NDLI: The Timing Statistics of Spontaneous Calcium Release in Cardiac Myocytes

Content Provider	PubMed Central
Author	Asfaw, Mesfin Alvarez-lacalle, Enric Yohannes, Shiferaw
Editor	Xie, Lai-hua
Copyright Year	2013
Abstract	A variety of cardiac arrhythmias are initiated by a focal excitation that disrupts the regular beating of the heart. In some cases it is known that these excitations are due to calcium (Ca) release from the sarcoplasmic reticulum (SR) via propagating subcellular Ca waves. However, it is not understood what are the physiological factors that determine the timing of these excitations at both the subcellular and tissue level. In this paper we apply analytic and numerical approaches to determine the timing statistics of spontaneous Ca release (SCR) in a simplified model of a cardiac myocyte. In particular, we compute the mean first passage time (MFPT) to SCR, in the case where SCR is initiated by spontaneous Ca sparks, and demonstrate that this quantity exhibits either an algebraic or exponential dependence on system parameters. Based on this analysis we identify the necessary requirements so that SCR occurs on a time scale comparable to the cardiac cycle. Finally, we study how SCR is synchronized across many cells in cardiac tissue, and identify a quantitative measure that determines the relative timing of SCR in an ensemble of cells. Using this approach we identify the physiological conditions so that cell-to-cell variations in the timing of SCR is small compared to the typical duration of an SCR event. We argue further that under these conditions inward currents due to SCR can summate and generate arrhythmogenic triggered excitations in cardiac tissue.
Related Links	http://dx.doi.org/10.1371/journal.pone.0062967
Starting Page	62967
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	5
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-05-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Correction: The Timing Statistics of Spontaneous Calcium Release in Cardiac Myocytes

Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload

Modeling Calcium Wave Based on Anomalous Subdiffusion of Calcium Sparks in Cardiac Myocytes

Magnesium Homeostasis in Cardiac Myocytes of Mg-Deficient Rats

PI3Ks Maintain the Structural Integrity of T-Tubules in Cardiac Myocytes

Modulation of sarcoplasmic reticulum calcium release by calsequestrin in cardiac myocytes

Instabilities of the resting state in a mathematical model of calcium handling in cardiac myocytes

Disruption of Learned Timing in P/Q Calcium Channel Mutants

Pre & Postsynaptic Tuning of Action Potential Timing by Spontaneous GABAergic Activity

The Timing Statistics of Spontaneous Calcium Release in Cardiac Myocytes

Similar Documents

Correction: The Timing Statistics of Spontaneous Calcium Release in Cardiac Myocytes

Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload

Modeling Calcium Wave Based on Anomalous Subdiffusion of Calcium Sparks in Cardiac Myocytes

Magnesium Homeostasis in Cardiac Myocytes of Mg-Deficient Rats

PI3Ks Maintain the Structural Integrity of T-Tubules in Cardiac Myocytes

Modulation of sarcoplasmic reticulum calcium release by calsequestrin in cardiac myocytes

Instabilities of the resting state in a mathematical model of calcium handling in cardiac myocytes

Disruption of Learned Timing in P/Q Calcium Channel Mutants

Pre & Postsynaptic Tuning of Action Potential Timing by Spontaneous GABAergic Activity

The Timing Statistics of Spontaneous Calcium Release in Cardiac Myocytes