NDLI: Innovative Delivery of siRNA to Solid Tumors by Super Carbonate Apatite

Content Provider	PubMed Central
Author	Xin, Wu Yamamoto, Hirofumi Nakanishi, Hiroyuki Yamamoto, Yuki Inoue, Akira Tei, Mitsuyoshi Hirose, Hajime Uemura, Mamoru Nishimura, Junichi Hata, Taishi Takemasa, Ichiro Mizushima, Tsunekazu Hossain, Sharif Akaike, Toshihiro Matsuura, Nariaki Doki, Yuichiro Mori, Masaki
Editor	Kim, Sung Wan
Copyright Year	2015
Abstract	RNA interference (RNAi) technology is currently being tested in clinical trials for a limited number of diseases. However, systemic delivery of small interfering RNA (siRNA) to solid tumors has not yet been achieved in clinics. Here, we introduce an in vivo pH-sensitive delivery system for siRNA using super carbonate apatite (sCA) nanoparticles, which is the smallest class of nanocarrier. These carriers consist simply of inorganic ions and accumulate specifically in tumors, yet they cause no serious adverse events in mice and monkeys. Intravenously administered sCA-siRNA abundantly accumulated in the cytoplasm of tumor cells at 4 h, indicating quick achievement of endosomal escape. sCA-survivin-siRNA induced apoptosis in HT29 tumors and significantly inhibited in vivo tumor growth of HCT116, to a greater extent than two other in vivo delivery reagents. With innovative in vivo delivery efficiency, sCA could be a useful nanoparticle for the therapy of solid tumors.
Related Links	http://dx.doi.org/10.1371/journal.pone.0116022
Starting Page	116022
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	3
Volume Number	10
Language	English
Publisher	Public Library of Science
Publisher Date	2015-03-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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