NDLI: VEGF-Mediated Proliferation of Human Adipose Tissue-Derived Stem Cells

Content Provider	PubMed Central
Author	Chen, Guangfeng Shi, Xiujuan Sun, Chen Li, Min Zhou, Qing Zhang, Chen Huang, Jun Qiu, Yu Wen, Xiangyi Zhang, Yan Zhang, Yushan Yang, Shuzhang Lu, Lixia Zhang, Jieping Yuan, Qionglan Lu, Jianwei Xu, Guotong Xue, Yunyun Jin, Zibing Jiang, Cizhong Ying, Ming Liu, Xiaoqing
Editor	Cooney, Austin John
Copyright Year	2013
Abstract	Human adipose tissue-derived stem cells (ADSCs) are an attractive multipotent stem cell source with therapeutic applicability across diverse fields for the repair and regeneration of acute and chronically damaged tissues. In recent years, there has been increasing interest in ADSC for tissue engineering applications. However, the mechanisms underlying the regulation of ADSC proliferation are not fully understood. Here we show that 47 transcripts are up-regulated while 23 are down-regulated in ADSC compared to terminally differentiated cells based on global mRNA profiling and microRNA profiling. Among the up-regulated genes, the expression of vascular endothelial growth factor (VEGF) is fine-tuned by miR-199a-5p. Further investigation indicates that VEGF accelerates ADSC proliferation whereas the multipotency of ADSC remains stable in terms of adipogenic, chondrogenic and osteogenic potentials after VEGF treatment, suggesting that VEGF may serve as an excellent supplement for accelerating ADSC proliferation during in vitro expansion.
Related Links	http://dx.doi.org/10.1371/journal.pone.0073673
Starting Page	73673
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	10
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-10-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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