production in complex marine food webs mitigated by prey-release

A STIM2 splice variant negatively regulates store-operated calcium entry

Legionella suppresses the host unfolded protein response via multiple mechanisms

Cavity ring-up spectroscopy for ultrafast sensing with optical microresonators

Erratum: A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation

Conditional rotation of two strongly coupled semiconductor charge qubits

Cell shape dynamics during the staphylococcal cell cycle

Chamber identity programs drive early functional partitioning of the heart

Fractal dendrite-based electrically conductive composites for laser-scribed flexible circuits

Extreme ultraviolet imaging of three-dimensional magnetic reconnection in a solar eruption

Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

An actin-dependent spindle position checkpoint ensures the asymmetric division in mouse oocytes

Damage-tolerant nanotwinned metals with nanovoids under radiation environments

Plant species' origin predicts dominance and response to nutrient enrichment and herbivores in global grasslands

Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation

Multi-channel electronic and vibrational dynamics in polyatomic resonant high-order harmonic generation

Seismic monitoring in the oceans by autonomous floats

Loess Plateau storage of Northeastern Tibetan Plateau-derived Yellow River sediment

New loci and coding variants confer risk for age-related macular degeneration in East Asians

A quantitative model for charge carrier transport, trapping and recombination in nanocrystal-based solar cells

ChEC-seq kinetics discriminates transcription factor binding sites by DNA sequence and shape in vivo

Intestinal CD169+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes

Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation

DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1transcription factors in breast cancer progression

Quantum-secure covert communication on bosonic channels

Sperm navigation along helical paths in 3D chemoattractant landscapes

A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

Surface lattice resonances and magneto-optical response in magnetic nanoparticle arrays

The impact of climate change on photovoltaic power generation in Europe

Hyperdominance in Amazonian forest carbon cycling

The evolution of human and ape hand proportions

Nitric oxide mediates glial-induced neurodegeneration in Alexander disease

A low pre-infall mass for the Carina dwarf galaxy from disequilibrium modelling

Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells

Genomic and transcriptomic evidence for scavenging of diverse organic compounds by widespread deep-sea archaea

Rapid epitaxy-free graphene synthesis on silicidated polycrystalline platinum

NELL-1 in the treatment of osteoporotic bone loss

Ubiquity of Kelvin–Helmholtz waves at Earth's magnetopause

Erratum: Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity

Giant elastic tunability in strained BiFeO3 near an electrically induced phase transition

Directly measuring mean and variance of infinite-spectrum observables such as the photon orbital angular momentum

Reconfigurable photonic crystals enabled by pressure-responsive shape-memory polymers

TrkB/BDNF signalling patterns the sympathetic nervous system

Supramolecular-jack-like guest in ultramicroporous crystal for exceptional thermal expansion behaviour

Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway

Edge mixing dynamics in graphene p–n junctions in the quantum Hall regime

Impact of charge transport on current–voltage characteristics and power-conversion efficiency of organic solar cells

Analysis of immunoglobulin transcripts and hypermutation following SHIVAD8 infection and protein-plus-adjuvant immunization

Long-term decline in grassland productivity driven by increasing dryness

Metal-induced malformations in early Palaeozoic plankton are harbingers of mass extinction

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity

Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signaling

Structural basis for self-assembly of a cytolytic pore lined by protein and lipid

The DNA-binding network of Mycobacterium tuberculosi s

Climate constrains the evolutionary history and biodiversity of crocodylians

Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains

A diode for ferroelectric domain-wall motion

Adiabatic elimination-based coupling control in densely packed subwavelength waveguides

Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells

Two-dimensional single-cell patterning with one cell per well driven by surface acoustic waves

Ferroelectric domain wall motion induced by polarized light

A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

Origin and consequences of silicate glass passivation by surface layers

The SnRK2-APC/CTE regulatory module mediates the antagonistic action of gibberellic acid and abscisic acid pathways

Spectral splitting photovoltaics using perovskite and wideband dye-sensitized solar cells

A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs

The solar magnetic activity band interaction and instabilities that shape quasi-periodic variability

Ultrathin inorganic molecular nanowire based on polyoxometalates

Structurally driven one-dimensional electron confinement in sub-5-nm graphene nanowrinkles

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

dNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis

Atomic species identification at the (101) anatase surface by simultaneous scanning tunnelling and atomic force microscopy

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection

Probe-based measurement of lateral single-electron transfer between individual molecules

Selenium isotope evidence for progressive oxidation of the Neoproterozoic biosphere

Membranes with artificial free-volume for biofuel production

Photogated humidity-driven motility

ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy

The structure of FMNL2–Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation

A possible macronova in the late afterglow of the long–short burst GRB 060614

Electric-field-induced strong enhancement of electroluminescence in multilayer molybdenum disulfide

IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection

The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning

Kv3.1 uses a timely resurgent K+ current to secure action potential repolarization

Rational design of crystalline supermicroporous covalent organic frameworks with triangular topologies

Chirality transfer from gold nanocluster to adsorbate evidenced by vibrational circular dichroism

Measuring the mechanical properties of molecular conformers

Whole genome re-sequencing of date palms yields insights into diversification of a fruit tree crop

Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability

Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing

Enantiomer-specific analysis of multi-component mixtures by correlated electron imaging–ion mass spectrometry

Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa

Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway

Cavity optomechanics mediated by a quantum two-level system

Scaling up nanoscale water-driven energy conversion into evaporation-driven engines and generators

Dppa3 expression is critical for generation of fully reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting

Flexible lithium–oxygen battery based on a recoverable cathode

ATP hydrolysis assists phosphate release and promotes reaction ordering in F1-ATPase

Locking GTPases covalently in their functional states

Learning of anticipatory responses in single neurons of the human medial temporal lobe

Corrigendum: miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1–Lhx3

Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice

Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity

Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

Plasmonic cavity-apertures as dynamic pixels for the simultaneous control of colour and intensity

Distinguishing between plasmon-induced and photoexcited carriers in a device geometry

Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression

Long-life Li/polysulphide batteries with high sulphur loading enabled by lightweight three-dimensional nitrogen/sulphur-codoped graphene sponge

Uphill diffusion and overshooting in the adsorption of binary mixtures in nanoporous solids

Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function

Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress

Hail formation triggers rapid ash aggregation in volcanic plumes

SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling

PTEN regulates cilia through Dishevelled

Analysing black phosphorus transistors using an analytic Schottky barrier MOSFET model

How Leiomodin and Tropomodulin use a common fold for different actin assembly functions

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

Magnetic dipolar interaction between correlated triplets created by singlet fission in tetracene crystals

Abscisic acid transporters cooperate to control seed germination

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

Refining the Pathway of Carbide Insertion into the Nitrogenase M-cluster

Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas

Experimental demonstration of a non-resonant hyperlens in the visible spectral range

GITR subverts Foxp3+ Tregs to boost Th9 immunity through regulation of histone acetylation

Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

High-efficiency polymer solar cells with small photon energy loss

miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways

Non-autonomous DAF-16/FOXO activity antagonizes age-related loss of C. elegans germline stem/progenitor cells

Erratum: Low-threshold amplified spontaneous emission and lasing from colloidal nanocrystals of caesium lead halide perovskites

Projected phase-change memory devices

The genomics of ecological vicariance in threespine stickleback fish

Corrigendum: ChEC-seq kinetics discriminates transcription factor binding sites by DNA sequence and shape in vivo

Comprehensive survey of condition-specific reproductive isolation reveals genetic incompatibility in yeast

The limits of chemosensation vary across dimensions

Rapid biotic homogenization of marine fish assemblages

Appetitive floral odours prevent aggression in honeybees

Polarity-tunable magnetic tunnel junctions based on ferromagnetism at oxide heterointerfaces

Regulated Delivery of Molecular Cargo to Invasive Tumor-derived Microvesicles

Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma

Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode

Cosmochemical fractionation by collisional erosion during the Earth's accretion

Induced superconductivity in high-mobility two-dimensional electron gas in gallium arsenide heterostructures

Probing molecular dynamics at the nanoscale via an individual paramagnetic centre

Contrasting host–pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes

High-temperature water–rock interactions and hydrothermal environments in the chondrite-like core of Enceladus

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

Nanoscale assembly processes revealed in the nacroprismatic transition zone of Pinna nobilis mollusc shells

FTO influences adipogenesis by regulating mitotic clonal expansion

Enhanced light absorption by mixed source black and brown carbon particles in UK winter

Corrigendum: Dark-field X-ray microscopy for multiscale structural characterization

Enabling unassisted solar water splitting by iron oxide and silicon

Corrigendum: Freely orbiting magnetic tweezers to directly monitor changes in the twist of nucleic acids

Landscape simplification filters species traits and drives biotic homogenization

Design and synthesis of digitally encoded polymers that can be decoded and erased

Large-scale genomics unveil polygenic architecture of human cortical surface area

JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis

Variable Holocene deformation above a shallow subduction zone extremely close to the trench

Flexible coherent control of plasmonic spin-Hall effect

End-targeting proteomics of isolated chromatin segments of a mammalian ribosomal RNA gene promoter

Bloch-like waves in random-walk potentials based on supersymmetry

Towards a mechanistic understanding of carbon stabilization in manganese oxides

Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini

Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing

BMP signalling differentially regulates distinct haematopoietic stem cell types

Localization of Hippo signalling complexes and Warts activation in vivo

IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer

TCF12 is mutated in anaplastic oligodendroglioma

Ultrafast electronic state conversion at room temperature utilizing hidden state in cuprate ladder system

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Erratum: Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology

Reversibility and criticality in amorphous solids

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

Detection of entanglement in asymmetric quantum networks and multipartite quantum steering

Erratum: Coherence in the presence of absorption and heating in a molecule interferometer

Polyoxometalate-based homochiral metal-organic frameworks for tandem asymmetric transformation of cyclic carbonates from olefins

Scalable fabrication of a hybrid field-effect and acousto-electric device by direct growth of monolayer MoS2/LiNbO3

Covalency-reinforced oxygen evolution reaction catalyst

Corrigendum: OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria

Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma

The 40-residue insertion in Vibrio cholerae FadR facilitates binding of an additional fatty acyl-CoA ligand

Linker histone H1 and H3K56 acetylation are antagonistic regulators of nucleosome dynamics

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

Corrigendum: Annexin A2 promotes phagophore assembly by enhancing Atg16+ vesicle biogenesis and homotypic fusion

Influence of slip on the Plateau–Rayleigh instability on a fibre

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

A number-form area in the blind

Action plan co-optimization reveals the parallel encoding of competing reach movements

A redox signalling globin is essential for reproduction in Caenorhabditis elegans

Self-assembled hybrid metal oxide base catalysts prepared by simply mixing with organicmodifiers

Non-covalent synthesis of supermicelles with complex architectures using spatially confined hydrogen-bonding interactions

The microscopic structure of charge density waves in underdoped YBa2Cu3O6.54 revealed by X-ray diffraction

Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts

The development and characterization of synthetic minimal yeast promoters

Nanoscale surface chemistry directs the tunable assembly of silver octahedra into three two-dimensional plasmonic superlattices

Electronic cooling via interlayer Coulomb coupling in multilayer epitaxial graphene

Sub-10-fs population inversion in N2 + in air lasing through multiple state coupling

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer's disease pathology

Exponential self-replication enabled through a fibre elongation/breakage mechanism

Formin and capping protein together embrace the actin filament in a ménage à trois

Erratum: RTN1 mediates progression of kidney disease by inducing ER stress

A piRNA-like small RNA interacts with and modulates p-ERM proteins in human somatic cells

Ultrasensitive visual read-out of nucleic acids using electrocatalytic fluid displacement

Identification of phases, symmetries and defects through local crystallography

Three-fold rotational defects in two-dimensional transition metal dichalcogenides

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis

Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease

Control of cytoplasmic dynein force production and processivity by its C-terminal domain

RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection

The free energy of mechanically unstable phases

Edge-terminated molybdenum disulfide with a 9.4-Å interlayer spacing for electrochemical hydrogen production

Combinatorial code governing cellular responses to complex stimuli

New insights into photoactivated volume generation boost surface morphing in liquid crystal coatings

Strain-induced metal–semiconductor transition observed in atomic carbon chains

Kinetics and fracture resistance of lithiated silicon nanostructure pairs controlled by their mechanical interaction

Non-random patterns in viral diversity

Description of quantum coherence in thermodynamic processes requires constraints beyond free energy

High-speed multiple-mode mass-sensing resolves dynamic nanoscale mass distributions

Low-threshold amplified spontaneous emission and lasing from colloidal nanocrystals of caesium lead halide perovskites

miR-218 is Essential to Establish Motor Neuron Fate as a Downstream Effector of Isl1-Lhx3

Ferromagnetism induced by entangled charge and orbital orderings in ferroelectric titanate perovskites

Experimental observation of N00N state Bloch oscillations

Initial assembly steps of a translocase for folded proteins

Accelerated sintering in phase-separating nanostructured alloys

An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency

Memory programming in CD8+ T-cell differentiation is intrinsic and is not determined by CD4 help

Evidence of covalent synergy in silicon–sulfur–graphene yielding highly efficient and long-life lithium-ion batteries

The photochemical mechanism of a B12-dependent photoreceptor protein

In silico prediction and screening of modular crystal structures via a high-throughput genomic approach

Evidence for an oxygen evolving iron–oxo–cerium intermediate in iron-catalysed water oxidation

Enhancer repertoires are reshaped independently of early priming and heterochromatin dynamics during B cell differentiation

Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals

Aversive learning shapes neuronal orientation tuning in human visual cortex

Tectonic control on the persistence of glacially sculpted topography

Neural Organization of Spoken Language Revealed by Lesion-Symptom Mapping

Brightness-equalized quantum dots

Hypothalamic PKA regulates leptin sensitivity and adiposity

Positioning and joining of organic single-crystalline wires

Highly specific in vivo gene delivery for p53-mediated apoptosis and genetic photodynamic therapies of tumour

Ambipolar solution-processed hybrid perovskite phototransistors

Corrigendum: Protruding knob-like proteins violate local symmetries in an icosahedral marine virus

Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model

Large-scale spatiotemporal spike patterning consistent with wave propagation in motor cortex

Nanoscale origins of the damage tolerance of the high-entropy alloy CrMnFeCoNi

Thermodynamic picture of ultrafast charge transport in graphene

Ultrahigh volumetric capacitance and cyclic stability of fluorine and nitrogen co-doped carbon microspheres

Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-Å resolution

Climate-induced variations in global wildfire danger from 1979 to 2013

POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation

Corrigendum: Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response

Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity

Dynamical origin of near- and below-threshold harmonic generation of Cs in an intense mid-infrared laser field

The structural origin of the hard-sphere glass transition in granular packing

Skp2-MacroH2A1-CDK8 axis orchestrates G2/M transition, polyploidy and tumourigenesis

Yak whole-genome resequencing reveals domestication signatures and prehistoric population expansions

MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas

A role for E-cadherin in ensuring cohesive migration of a heterogeneous population of non-epithelial cells

Adaptive immunity increases the pace and predictability of evolutionary change in commensal gut bacteria

Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck

Interplay of weak interactions in the atom-by-atom condensation of xenon within quantum boxes

Late Na+ current and protracted electrical recovery are critical determinants of the aging myopathy

Single-site trinuclear copper oxygen clusters in mordenite for selective conversion of methane to methanol

Polarization-independent actively tunable colour generation on imprinted plasmonic surfaces

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain

Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes

Structural permeability of complex networks to control signals

An intrinsic timer specifies distal structures of the vertebrate limb

The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NFκB activation

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy

Subcontinuum mass transport of condensed hydrocarbons in nanoporous media

An acetylation switch controls TDP-43 function and aggregation propensity

The Lin28/let-7 axis is critical for myelination in the peripheral nervous system

Subglacial lake drainage detected beneath the Greenland ice sheet

TRPM8 is a neuronal osmosensor that regulates eye blinking in mice

Liquid exfoliation of solvent-stabilized few-layer black phosphorus for applications beyond electronics

Maturation of the HIV-1 core by a non-diffusional phase transition

LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation

Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci

PAM multiplicity marks genomic target sites as inhibitory to CRISPR-Cas9 editing

Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes

A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals

Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS–PKS hybrid enzyme

NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine

Harnessing the landscape of microbial culture media to predict new organism–media pairings

Rescue of long-term memory after reconsolidation blockade

Patterning two-dimensional chalcogenide crystals of Bi2Se3 and In2Se3 and efficient photodetectors

High-resolution vector microwave magnetometry based on solid-state spins in diamond

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

Drivers of the US CO2 emissions 1997–2013

Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin

Ternary metal fluorides as high-energy cathodes with low cycling hysteresis

Corrigendum: PICALM modulates autophagy activity and tau accumulation

Inward lithium-ion breathing of hierarchically porous silicon anodes

AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation

Observations of discrete harmonics emerging from equatorial noise

Boundaries for martensitic transition of 7Li under pressure

Obliquity pacing of the western Pacific Intertropical Convergence Zone over the past 282,000 years

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

Ultrafast response of monolayer molybdenum disulfide photodetectors

Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy

NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production

Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Annexin A2 promotes phagophore assembly by enhancing Atg16L+ vesicle biogenesis and homotypic fusion

Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions

The solvation of electrons by an atmospheric-pressure plasma

Interlayer orientation-dependent light absorption and emission in monolayer semiconductor stacks

Lower glycolysis carries a higher flux than any biochemically possible alternative

High damage tolerance of electrochemically lithiated silicon

Residue-specific structures and membrane locations of pH-low insertion peptide by solid-state nuclear magnetic resonance

Opposite correlations between cation disordering and amorphization resistance in spinels versus pyrochlores

Wafer-scale growth of VO2 thin films using a combinatorial approach

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition

Micromotors with asymmetric shape that efficiently convert light into work by thermocapillary effects

Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling

Caenorhabditis elegans is a useful model for anthelmintic discovery

Membrane tension and peripheral protein density mediate membrane shape transitions

Quorum sensing triggers the stochastic escape of individual cells from Pseudomonas putida biofilms

Pseudocapacitance of MXene nanosheets for high-power sodium-ion hybrid capacitors

Lucilia cuprina genome unlocks parasitic fly biology to underpin future interventions

Efficient water reduction with gallium phosphide nanowires

Crystallization seeds favour crystallization only during initial growth

Combining Spinach-tagged RNA and gene localization to image gene expression in live yeast

Regulation of Nucleotide Metabolism by Mutant p53 Contributes to its Gain-of-Function Activities

LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesis

Controlling band alignments by artificial interface dipoles at perovskite heterointerfaces

Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR–eIF4F pathway

Transformable liquid-metal nanomedicine

Scalable, full-colour and controllable chromotropic plasmonic printing

Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue

Flow damping due to stochastization of the magnetic field

Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179

Partially coherent ultrafast spectrography

Designing bioinspired composite reinforcement architectures via 3D magnetic printing

Electrical probing of field-driven cascading quantized transitions of skyrmion cluster states in MnSi nanowires

Simultaneous observation of the quantization and the interference pattern of a plasmonic near-field

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

A flexible codon in genomically recoded Escherichia coli permits programmable protein phosphorylation

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

Dynamic caveolae exclude bulk membrane proteins and are required for sorting of excess glycosphingolipids

Numerical chromosomal instability mediates susceptibility to radiation treatment

Active suppression of intestinal CD4+TCRαβ+ T-lymphocyte maturation during the postnatal period

Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells

Thickness dependence of the interfacial Dzyaloshinskii–Moriya interaction in inversion symmetry broken systems

Controlling dispersion forces between small particles with artificially created random light fields

Cobalt-catalysed site-selective intra- and intermolecular dehydrogenative amination of unactivated sp3 carbons

Lateral forces on circularly polarizable particles near a surface

Evolution and control of the phase competition morphology in a manganite film

Trainable hardware for dynamical computing using error backpropagation through physical media

Activation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

Spatiotemporal noise characterization for chirped-pulse amplification systems

EphrinB2 controls vessel pruning through STAT1-JNK3 signaling

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

The transcriptional landscape of age in human peripheral blood

Suppressed phase transition and giant ionic conductivity in La2Mo2O9 nanowires

Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses

Control of switching between metastable superconducting states in δ-MoN nanowires

Developmental disruptions underlying brain abnormalities in ciliopathies

Dynamic acousto-optic control of a strongly coupled photonic molecule

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers

Influencing the properties of dysprosium single-molecule magnets with phosphorus donor ligands

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis

Loss of KLF14 triggers centrosome amplification and tumorigenesis

Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution

Tissue landscape alters adjacent cell fates during Drosophila egg development

Encoding and decoding spatio-temporal information for super-resolution microscopy

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

Asymmetric ring structure of Vps4 required for ESCRT-III disassembly

Photoelectric detection of electron spin resonance of nitrogen-vacancy centres in diamond

A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses

Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells

Assembling an alkyl rotor to access abrupt and reversible crystalline deformation of a cobalt(II) complex

Wave-driven butterfly distribution of Van Allen belt relativistic electrons

PRMT9 is a Type II methyltransferase that methylates the splicing factor SAP145

Structural characterization of a protective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomers

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

The phase diagram of high-pressure superionic ice

Extreme multifunctional proteins identified from a human protein interaction network

A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion

Band structure engineering via piezoelectric fields in strained anisotropic CdSe/CdS nanocrystals

Carrier separation and transport in perovskite solar cells studied by nanometre-scale profiling of electrical potential

A new class of chiral materials hosting magnetic skyrmions beyond room temperature

The first archaic Homo from Taiwan

Implementation of continuous-variable quantum key distribution with composable and one-sided-device-independent security against coherent attacks

Mechanically selflocked chiral gemini-catenanes

Quantum Hall states stabilized in semi-magnetic bilayers of topological insulators

Telomeric G-quadruplexes are a substrate and site of localization for humantelomerase

Genetic structure characterization of Chileans reflects historical immigration patterns

An IL-27/NFIL3 signaling axis drives Tim-3 and IL-10 expression and T cell dysfunction

Fat, Fiber and Cancer Risk in African Americans and Rural Africans

PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation

Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor

Observation of optical solitons in PT-symmetric lattices

IRSp53 senses negative membrane curvature and phase separates along membrane tubules

Atomic description of the immune complex involved in heparin-induced thrombocytopenia

Quantum simulation of 2D topological physics in a 1D array of optical cavities

Steady-state cross-correlations for live two-colour super-resolution localization data sets

Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast

Large-scale models of signal propagation in human cells derived from discovery phosphoproteomic data

Trehalose Glycopolymer Resists Allow Direct Writing of Protein Patterns by Electron-Beam Lithography

Loss of kinesin-14 results in aneuploidy via kinesin-5-dependent microtubule protrusions leading to chromosome cut

Flexible suspended gate organic thin-film transistors for ultra-sensitive pressure detection

Three-dimensional nanometre localization of nanoparticles to enhance super-resolution microscopy

Experimental Evidence for the Co-Evolution of Hominin Tool-Making Teaching and Language

Nanophotonic coherent light–matter interfaces based on rare-earth-doped crystals

Facile synthesis of ultrahigh-surface-area hollow carbon nanospheres for enhanced adsorption and energy storage

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

Visualizing nanoscale 3D compositional fluctuation of lithium in advanced lithium-ion battery cathodes

Structured line illumination Raman microscopy

An in situ self-assembly template strategy for the preparation of hierarchical-pore metal-organic frameworks

Cooper pair splitting in parallel quantum dot Josephson junctions

An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding

Signature of magnetic-dependent gapless odd frequency states at superconductor/ferromagnet interfaces

Strain induced fragility transition in metallic glass

Evidence for holistic episodic recollection via hippocampal pattern completion

Atomic cobalt on nitrogen-doped graphene for hydrogen generation

EphB4 forward signalling regulates lymphatic valve development

Corrigendum: Circadian control of bile acid synthesis by a KLF15-Fgf15 axis

Humidity trends imply increased sensitivity to clouds in a warming Arctic

Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC

Modulating protein activity using tethered ligands with mutually exclusive binding sites

miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement

Different forms of effective connectivity in primate frontotemporal pathways

Rapid sequestration of rock avalanche deposits within glaciers

De novo assembly and next-generation sequencing to analyse full-length gene variants from codon-barcoded libraries

Radical cascade reaction of alkynes with N-fluoroarylsulfonimides and alcohols

Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled

Probing three-dimensional sodiation–desodiation equilibrium in sodium-ion batteries by in situ hard X-ray nanotomography

Suppression of nuclear spin bath fluctuations in self-assembled quantum dots induced by inhomogeneous strain

Probing deformed commutators with macroscopic harmonic oscillators

Extremely durable biofouling-resistant metallic surfaces based on electrodeposited nanoporous tungstite films on steel

Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis

Visualizing the non-equilibrium dynamics of photoinduced intramolecular electron transfer with femtosecond X-ray pulses

Sustainability and dynamics of outcrop-to-outcrop hydrothermal circulation

Context influences on TALE–DNA binding revealed by quantitative profiling

Structural analyses of the chromatin remodeling enzymes INO80-C and SWR-C

Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence

Extremely stretchable and conductive water-repellent coatings for low-cost ultra-flexible electronics

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing

A novel thiol-reductase activity of Arabidopsis YUC6 confers drought tolerance independently of auxin biosynthesis

Epigenomic footprints across 111 reference epigenomes reveal tissue-specific epigenetic regulation of lincRNAs

Nitrogenated holey two-dimensional structures

Erratum: Structural isomerism in gold nanoparticles revealed by X-ray crystallography

Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer

Integration of photonic nanojets and semiconductor nanoparticles for enhanced all-optical switching

Optical aperture synthesis with electronically connected telescopes

Spatiotemporal isolation of attosecond soft X-ray pulses in the water window

Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes

Efficient expression of full-length antibodies in the cytoplasm of engineered bacteria

Critical Role of Sphingosine-1-Phosphate Receptor-2 in the Disruption of Cerebrovascular Integrity in Experimental Stroke

Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma

Multiradionuclide evidence for the solar origin of the cosmic-ray events of ᴀᴅ 774/5 and 993/4

Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane

Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody

Infection-induced type I interferons activate CD11b on B-1 cells for subsequent lymph node accumulation

SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment

Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity

Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety

Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling

Identification of four new susceptibility loci for testicular germ cell tumour

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells

An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment

Superconductivity emerging from a suppressed large magnetoresistant state in tungsten ditelluride

MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response

Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals

Amygdala lesions in rhesus macaques decrease attention to threat

Quantum engineering of spin and anisotropy in magnetic molecular junctions

Genetic interactions contribute less than additive effects to quantitative trait variation in yeast

Central and rear-edge populations can be equally vulnerable to warming

Experimental quantum fingerprinting with weak coherent pulses

Optimal speed estimation in natural image movies predicts human performance

Orbitofrontal lesions eliminate signaling of biological significance in cue-responsive ventral striatal neurons

The evolutionary landscape of intergenic trans-splicing events in insects

Multipole plasmons and their disappearance in few-nanometre silver nanoparticles

Increased reservoir ages and poorly ventilated deep waters inferred in the glacial Eastern Equatorial Pacific

Imaging screw dislocations at atomic resolution by aberration-corrected electron optical sectioning

Recent decrease in typhoon destructive potential and global warming implications

Crystallization of DNA-coated colloids

Photon number statistics uncover the fluctuations in non-equilibrium lattice dynamics

Navigable networks as Nash equilibria of navigation games

Non-redundant Requirement for CXCR3 Signaling during Tumoricidal T Cell Trafficking across Tumor Vascular Checkpoints

Robust self-cleaning and micromanipulation capabilities of gecko spatulae and their bio-mimics

Metallic glass nanostructures of tunable shape and composition

Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia

Platelet actin nodules are podosome-like structures dependent on Wiskott–Aldrich syndrome protein and ARP2/3 complex

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

Crystal preferred orientation of an amphibole experimentally deformed by simple shear

A biomimetic hybrid nanoplatform for encapsulation and precisely controlled delivery of therasnostic agents

Alternative futures for Borneo show the value of integrating economic and conservation targets across borders

Specificity and catalysis hardwired at the RNA–protein interface in a translational proofreading enzyme

Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria

Gate-controlled generation of optical pulse trains using individual carbon nanotubes

Paracingulate sulcus morphology is associated with hallucinations in the human brain

Ultrafast optical modification of exchange interactions in iron oxides

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway

Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis

Evolution of dosage compensation under sexual selection differs between X and Z chromosomes

Superconductivity-induced re-entrance of the orthorhombic distortion in Ba1−x K x Fe2As2

Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration

Declining resilience of ecosystem functions under biodiversity loss

Transformation and patterning of supermicelles using dynamic holographic assembly

Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain

Dip-pen patterning of poly(9,9-dioctylfluorene) chain-conformation-based nano-photonic elements

The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs

Erratum: miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development

Spin-dependent recombination probed through the dielectric polarizability

Self-assembly of dynamic orthoester cryptates

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates

Direct visualization of dispersed lipid bicontinuous cubic phases by cryo-electron tomography

Atomic basis for therapeutic activation of neuronal potassium channels

Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice

A quantitative description of Ndc80 complex linkage to human kinetochores

Carbon-doped BN nanosheets for metal-free photoredox catalysis

Escape from crossover interference increases with maternal age

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

High-performance n-type black phosphorus transistors with type control via thickness and contact-metal engineering

Universal structure of transmission eigenchannels inside opaque media

An insula-frontostriatal network mediates flexible cognitive control by adaptively predicting changing control demands

MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex

A Metabolic Stress-inducible miR-34a-HNF4α Pathway Regulates Lipid and Lipoprotein Metabolism

Dual role for ubiquitin in plant steroid hormone receptor endocytosis

Terahertz-driven linear electron acceleration

BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5

Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography

A post-transcriptional mechanism pacing expression of neural genes with precursor cell differentiation status

A new tool called DISSECT for analysing large genomic data sets using a Big Data approach

Inside-out Ca2+ signalling prompted by STIM1 conformational switch

The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia

Structural insights into the translational infidelity mechanism

Light-induced crawling of crystals on a glass surface

Ultra-high modulation depth exceeding 2,400% in optically controlled topological surface plasmons

Nanoscale size effects in crystallization of metallic glass nanorods

The full repertoire of Drosophila gustatory receptors for detecting an aversive compound

Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure

Limited role of functional differentiation in early diversification of animals

Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain

Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα

Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning

Topologically protected surface states in a centrosymmetric superconductor β-PdBi2

Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded light

Genome-wide Identification of microRNA Expression Quantitative Trait Loci

Single-trial dynamics of motor cortex and their applications to brain-machine interfaces

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis

Trained immunity in newborn infants of HBV-infected mothers

Two-photon fluorescence lifetime imaging of primed SNARE complexes in presynaptic terminals and β cells

MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours

Genome-wide association study identifies multiple susceptibility loci for glioma

Cationic mononuclear ruthenium carboxylates as catalyst prototypes for self-induced hydrogenation of carboxylic acids

Endothelial Gata5 transcription factor regulates blood pressure

A plasmonic nanorod that walks on DNA origami

Single-band upconversion nanoprobes for multiplexed simultaneous in situ molecular mapping of cancer biomarkers

Sorting of small infectious virus particles by flow virometry reveals distinct infectivity profiles

Flexible transition metal dichalcogenide nanosheets for band-selective photodetection

Universal mechanisms of sound production and control in birds and mammals

Synthesis of quasi-free-standing bilayer graphene nanoribbons on SiC surfaces

Porous molybdenum carbide nano-octahedrons synthesized via confined carburization in metal-organic frameworks for efficient hydrogen production

Multitrophic diversity in a biodiverse forest is highly nonlinear across spatial scales

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor

Dynamically stabilized magnetic skyrmions

Real-time intermembrane force measurements and imaging of lipid domain morphology during hemifusion

Local and bulk 13C hyperpolarization in nitrogen-vacancy-centred diamonds at variable fields and orientations

Nanoscale imaging of buried topological defects with quantitative X-ray magnetic microscopy

High-resolution analysis of the human T-cell receptor repertoire

Circadian control of bile acid synthesis by a KLF15-Fgf15 axis

Elucidating the role of disorder and free-carrier recombination kinetics in CH3NH3PbI3 perovskite films

Unexpected edge conduction in mercury telluride quantum wells under broken time-reversal symmetry

Prevalent and distinct spliceosomal 3′-end processing mechanisms for fungal telomerase RNA

Subcycle-resolved probe retardation in strong-field pumped dielectrics

Electrochemical synthesis of mesoporous gold films toward mesospace-stimulated optical properties

Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length

Gut microbiota mediate caffeine detoxification in the primary insect pest of coffee

Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association

A sublimation heat engine

Control of developmentally primed erythroid genes by combinatorial co-repressor actions

Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy

Origins of multicellular evolvability in snowflake yeast

Active porous transition towards spatiotemporal control of molecular flow in a crystal membrane

p75NTR-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte–endothelial crosstalk in diabetes after limb ischaemia

The dynamics of methylammonium ions in hybrid organic–inorganic perovskite solar cells

Noble metal-comparable SERS enhancement from semiconducting metal oxides by making oxygen vacancies

PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine

The Matricellular Protein CCN1 Mediates Neutrophil Efferocytosis in Cutaneous Wound Healing

Two-dimensional magnetotransport in a black phosphorus naked quantum well

Sub-phonon-period compression of electron pulses for atomic diffraction

Quantifying the stabilizing effects of protein–ligand interactions in the gas phase

A strong-field driver in the single-cycle regime based on self-compression in a kagome fibre

Optoelectronic crystal of artificial atoms in strain-textured molybdenum disulphide

A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness

Laser chimeras as a paradigm for multistable patterns in complex systems

Macroscopic ordering of helical pores for arraying guest molecules noncentrosymmetrically

A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease

Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1

Settling time of a vibrational wavepacket in ionization

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex

Observation of vibrational overtones by single-molecule resonant photodissociation

Light generation of intracellular Ca2+ signals by a genetically encoded protein BACCS

Allele-specific analysis of DNA replication origins in mammalian cells

Crystalline CO2-based polycarbonates prepared from racemic catalyst through intramolecularly interlocked assembly

Absorption-induced scattering and surface plasmon out-coupling from absorber-coated plasmonic metasurfaces

Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy

Cerebral complexity preceded enlarged brain size and reduced olfactory bulbs in Old World monkeys

Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses

A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy

Gap geometry dictates epithelial closure efficiency

Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development

Common and rare variants associated with kidney stones and biochemical traits

Activation and lysis of human CD4 cells latently infected with HIV-1

Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle

Multimaterial magnetically assisted 3D printing of composite materials

Rethinking fast and slow based on a critique of reaction-time reverse inference

Atomic-like spin noise in solid-state demonstrated with manganese in cadmium telluride

DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice

Single-shot spectro-temporal characterization of XUV pulses from a seeded free-electron laser

Transcriptional elongation requires DNA break-induced signalling

In situ oxidation of carbon-encapsulated cobalt nanocapsules creates highly active cobalt oxide catalysts for hydrocarbon combustion

Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation

Slow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage

Coordinating activation strategy for C(sp 3)–H/C(sp 3)–H cross-coupling to access β-aromatic α-amino acids

Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes

Large Seebeck effect by charge-mobility engineering

Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci

Magnetic anisotropy in Shiba bound states across a quantum phase transition

Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography

Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting

Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1

Prmt5 is a regulator of muscle stem cell expansion in adult mice

A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D confinement

Logging cuts the functional importance of invertebrates in tropical rainforest

Intermediate DNA methylation is a conserved signature of genome regulation

The molecular architecture of the Dam1 kinetochore complex is defined by cross-linking based structural modelling

Realizing high figure of merit in heavy-band p-type half-Heusler thermoelectric materials

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

The genetic basis of natural variation in mushroom body size in Drosophila melanogaster

Two-dimensional gold nanostructures with high activity for selective oxidation of carbon–hydrogen bonds

The propagation of perturbations in rewired bacterial gene networks

Erratum: Different forms of effective connectivity in primate frontotemporal pathways

Enhanced wetting of Cu on ZnO by migration of subsurface oxygen vacancies

Emerging magnetic order in platinum atomic contacts and chains

RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1

Embryonic transcription is controlled by maternally defined chromatin state

The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication

Genetic similarity between cancers and comorbid Mendelian diseases identifies candidate driver genes

Targeting of SUMO substrates to a Cdc48–Ufd1–Npl4 segregase and STUbL pathway in fission yeast

Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst

Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy

High charge mobility in two-dimensional percolative networks of PbSe quantum dots connected by atomic bonds

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Adhesive curing through low-voltage activation

NR2F1 controls tumor cell dormancy via SOX9 and RARβ driven quiescence programs

Erratum: Cooper pair splitting in parallel quantum dot Josephson junctions

Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain

Supramolecular synergy in the boundary lubrication of synovial joints

STED nanoscopy with fluorescent quantum dots

D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2

Correction of F508del CFTR in airway epithelium using nanoparticles delivering triplex-forming PNAs

Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism

Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method

A highly conspicuous mineralized composite photonic architecture in the translucent shell of the blue-rayed limpet

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core

Auditory sequence processing reveals evolutionarily conserved regions of frontal cortex in macaques and humans

Coherence in the presence of absorption and heating in a molecule interferometer

Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism

Ultrastructural and functional fate of recycled vesicles in hippocampal synapses

Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes

Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis

PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation

Chromatin organization at the nuclear pore favours HIV replication

Signal-sequence induced conformational changes in the signal recognition particle

Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs

Compensating for population sampling in simulations of epidemic spread on temporal contact networks

Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome

Upward electrical discharges observed above Tropical Depression Dorian

The thiostrepton A tryptophan methyltransferase TsrM catalyses a cob(II)alamin-dependent methyl transfer reaction

Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins

Embryo-scale tissue mechanics during Drosophila gastrulation movements

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1–BAP1 complex

Biological interpretation of genome-wide association studies using predicted gene functions

Multiple-length-scale deformation analysis in a thermoplastic polyurethane

All-passive nonreciprocal metastructure

Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus

RNA structure determination by solid-state NMR spectroscopy

High-performance green flexible electronics based on biodegradable cellulose nanofibril paper

Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies

A porous metal-organic framework with ultrahigh acetylene uptake capacity under ambient conditions

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence

Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis

Detoxification of hostplant's chemical defence rather than its anti-predator co-option drives β-glucosidase-mediated lepidopteran counteradaptation

Vibronic origin of long-lived coherence in an artificial molecular light harvester

Electrodeposition of hierarchically structured three-dimensional nickel–iron electrodes for efficient oxygen evolution at high current densities

Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action

Valley polarization assisted spin polarization in two dimensions

Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling

Bivalent separation into univalents precedes age-related meiosis I errors in oocytes

Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies

Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

Improving image contrast and material discrimination with nonlinear response in bimodal atomic force microscopy

Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

Local destruction of superconductivity by non-magnetic impurities in mesoscopic iron-based superconductors

An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis

Expression of heterologous sigma factors enables functional screening of metagenomic and heterologous genomic libraries

EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma

Quantum-enabled temporal and spectral mode conversion of microwave signals

MRI detection of breast cancer micrometastases with a fibronectin-targeting contrast agent

Observation of laser-induced electronic structure in oriented polyatomic molecules

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

Moisture dipole over the Tibetan Plateau during the past five and a half centuries

Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint

Discovery of protein acetylation patterns by deconvolution of peptide isomer mass spectra

Nanoscale optical positioning of single quantum dots for bright and pure single-photon emission

Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts

S-nitrosylation triggers ABI5 degradation to promote seed germination and seedling growth

Structure and dynamics of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA

A recursive vesicle-based model protocell with a primitive model cell cycle

The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle

Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch

Interactions between horizontally acquired genes create a fitness cost in Pseudomonas aeruginosa

Symmetry-protected transport in a pseudospin-polarized waveguide

Satisfying the Einstein–Podolsky–Rosen criterion with massive particles

Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones

Regulation of systemic energy homeostasis by serotonin in adipose tissues

Multi-localization transport behaviour in bulk thermoelectric materials

Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors

Correlated compositional and mineralogical investigations at the Chang′e-3 landing site

Acidic phospholipids govern the enhanced activation of IgG-B cell receptor

Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice

Scalable amplification of strand subsets from chip-synthesized oligonucleotide libraries

Real-time submillisecond single-molecule FRET dynamics of freely diffusing molecules with liposome tethering

Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2

The deuterium/hydrogen distribution in chondritic organic matter attests to early ionizing irradiation

Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex

Abiotic ligation of DNA oligomers templated by their liquid crystal ordering

Deterministic processes vary during community assembly for ecologically dissimilar taxa

Droplets move over viscoelastic substrates by surfing a ridge

Photoswitchable fatty acids enable optical control of TRPV1

Optodynamic simulation of β-adrenergic receptor signalling

A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells

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Direct terrestrial test of Lorentz symmetry in electrodynamics to 10−18

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Making water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy

New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues

Connecting the oxidation of soot to its redox cycling abilities

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AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease

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Total synthesis of (+)-gelsemine via an organocatalytic Diels–Alder approach

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Ocean acidification increases the accumulation of toxic phenolic compounds across trophic levels

Trans-mitochondrial coordination of cristae at regulated membrane junctions

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

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Atomically thin resonant tunnel diodes built from synthetic van der Waals heterostructures

Structure and substrate selectivity of the 750-kDa α6β6 holoenzyme of geranyl-CoA carboxylase

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

Highly compressible 3D periodic graphene aerogel microlattices

Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores

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Farnesoid X Receptor Inhibits Glucagon-Like Peptide-1 Production by Enteroendocrine L-cells

Content Provider	PubMed Central
Author	Trabelsi, Mohamed-sami Daoudi, Mehdi Prawitt, Janne Ducastel, Sarah Touche, Véronique Sayin, Sama I. Perino, Alessia Brighton, Cheryl A. Sebti, Yasmine Kluza, Jérôme Briand, Olivier Dehondt, Hélène Vallez, Emmanuelle Emilie, Dorchies Baud, Grégory Spinelli, Valeria Hennuyer, Nathalie Caron, Sandrine Bantubungi, Kadiombo Caiazzo, Robert Reimann, Frank Marchetti, Philippe Lefebvre, Philippe BÄckhed, Fredrik Gribble, Fiona M. Schoonjans, Kristina Pattou, François Anne, Tailleux Bart, Staels Sophie, Lestavel
Abstract	Bile acids (BA) are signalling molecules which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex BA in the intestinal lumen and decrease intestinal FXR activity. The BAS-BA complex also induces Glucagon-Like Peptide-1 (GLP-1) production by L-cells which potentiates β-cell glucose-induced insulin secretion. Whether FXR is expressed in L-cells and controls GLP-1 production is unknown. Here we show that FXR activation in L-cells decreases proglucagon expression by interfering with the glucose-responsive factor Carbohydrate-Responsive Element Binding Protein (ChREBP) and GLP-1 secretion by inhibiting glycolysis. In vivo, FXR-deficiency increases GLP-1 gene expression and secretion in response to glucose hence improving glucose metabolism. Moreover, treatment of ob/ob mice with the BAS colesevelam increases intestinal proglucagon gene expression and improves glycemia in a FXR-dependent manner. These findings identify the FXR/GLP-1 pathway as a new mechanism of BA control of glucose metabolism and a pharmacological target for type 2 diabetes.
Related Links	http://dx.doi.org/10.1038/ncomms8629
Starting Page	7629
File Format	PDF
ISSN	20411723
e-ISSN	20411723
Journal	Nature communications
Volume Number	6
Language	English
Publisher Date	2015-07-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) Chemistry(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Physics and Astronomy Biochemistry, Genetics and Molecular Biology

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