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| Content Provider | PubMed Central |
|---|---|
| Author | Østergaard, Leif Jespersen, Sune Nørhøj Kim, Mouridsen Mikkelsen, Irene Klærke Jonsdottír, Kristjana Ýr Tietze, Anna Blicher, Jakob Udby Rasmus, Aamand Hjort, Niels Iversen, Nina Kerting Cai, Changsi Hougaard, Kristina Dupont Simonsen, Claus Z. Von, Weitzel-mudersbach Paul Boris, Modrau Nagenthiraja, Kartheeban Ribe, Lars Riisgaard Hansen, Mikkel Bo Lise, Bekke Susanne Dahlman, Martin Gervais Puig, Josep Pedraza, Salvador Serena, Joaquín Cho, Tae-hee Siemonsen, Susanne Thomalla, Götz Fiehler, Jens Norbert, Nighoghossian Andersen, Grethe |
| Copyright Year | 2013 |
| Abstract | The pathophysiology of cerebral ischemia is traditionally understood in relation to reductions in cerebral blood flow (CBF). However, a recent reanalysis of the flow-diffusion equation shows that increased capillary transit time heterogeneity (CTTH) can reduce the oxygen extraction efficacy in brain tissue for a given CBF. Changes in capillary morphology are typical of conditions predisposing to stroke and of experimental ischemia. Changes in capillary flow patterns have been observed by direct microscopy in animal models of ischemia and by indirect methods in humans stroke, but their metabolic significance remain unclear. We modeled the effects of progressive increases in CTTH on the way in which brain tissue can secure sufficient oxygen to meet its metabolic needs. Our analysis predicts that as CTTH increases, CBF responses to functional activation and to vasodilators must be suppressed to maintain sufficient tissue oxygenation. Reductions in CBF, increases in CTTH, and combinations thereof can seemingly trigger a critical lack of oxygen in brain tissue, and the restoration of capillary perfusion patterns therefore appears to be crucial for the restoration of the tissue oxygenation after ischemic episodes. In this review, we discuss the possible implications of these findings for the prevention, diagnosis, and treatment of acute stroke. |
| Related Links | http://dx.doi.org/10.1038/jcbfm.2013.18 |
| Ending Page | 648 |
| Page Count | 14 |
| Starting Page | 635 |
| File Format | |
| ISSN | 0271678X |
| e-ISSN | 15597016 |
| Journal | Journal of Cerebral Blood Flow & Metabolism |
| Issue Number | 5 |
| Volume Number | 33 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2013-05-01 |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Neurology Clinical Neurology Cardiology and Cardiovascular Medicine Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Neurology (clinical) Cardiology and Cardiovascular Medicine |
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