NDLI: Optimal control of gene expression for fast proteome adaptation to environmental change

Content Provider	PubMed Central
Author	Pavlov, Michael Y. Ehrenberg, Måns
Abstract	For rapid growth in different environments, bacterial cells must perpetually adapt their enzyme levels to efficiently metabolize different sets of nutrients in different surroundings. When environmental shifts are frequent and swift, the bacteria must rapidly adjust the levels of all their different proteins—their proteome. We have theoretically identified the best gene-expression strategy for rapid proteome adjustment upon environmental change and found simple, general descriptions for the dynamic change of the proteome composition and the adaptation time following such optimal strategy. Our work predicts important aspects of bacterial physiology and connects it with the population genetics and evolution of bacterial populations. Our theory is relevant to understanding antibiotic resistance and the development of strategies for maximal biomass production.
Related Links	http://dx.doi.org/10.1073/pnas.1309356110
Ending Page	20532
Page Count	6
Starting Page	20527
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	51
Volume Number	110
Language	English
Publisher	National Academy of Sciences
Publisher Date	2013-12-17
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Optimal control of gene expression for fast proteome adaptation to environmental change