NDLI: Abnormal development of sensory-motor, visual temporal and parahippocampal cortex in children with learning disabilities and borderline intellectual functioning

Content Provider	PubMed Central
Author	Baglio, Francesca Monia, Cabinio Ricci, Cristian Baglio, Gisella Lipari, Susanna Griffanti, Ludovica Preti, Maria G. Nemni, Raffaello Clerici, Mario Zanette, Michela Blasi, Valeria
Copyright Year	2014
Abstract	Borderline intellectual functioning (BIF) is a condition characterized by an intelligence quotient (IQ) between 70 and 85. BIF children present with cognitive, motor, social, and adaptive limitations that result in learning disabilities and are more likely to develop psychiatric disorders later in life. The aim of this study was to investigate brain morphometry and its relation to IQ level in BIF children. Thirteen children with BIF and 14 age- and sex-matched typically developing (TD) children were enrolled. All children underwent a full IQ assessment (WISC-III scale) and a magnetic resonance (MR) examination including conventional sequences to assess brain structural abnormalities and high resolution 3D images for voxel-based morphometry analysis. To investigate to what extent the group influenced gray matter (GM) volumes, both univariate and multivariate generalized linear model analysis of variance were used, and the varimax factor analysis was used to explore variable correlations and clusters among subjects. Results showed that BIF children, compared to controls have increased regional GM volume in bilateral sensorimotor and right posterior temporal cortices and decreased GM volume in the right parahippocampal gyrus. GM volumes were highly correlated with IQ indices. The present work is a case study of a group of BIF children showing that BIF is associated with abnormal cortical development in brain areas that have a pivotal role in motor, learning, and behavioral processes. Our findings, although allowing for little generalization to the general population, contribute to the very limited knowledge in this field. Future longitudinal MR studies will be useful in verifying whether cortical features can be modified over time even in association with rehabilitative intervention.
Related Links	http://dx.doi.org/10.3389/fnhum.2014.00806
Starting Page	806
File Format	PDF
ISSN	16625161
e-ISSN	16625161
Journal	Frontiers in Human Neuroscience
Volume Number	8
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2014-10-01
Access Restriction	Open
Rights Holder	Frontiers Media S.A.
Subject Keyword	Biological Psychiatry Behavioral Neuroscience Neuropsychology and Physiological Psychology Neurology Psychiatry and Mental health Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology Biological Psychiatry Behavioral Neuroscience Neuropsychology and Physiological Psychology Psychiatry and Mental Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The critical events for motor-sensory temporal recalibration

5 Hz repetitive transcranial magnetic stimulation over the ipsilesional sensory cortex enhances motor learning after stroke

Abnormal Connectivity and Brain Structure in Patients With Visual Snow

Differential Development of the Ventral Visual Cortex Extends Through Adolescence

A systematic review of non-motor rTMS induced motor cortex plasticity

Motor Cortex Neuroplasticity Following Brachial Plexus Transfer

Propagating Waves in Human Motor Cortex

Investigating developmental changes in sensory processing: visual mismatch response in healthy children

Social Functioning in Children with Brain Insult

Abnormal development of sensory-motor, visual temporal and parahippocampal cortex in children with learning disabilities and borderline intellectual functioning

Similar Documents

The critical events for motor-sensory temporal recalibration

5 Hz repetitive transcranial magnetic stimulation over the ipsilesional sensory cortex enhances motor learning after stroke

Abnormal Connectivity and Brain Structure in Patients With Visual Snow

Differential Development of the Ventral Visual Cortex Extends Through Adolescence

A systematic review of non-motor rTMS induced motor cortex plasticity

Motor Cortex Neuroplasticity Following Brachial Plexus Transfer

Propagating Waves in Human Motor Cortex

Investigating developmental changes in sensory processing: visual mismatch response in healthy children

Social Functioning in Children with Brain Insult

Abnormal development of sensory-motor, visual temporal and parahippocampal cortex in children with learning disabilities and borderline intellectual functioning