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| Content Provider | PubMed Central |
|---|---|
| Author | Maddison, Ben C. Spiropoulos, John Vickery, Christopher M. Lockey, Richard Owen, Jonathan P. Bishop, Keith Baker, Claire A. Gough, Kevin C. |
| Abstract | Ovine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months and eluted prion was used to challenge tg338 mice transgenic for ovine PrP. After one-day incubation on soil, two PrPSc phenotypes were present: G338 or Apl338ii. Thirteen months later some divergent PrPSc phenotypes were seen: a mixture of Apl338ii with either G338 or P338, and a completely novel PrPSc deposition, designated Cag338. The data show that prolonged ageing of scrapie prions within an environmental matrix may result in changes in the dominant PrPSc biological/biochemical properties. |
| Related Links | http://dx.doi.org/10.1186/s13567-015-0179-y |
| Starting Page | 46 |
| File Format | |
| ISSN | 12979716 |
| e-ISSN | 12979716 |
| Journal | Veterinary Research |
| Issue Number | 1 |
| Volume Number | 46 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2015-01-01 |
| Access Restriction | Open |
| Rights Holder | BioMed Central |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary |
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