NDLI: Effects of Atrial Natriuretic Peptide on Bicarbonate Transport in Long- and Short-Looped Medullary Thick Ascending Limbs of Rats

Content Provider	PubMed Central
Author	Hiroshi, Nonoguchi Izumi, Yuichiro Nakayama, Yushi Matsuzaki, Takanobu Yasuoka, Yukiko Inoue, Takeaki Inoue, Hideki Mouri, Tomohiko Kawahara, Katsumasa Saito, Hideyuki Tomita, Kimio
Editor	Fenton, Robert A.
Copyright Year	2013
Abstract	Atrial natriuretic peptide (ANP) is known to influence NaCl transport in the medullary thick ascending limbs (MAL), where the largest NaCl reabsorption occurs among distal nephron segments in response to arginine vasopressin (AVP). In the present study, we investigated the effect of ANP on bicarbonate (HCO3 −) transport in the MAL using an isolated tubule perfusion technique. The HCO3 − concentration was measured using free-flow ultramicro-fluorometer. We first observed basal HCO3 − reabsorption in both long- and short-looped MALs (lMALs, and sMALs, respectively). AVP inhibited HCO3 − reabsorption in both lMALs and sMALs, whereas ANP did not change HCO3 − transport. However, in the presence of AVP, ANP restored the HCO3 − reabsorption inhibited by AVP both in lMAL and sMAL. The effects of ANP on HCO3 − transport was mimicked by cyclic GMP. The mRNA expression level of the vasopressin V2 receptor in lMALs was significantly higher than in sMALs, whereas expression of the V1a receptor was unchanged. In summary, AVP inhibits HCO3 − transport, and ANP counteracts the action of AVP on HCO3 − transport both in lMALs and sMALs.
Related Links	http://dx.doi.org/10.1371/journal.pone.0083146
Starting Page	83146
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	12
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-12-23
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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