NDLI: Ephexin4-mediated promotion of cell migration and anoikis resistance is regulated by serine 897 phosphorylation of EphA2 ☆

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Ephexin4-mediated promotion of cell migration and anoikis resistance is regulated by serine 897 phosphorylation of EphA2 ☆

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Ephexin4-mediated promotion of cell migration and anoikis resistance is regulated by serine 897 phosphorylation of EphA2 ☆

Content Provider	PubMed Central
Author	Kawai, Hiromu Kobayashi, Masakazu Nao, Hiramoto-yamaki Harada, Kohei Negishi, Manabu Katoh, Hironori
Copyright Year	2013
Abstract	EphA2 is activated through phosphorylation on serine 897 (S897) by Akt to promote cancer cell motility and invasion, independently of stimulation by ephrin, its ligand. Here we show that S897 phosphorylation of EphA2 strengthens the interaction between EphA2 and Ephexin4, a guanine nucleotide exchange factor for the small GTPase RhoG. S897A mutation of EphA2 abolished the EphA2/Ephexin4-mediated RhoG activation, promotion of cell migration, and resistance to anoikis. Our results suggest that S897-phosphorylated EphA2 recruits Ephexin4 to promote cell migration and anoikis resistance, providing a molecular link between S897 phosphorylation of EphA2 and tumor progression.
Related Links	http://dx.doi.org/10.1016/j.fob.2013.01.002
Ending Page	82
Page Count	5
Starting Page	78
File Format	PDF
ISSN	22115463
e-ISSN	22115463
Journal	FEBS Open Bio
Volume Number	3
Language	English
Publisher	Elsevier
Publisher Date	2013-01-01
Access Restriction	Open
Rights Holder	Elsevier
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology

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