NDLI: Dissociation of Learned Helplessness and Fear Conditioning in Mice: A Mouse Model of Depression

Content Provider	PubMed Central
Author	Landgraf, Dominic Long, Jaimie Andre, Der-avakian Streets, Margo Welsh, David K.
Editor	Alexandra, Kavushansky
Abstract	The state of being helpless is regarded as a central aspect of depression, and therefore the learned helplessness paradigm in rodents is commonly used as an animal model of depression. The term ‘learned helplessness’ refers to a deficit in escaping from an aversive situation after an animal is exposed to uncontrollable stress specifically, with a control/comparison group having been exposed to an equivalent amount of controllable stress. A key feature of learned helplessness is the transferability of helplessness to different situations, a phenomenon called ‘trans-situationality’. However, most studies in mice use learned helplessness protocols in which training and testing occur in the same environment and with the same type of stressor. Consequently, failures to escape may reflect conditioned fear of a particular environment, not a general change of the helpless state of an animal. For mice, there is no established learned helplessness protocol that includes the trans-situationality feature. Here we describe a simple and reliable learned helplessness protocol for mice, in which training and testing are carried out in different environments and with different types of stressors. We show that with our protocol approximately 50% of mice develop learned helplessness that is not attributable to fear conditioning.
Related Links	http://dx.doi.org/10.1371/journal.pone.0125892
Starting Page	125892
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	4
Volume Number	10
Language	English
Publisher	Public Library of Science
Publisher Date	2015-04-30
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Dissociation in Effective Treatment and Behavioral Phenotype Between Stress-Enhanced Fear Learning and Learned Helplessness

Synaptic potentiation onto habenula neurons in learned helplessness model of depression

Evidence of Antidepressive Effects of a Wakan-yaku, Hochuekkito, in Depression Model Mice with Learned-Helplessness Behavior

Evidence of Antidepressive Effects of a Wakan-yaku, Hochuekkito, in Depression Model Mice with Learned-Helplessness Behavior

Learned Helplessness in Rats: The Effects of Electroconvulsive Shock in an Animal Model of Depression

Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression

Prediction of Susceptibility to Learned Helplessness

Depression and Learned Helplessness: Task Difficulty and Success-Failure Attribution

Learned helplessness: unique features and translational value of a cognitive depression model

Dissociation of Learned Helplessness and Fear Conditioning in Mice: A Mouse Model of Depression

Similar Documents

Dissociation in Effective Treatment and Behavioral Phenotype Between Stress-Enhanced Fear Learning and Learned Helplessness

Synaptic potentiation onto habenula neurons in learned helplessness model of depression

Evidence of Antidepressive Effects of a Wakan-yaku, Hochuekkito, in Depression Model Mice with Learned-Helplessness Behavior

Evidence of Antidepressive Effects of a Wakan-yaku, Hochuekkito, in Depression Model Mice with Learned-Helplessness Behavior

Learned Helplessness in Rats: The Effects of Electroconvulsive Shock in an Animal Model of Depression

Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression

Prediction of Susceptibility to Learned Helplessness

Depression and Learned Helplessness: Task Difficulty and Success-Failure Attribution

Learned helplessness: unique features and translational value of a cognitive depression model

Dissociation of Learned Helplessness and Fear Conditioning in Mice: A Mouse Model of Depression