NDLI: Towards Multidimensional Radiotherapy: Key Challenges for Treatment Individualisation

Content Provider	PubMed Central
Author	Toma-dasu, Iuliana Dasu, Alexandru
Copyright Year	2015
Abstract	Functional and molecular imaging of tumours have offered the possibility of redefining the target in cancer therapy and individualising the treatment with a multidimensional approach that aims to target the adverse processes known to impact negatively upon treatment result. Following the first theoretical attempts to include imaging information into treatment planning, it became clear that the biological features of interest for targeting exhibit considerable heterogeneity with respect to magnitude, spatial, and temporal distribution, both within one patient and between patients, which require more advanced solutions for the way the treatment is planned and adapted. Combining multiparameter information from imaging with predictive information from biopsies and molecular analyses as well as in treatment monitoring of tumour responsiveness appears to be the key approach to maximise the individualisation of treatment. This review paper aims to discuss some of the key challenges for incorporating into treatment planning and optimisation the radiobiological features of the tumour derived from pretreatment PET imaging of tumour metabolism, proliferation, and hypoxia and combining them with intreatment monitoring of responsiveness and other predictive factors with the ultimate aim of individualising the treatment towards the maximisation of response.
Related Links	http://dx.doi.org/10.1155/2015/934380
Starting Page	934380
File Format	PDF
ISSN	1748670X
e-ISSN	17486718
Journal	Computational and Mathematical Methods in Medicine
Volume Number	2015
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2015-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Modelling and Simulation Immunology and Microbiology(all) Applied Mathematics Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Applied Mathematics Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology Modeling and Simulation

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