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| Content Provider | PubMed Central |
|---|---|
| Author | Lange, Lisa Sarah, Keppner-witter Grigat, Juline Spänkuch, Birgit |
| Copyright Year | 2014 |
| Abstract | PKCβ and Plk1 are fascinating targets in cancer therapy. Therefore, we combined Enzastaurin targeting PKCβ and SBE13 targeting Plk1 to test synergistic effects in cells with different p53 status. We analyzed cell proliferation and apoptosis induction, and did Western blot and FACScan analyses to examine the combined PKCβ and Plk1 inhibition. p53-wild-type cells are more resistant to the combinatorial treatment than p53-deficient cells, which displayed a synergistic reduction of cell proliferation after the combination. HeLa, MCF-7 and HCT116p53wt and HCT116p53-/- cells differed in their cell cycle distribution after combinatorial treatment in dependence on a functional p53-dependent G1/S checkpoint (p53-deficient cells showed an enrichment in S and G2/M, p53-wild-type cells in G0/G1 phase). hTERT-RPE1 cells did not show the synergistic effects of cancer cells. |
| Related Links | http://dx.doi.org/10.18632/oncotarget.1897 |
| Ending Page | 2275 |
| Page Count | 13 |
| Starting Page | 2263 |
| File Format | |
| ISSN | 19492553 |
| e-ISSN | 19492553 |
| Journal | Oncotarget |
| Issue Number | 8 |
| Volume Number | 5 |
| Language | English |
| Publisher | Impact Journals LLC |
| Publisher Date | 2014-04-01 |
| Access Restriction | Open |
| Rights Holder | Impact Journals LLC |
| Subject Keyword | Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
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