NDLI: Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats

Content Provider	PubMed Central
Author	Machado, Ricardo Borges Sergio, Tufik Suchecki, Deborah
Editor	Tosini, Gianluca
Copyright Year	2013
Abstract	Sleep is regulated by humoral and homeostatic processes. If on one hand chronic elevation of stress hormones impair sleep, on the other hand, rapid eye movement (REM) sleep deprivation induces elevation of glucocorticoids and time of REM sleep during the recovery period. In the present study we sought to examine whether manipulations of corticosterone levels during REM sleep deprivation would alter the subsequent sleep rebound. Adult male Wistar rats were fit with electrodes for sleep monitoring and submitted to four days of REM sleep deprivation under repeated corticosterone or metyrapone (an inhibitor of corticosterone synthesis) administration. Sleep parameters were continuously recorded throughout the sleep deprivation period and during 3 days of sleep recovery. Plasma levels of adrenocorticotropic hormone and corticosterone were also evaluated. Metyrapone treatment prevented the elevation of corticosterone plasma levels induced by REM sleep deprivation, whereas corticosterone administration to REM sleep-deprived rats resulted in lower corticosterone levels than in non-sleep deprived rats. Nonetheless, both corticosterone and metyrapone administration led to several alterations on sleep homeostasis, including reductions in the amount of non-REM and REM sleep during the recovery period, although corticosterone increased delta activity (1.0–4.0 Hz) during REM sleep deprivation. Metyrapone treatment of REM sleep-deprived rats reduced the number of REM sleep episodes. In conclusion, reduction of corticosterone levels during REM sleep deprivation resulted in impairment of sleep rebound, suggesting that physiological elevation of corticosterone levels resulting from REM sleep deprivation is necessary for plentiful recovery of sleep after this stressful event.
Related Links	http://dx.doi.org/10.1371/journal.pone.0063520
Starting Page	63520
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	5
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-05-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Selective REM Sleep Deprivation Improves Expectation-Related Placebo Analgesia

Selective REM-Sleep Deprivation Does Not Diminish Emotional Memory Consolidation in Young Healthy Subjects

Notch signaling modulates sleep homeostasis and learning after sleep deprivation in Drosophila

Sleep Deprivation Impairs Consolidation of Cued Fear Memory in Rats

Impact of Acute Sleep Deprivation on Sarcasm Detection

Effects of Daytime Food Intake on Memory Consolidation during Sleep or Sleep Deprivation

Effects of Chronic Sleep Deprivation on the Extracellular Signal-Regulated Kinase Pathway in the Temporomandibular Joint of Rats

Correction: Effects of Chronic Sleep Deprivation on the Extracellular Signal-Regulated Kinase Pathway in the Temporomandibular Joint of Rats

Aging Worsens the Effects of Sleep Deprivation on Postural Control

Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats

Similar Documents

Selective REM Sleep Deprivation Improves Expectation-Related Placebo Analgesia

Selective REM-Sleep Deprivation Does Not Diminish Emotional Memory Consolidation in Young Healthy Subjects

Notch signaling modulates sleep homeostasis and learning after sleep deprivation in Drosophila

Sleep Deprivation Impairs Consolidation of Cued Fear Memory in Rats

Impact of Acute Sleep Deprivation on Sarcasm Detection

Effects of Daytime Food Intake on Memory Consolidation during Sleep or Sleep Deprivation

Effects of Chronic Sleep Deprivation on the Extracellular Signal-Regulated Kinase Pathway in the Temporomandibular Joint of Rats

Correction: Effects of Chronic Sleep Deprivation on the Extracellular Signal-Regulated Kinase Pathway in the Temporomandibular Joint of Rats

Aging Worsens the Effects of Sleep Deprivation on Postural Control

Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats