NDLI: Multisensory stimuli elicit altered oscillatory brain responses at gamma frequencies in patients with schizophrenia

Content Provider	PubMed Central
Author	Stone, David B. Coffman, Brian A. Bustillo, Juan R. Aine, Cheryl J. Stephen, Julia M.
Copyright Year	2014
Abstract	Deficits in auditory and visual unisensory responses are well documented in patients with schizophrenia; however, potential abnormalities elicited from multisensory audio-visual stimuli are less understood. Further, schizophrenia patients have shown abnormal patterns in task-related and task-independent oscillatory brain activity, particularly in the gamma frequency band. We examined oscillatory responses to basic unisensory and multisensory stimuli in schizophrenia patients (N = 46) and healthy controls (N = 57) using magnetoencephalography (MEG). Time-frequency decomposition was performed to determine regions of significant changes in gamma band power by group in response to unisensory and multisensory stimuli relative to baseline levels. Results showed significant behavioral differences between groups in response to unisensory and multisensory stimuli. In addition, time-frequency analysis revealed significant decreases and increases in gamma-band power in schizophrenia patients relative to healthy controls, which emerged both early and late over both sensory and frontal regions in response to unisensory and multisensory stimuli. Unisensory gamma-band power predicted multisensory gamma-band power differently by group. Furthermore, gamma-band power in these regions predicted performance in select measures of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) test battery differently by group. These results reveal a unique pattern of task-related gamma-band power in schizophrenia patients relative to controls that may indicate reduced inhibition in combination with impaired oscillatory mechanisms in patients with schizophrenia.
Related Links	http://dx.doi.org/10.3389/fnhum.2014.00788
Starting Page	788
File Format	PDF
ISSN	16625161
e-ISSN	16625161
Journal	Frontiers in Human Neuroscience
Volume Number	8
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2014-11-01
Access Restriction	Open
Rights Holder	Frontiers Media S.A.
Subject Keyword	Biological Psychiatry Behavioral Neuroscience Neuropsychology and Physiological Psychology Neurology Psychiatry and Mental health Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology Biological Psychiatry Behavioral Neuroscience Neuropsychology and Physiological Psychology Psychiatry and Mental Health

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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