NDLI: Collective polarization model for gradient sensing via Dachsous-Fat intercellular signaling

Content Provider	PubMed Central
Author	Mani, Madhav Goyal, Sidhartha Irvine, Kenneth D. Shraiman, Boris I.
Abstract	Morphogenesis is a biological process that generates the physical form and structure of multicellular organisms. Although many of the genes controlling morphogenesis are known, little is understood of the mechanisms that define tissue shape and size. Prominent among these mechanisms is the contact signaling between cells mediated by two cell adhesion-type proteins Dachsous and Fat, which regulate cell division in response to the spatially graded distribution of morphogens, factors governing tissue patterning and growth. Here, based on the known behavior of this signaling pathway, we develop a model of the underlying mechanism that relates signaling to the polarization of Dachsous/Fat heterodimers on cell interfaces. This model explains observed phenotypes, makes quantitative predictions, and provides a framework for further experimental studies.
Related Links	http://dx.doi.org/10.1073/pnas.1307459110
Ending Page	20425
Page Count	6
Starting Page	20420
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	51
Volume Number	110
Language	English
Publisher	National Academy of Sciences
Publisher Date	2013-12-17
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Collective polarization model for gradient sensing via Dachsous-Fat intercellular signaling