NDLI: Impact of Host Age and Parity on Susceptibility to Severe Urinary Tract Infection in a Murine Model

Content Provider	PubMed Central
Author	Kline, Kimberly A. Schwartz, Drew J. Gilbert, Nicole M. Lewis, Amanda L.
Editor	Hancock, Lynn E.
Copyright Year	2014
Abstract	The epidemiology and bacteriology of urinary tract infection (UTI) varies across the human lifespan, but the reasons for these differences are poorly understood. Using established monomicrobial and polymicrobial murine UTI models caused by uropathogenic Escherichia coli (UPEC) and/or Group B Streptococcus (GBS), we demonstrate age and parity as inter-related factors contributing to UTI susceptibility. Young nulliparous animals exhibited 10–100-fold higher bacterial titers compared to older animals. In contrast, multiparity was associated with more severe acute cystitis in older animals compared to age-matched nulliparous controls, particularly in the context of polymicrobial infection where UPEC titers were ∼1000-fold higher in the multiparous compared to the nulliparous host. Multiparity was also associated with significantly increased risk of chronic high titer UPEC cystitis and ascending pyelonephritis. Further evidence is provided that the increased UPEC load in multiparous animals required TLR4-signaling. Together, these data strongly suggest that the experience of childbearing fundamentally and permanently changes the urinary tract and its response to pathogens in a manner that increases susceptibility to severe UTI. Moreover, this murine model provides a system for dissecting these and other lifespan-associated risk factors contributing to severe UTI in at-risk groups.
Related Links	http://dx.doi.org/10.1371/journal.pone.0097798
Starting Page	97798
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	5
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-05-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Lower Respiratory Tract Infection Induced by a Genetically Modified Picornavirus in Its Natural Murine Host

The Age-Related Risk of Co-Existing Meningitis in Children with Urinary Tract Infection

Toll-Like Receptor Polymorphisms and Susceptibility to Urinary Tract Infections in Adult Women

β-Hemolysin/Cytolysin of Group B Streptococcus Enhances Host Inflammation but Is Dispensable for Establishment of Urinary Tract Infection

Urinary Tract Infection among Renal Transplant Recipients in Yemen

Cardiorenal Syndrome is Present in Human Fetuses with Severe, Isolated Urinary Tract Malformations

dsdA Does Not Affect Colonization of the Murine Urinary Tract by Escherichia coli CFT073

Role of Glycolipids in the Pathogenesis of Enterococcus faecalis Urinary Tract Infection

Urine Stasis Predisposes to Urinary Tract Infection by an Opportunistic Uropathogen in the Megabladder (Mgb) Mouse

Impact of Host Age and Parity on Susceptibility to Severe Urinary Tract Infection in a Murine Model

Similar Documents

Lower Respiratory Tract Infection Induced by a Genetically Modified Picornavirus in Its Natural Murine Host

The Age-Related Risk of Co-Existing Meningitis in Children with Urinary Tract Infection

Toll-Like Receptor Polymorphisms and Susceptibility to Urinary Tract Infections in Adult Women

β-Hemolysin/Cytolysin of Group B Streptococcus Enhances Host Inflammation but Is Dispensable for Establishment of Urinary Tract Infection

Urinary Tract Infection among Renal Transplant Recipients in Yemen

Cardiorenal Syndrome is Present in Human Fetuses with Severe, Isolated Urinary Tract Malformations

dsdA Does Not Affect Colonization of the Murine Urinary Tract by Escherichia coli CFT073

Role of Glycolipids in the Pathogenesis of Enterococcus faecalis Urinary Tract Infection

Urine Stasis Predisposes to Urinary Tract Infection by an Opportunistic Uropathogen in the Megabladder (Mgb) Mouse

Impact of Host Age and Parity on Susceptibility to Severe Urinary Tract Infection in a Murine Model