NDLI: Diffusion Tensor Imaging Studies of Cervical Spondylotic Myelopathy:A Systemic Review and Meta-Analysis

Content Provider	PubMed Central
Author	Guan, Xiaofei Fan, Guoxin Wu, Xinbo Gu, Guangfei Gu, Xin Zhang, Hailong He, Shisheng
Editor	Shamji, Md
Copyright Year	2015
Abstract	A meta-analysis was conducted to assess alterations in measures of diffusiontensor imaging (DTI) in the patients of cervical spondylotic myelopathy (CSM),exploring the potential role of DTI as a diagnosis biomarker. A systematicsearch of all related studies written in English was conducted using PubMed, Webof Science, EMBASE, CINAHL, and Cochrane comparing CSM patients with healthycontrols. Key details for each study regarding participants, imaging techniques,and results were extracted. DTI measurements, such as fractional anisotropy(FA), apparent diffusion coefficient (ADC), and mean diffusivity (MD) werepooled to calculate the effect size (ES) by fixed or random effectsmeta-analysis. 14 studies involving 479 CSM patients and 278 controls wereidentified. Meta-analysis of the most compressed levels (MCL) of CSM patientsdemonstrated that FA was significantly reduced (ES -1.52, 95% CI -1.87 to -1.16,P < 0.001) and ADC was significantly increased (ES 1.09, 95% CI 0.89 to1.28, P < 0.001). In addition, a notable ES was found for lowered FA atC2-C3 for CSM vs. controls (ES -0.83, 95% CI -1.09 to -0.570, P < 0.001).Meta-regression analysis revealed that male ratio of CSM patients had asignificant effect on reduction of FA at MCL (P = 0.03). The meta-analysis ofDTI studies of CSM patients clearly demonstrated a significant FA reduction andADC increase compared with healthy subjects. This result supports the use of DTIparameters in differentiating CSM patients from health subjects. Futureresearches are required to investigate the diagnosis performance of DTI incervical spondylotic myelopathy.
Related Links	http://dx.doi.org/10.1371/journal.pone.0117707
Starting Page	117707
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	2
Volume Number	10
Language	English
Publisher	Public Library of Science
Publisher Date	2015-02-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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