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| Content Provider | PubMed Central |
|---|---|
| Author | Kitazawa, Taro Takechi, Masaki Hirasawa, Tatsuya Adachi, Noritaka Nicolas, Narboux-nême Kume, Hideaki Maeda, Kazuhiro Hirai, Tamami Sachiko, Miyagawa-tomita Kurihara, Yukiko Hitomi, Jiro Levi, Giovanni Shigeru, Kuratani Kurihara, Hiroki |
| Copyright Year | 2015 |
| Abstract | The amniote middle ear is a classical example of the evolutionary novelty. Although paleontological evidence supports the view that mammals and diapsids (modern reptiles and birds) independently acquired the middle ear after divergence from their common ancestor, the developmental bases of these transformations remain unknown. Here we show that lower-to-upper jaw transformation induced by inactivation of the Endothelin1-Dlx5/6 cascade involving Goosecoid results in loss of the tympanic membrane in mouse, but causes duplication of the tympanic membrane in chicken. Detailed anatomical analysis indicates that the relative positions of the primary jaw joint and first pharyngeal pouch led to the coupling of tympanic membrane formation with the lower jaw in mammals, but with the upper jaw in diapsids. We propose that differences in connection and release by various pharyngeal skeletal elements resulted in structural diversity, leading to the acquisition of the tympanic membrane in two distinct manners during amniote evolution. |
| Related Links | http://dx.doi.org/10.1038/ncomms7853 |
| Starting Page | 6853 |
| File Format | |
| ISSN | 20411723 |
| e-ISSN | 20411723 |
| Journal | Nature Communications |
| Volume Number | 6 |
| Language | English |
| Publisher | Nature Pub. Group |
| Publisher Date | 2015-04-01 |
| Access Restriction | Open |
| Rights Holder | Nature Pub. Group |
| Subject Keyword | Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) Chemistry(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Physics and Astronomy Biochemistry, Genetics and Molecular Biology |
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