NDLI: New Susceptibility and Resistance HLA-DP Alleles to HBV-Related Diseases Identified by a Trans-Ethnic Association Study in Asia

Content Provider	PubMed Central
Author	Nishida, Nao Sawai, Hiromi Kashiwase, Koichi Minami, Mutsuhiko Sugiyama, Masaya Seto, Wai-kay Yuen, Man-fung Posuwan, Nawarat Poovorawan, Yong Ahn, Sang Hoon Han, Kwang-hyub Matsuura, Kentaro Tanaka, Yasuhito Kurosaki, Masayuki Asahina, Yasuhiro Izumi, Namiki Kang, Jong-hon Hige, Shuhei Ide, Tatsuya Yamamoto, Kazuhide Sakaida, Isao Murawaki, Yoshikazu Itoh, Yoshito Tamori, Akihiro Orito, Etsuro Yoichi, Hiasa Honda, Masao Kaneko, Shuichi Mita, Eiji Suzuki, Kazuyuki Hino, Keisuke Tanaka, Eiji Mochida, Satoshi Watanabe, Masaaki Eguchi, Yuichiro Masaki, Naohiko Murata, Kazumoto Korenaga, Masaaki Mawatari, Yoriko Ohashi, Jun Kawashima, Minae Tokunaga, Katsushi Mizokami, Masashi
Editor	Bonino, Ferruccio
Copyright Year	2014
Abstract	Previous studies have revealed the association between SNPs located on human leukocyte antigen (HLA) class II genes, including HLA-DP and HLA-DQ, and chronic hepatitis B virus (HBV) infection, mainly in Asian populations. HLA-DP alleles or haplotypes associated with chronic HBV infection or disease progression have not been fully identified in Asian populations. We performed trans-ethnic association analyses of HLA-DPA1, HLA-DPB1 alleles and haplotypes with hepatitis B virus infection and disease progression among Asian populations comprising Japanese, Korean, Hong Kong, and Thai subjects. To assess the association between HLA-DP and chronic HBV infection and disease progression, we conducted high-resolution (4-digit) HLA-DPA1 and HLA-DPB1 genotyping in a total of 3,167 samples, including HBV patients, HBV-resolved individuals and healthy controls. Trans-ethnic association analyses among Asian populations identified a new risk allele HLA-DPB109∶01 (P = 1.36×10−6; OR = 1.97; 95% CI, 1.50–2.59) and a new protective allele DPB102∶01 (P = 5.22×10−6; OR = 0.68; 95% CI, 0.58–0.81) to chronic HBV infection, in addition to the previously reported alleles. Moreover, DPB1*02∶01 was also associated with a decreased risk of disease progression in chronic HBV patients among Asian populations (P = 1.55×10−7; OR = 0.50; 95% CI, 0.39–0.65). Trans-ethnic association analyses identified Asian-specific associations of HLA-DP alleles and haplotypes with HBV infection or disease progression. The present findings will serve as a base for future functional studies of HLA-DP molecules in order to understand the pathogenesis of HBV infection and the development of hepatocellular carcinoma.
Related Links	http://dx.doi.org/10.1371/journal.pone.0086449
Starting Page	86449
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	2
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-02-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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