NDLI: The key role of the scaffold on the efficiency of dendrimer nanodrugs

Content Provider	PubMed Central
Author	Caminade, Anne-marie Fruchon, Séverine Turrin, Cédric-olivier Mary, Poupot Ouali, Armelle Maraval, Alexandrine Garzoni, Matteo Maly, Marek Furer, Victor Kovalenko, Valeri Majoral, Jean-pierre Pavan, Giovanni M. Rémy, Poupot
Copyright Year	2015
Abstract	Dendrimers are well-defined macromolecules whose highly branched structure is reminiscent of many natural structures, such as trees, dendritic cells, neurons or the networks of kidneys and lungs. Nature has privileged such branched structures for increasing the efficiency of exchanges with the external medium; thus, the whole structure is of pivotal importance for these natural networks. On the contrary, it is generally believed that the properties of dendrimers are essentially related to their terminal groups, and that the internal structure plays the minor role of an ‘innocent' scaffold. Here we show that such an assertion is misleading, using convergent information from biological data (human monocytes activation) and all-atom molecular dynamics simulations on seven families of dendrimers (13 compounds) that we have synthesized, possessing identical terminal groups, but different internal structures. This work demonstrates that the scaffold of nanodrugs strongly influences their properties, somewhat reminiscent of the backbone of proteins.
Related Links	http://dx.doi.org/10.1038/ncomms8722
Starting Page	7722
File Format	PDF
ISSN	20411723
e-ISSN	20411723
Journal	Nature Communications
Volume Number	6
Language	English
Publisher	Nature Pub. Group
Publisher Date	2015-07-01
Access Restriction	Open
Rights Holder	Nature Pub. Group
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) Chemistry(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Physics and Astronomy Biochemistry, Genetics and Molecular Biology

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