NDLI: The Frequency, Clinical Significance, and Pathological Features of Chronic Chorioamnionitis: A Lesion Associated with Spontaneous Preterm Birth

Please wait, while we are loading the content...

The Frequency, Clinical Significance, and Pathological Features of Chronic Chorioamnionitis: A Lesion Associated with Spontaneous Preterm Birth

Content Provider	PubMed Central
Author	Kim, Chong Jai Romero, Roberto Pedro, Kusanovic Juan Yoo, Wonsuk Dong, Zhong Topping, Vanessa Gotsch, Francesca Yoon, Bo Hyun Chi, Je Geun Kim, Jung-sun
Abstract	Acute chorioamnionitis (ACA) is a well-established lesion of the placenta in cases with intra-amniotic infection. In contrast, the clinicopathologic significance of chronic chorioamnionitis (CCA) is unclear. This study was conducted to determine the frequency and severity of CCA in normal pregnancy and various pregnancy complications. Placentas from the following patient groups were studied: 1) term not in labor (TNL; n=100), 2) term in labor (TIL; n=100), 3) preterm labor (PTL; n=100), 4) preterm prelabor rupture of the membranes (PPROM; n=100), 5) preeclampsia at term (TPE; n=100), 6) preterm preeclampsia (PPE; n=100), and 7) small-for-gestational-age at term (SGA; n=100). Amniotic fluid CXCL10 concentration was measured in 64 patients. CXCL9, CXCL10, and CXCL11 mRNA expressions in the chorioamniotic membranes were assessed by real-time quantitative RT-PCR. The frequency of CCA in PTL and PPROM groups was 34% and 39%, respectively, which was higher than those of normal term placentas (TNL 19%, TIL 8%; p<0.05 each). The frequency of CCA in TPE, PPE and SGA groups was 23%, 16%, and 13%, respectively. Concomitant villitis of unknown etiology (VUE) was found in 38.2% and 35.9% of PTL and PPROM cases with CCA, respectively. Interestingly, the median gestational age of preterm CCA cases was higher than that of ACA cases (p<0.05). The median amniotic fluid CXCL10 concentration was higher in cases with CCA than in those without, in both PTL and PPROM groups (p<0.05 and p<0.01, respectively). CXCL9, CXCL10, and CXCL11 mRNA expression in the chorioamniotic membranes was also higher in CCA cases than in those without CCA (p<0.05). We propose that CCA defines a common placental pathologic lesion among the PTL and PPROM groups, especially in cases of late preterm birth. Its association with VUE and the chemokine profile in amniotic fluid suggests an immunological origin, akin to transplantation rejection and graft-versus-host disease in the chorioamniotic membranes.
Related Links	http://dx.doi.org/10.1038/modpathol.2010.73
Ending Page	1011
Page Count	12
Starting Page	1000
File Format	PDF
ISSN	08933952
e-ISSN	15300285
Journal	Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Issue Number	7
Volume Number	23
Language	English
Publisher Date	2010-07-01
Access Restriction	Open
Subject Keyword	Pathology and Forensic Medicine Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

N,N-Dimethylacetamide Regulates the Proinflammatory Response Associated with Endotoxin and Prevents Preterm Birth

Rare Haemophilus influenzae Placental Infection Associated With Acute Chorioamnionitis and Acute Funisitis in a Preterm Delivery

The placental microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis

Tuberous sclerosis-associated renal cell carcinoma. Clinical, pathological, and genetic features.

Pathological features of colorectal carcinomas in MYH-associated polyposis

RENAL BIOPSY: CLINICAL AND PATHOLOGICAL SIGNIFICANCE

In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features.

Blockade of Endothelin-1 with a Novel Series of 1,3,6-Trisubstituted-2-Carboxy-Quinol-4-Ones Controls Infection-Associated Preterm Birth

Pulmonary pathological features in coronavirus associated severe acute respiratory syndrome (SARS)

The Frequency, Clinical Significance, and Pathological Features of Chronic Chorioamnionitis: A Lesion Associated with Spontaneous Preterm Birth

Similar Documents

N,N-Dimethylacetamide Regulates the Proinflammatory Response Associated with Endotoxin and Prevents Preterm Birth

Rare Haemophilus influenzae Placental Infection Associated With Acute Chorioamnionitis and Acute Funisitis in a Preterm Delivery

The placental microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis

Tuberous sclerosis-associated renal cell carcinoma. Clinical, pathological, and genetic features.

Pathological features of colorectal carcinomas in MYH-associated polyposis

RENAL BIOPSY: CLINICAL AND PATHOLOGICAL SIGNIFICANCE

In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features.

Blockade of Endothelin-1 with a Novel Series of 1,3,6-Trisubstituted-2-Carboxy-Quinol-4-Ones Controls Infection-Associated Preterm Birth

Pulmonary pathological features in coronavirus associated severe acute respiratory syndrome (SARS)

The Frequency, Clinical Significance, and Pathological Features of Chronic Chorioamnionitis: A Lesion Associated with Spontaneous Preterm Birth