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| Content Provider | PubMed Central |
|---|---|
| Author | Rasmus, Kristin C. O'neill, Casey E. Bachtell, Ryan K. Cooper, Donald C. |
| Copyright Year | 2013 |
| Abstract | The canonical transient receptor potential (TRPC) family of Ca2+ permeable, non-selective cation channels is abundantly expressed throughout the brain, and plays a pivotal role in modulating cellular excitability.Unlike other TRPC channels, TRPC4 subtype expression in the adult rodent brain is restricted to a network of structures that receive dopaminergic innervation, suggesting an association with motivation- and reward-related behaviors. We hypothesized that these channels may play a critical role in dopamine-dependent drug-seeking behaviors. Here, we gathered data testingtrpc4 knockout (KO) rats and wild-type (WT) littermates in the acquisition of a natural sucrose reward (10 days), and cocaine self-administration (13 days) at 0.5 mg/kg/infusion. Rats lacking thetrpc4 gene (trpc4-KO) learned to lever press for sucrose to a similar degree as their WT controls. However, when they were switched to cocaine, thetrpc4-KO rats had substantially reduced cocaine-paired lever pressing compared to WT controls. No obvious group differences in inactive lever pressing were observed, for any time, during cocaine self-administration. |
| Related Links | http://dx.doi.org/10.12688/f1000research.2-110.v1 |
| Starting Page | 110 |
| File Format | |
| ISSN | 20461402 |
| e-ISSN | 20461402 |
| Journal | F1000Research |
| Volume Number | 2 |
| Language | English |
| Publisher | F1000Research |
| Publisher Date | 2013-04-17 |
| Access Restriction | Open |
| Rights Holder | F1000Research |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics |
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