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| Content Provider | PubMed Central |
|---|---|
| Author | Clarkson, Andrew N. López-valdés, Héctor E. Overman, Justine J. Charles, Andrew C. Brennan, K. C. Carmichael, S. Thomas |
| Copyright Year | 2013 |
| Abstract | Recent studies show a limited capacity for neural repair after stroke, which includes remapping of sensorimotor functions and sprouting of new connections. However, physiologic and connectional plasticity of sensory maps during long-term functional recovery in the mouse have not been determined. Using a photothrombotic stroke model, we targeted the motor cortex, which we show results in lasting behavioral deficits on the grid-walking and in the cylinder tasks out to 8 weeks after stroke. Mice recovered performance in a skilled reaching task, showing no deficit from week 2 after stroke. Long-term optical intrinsic signal imaging revealed functional reorganization of sensory cortical maps for both forelimb and hindlimb, with more diffuse sensory physiologic maps. There was a small but significant increase in motor neuron projections within the areas of functional cortical reorganization as assessed using the neuroanatomic tracer biotinylated dextran amine. These findings show that the sensorimotor cortex undergoes remapping of cortical functions and axonal sprouting within the same regions during recovery after stroke. This suggests a linked structural and physiologic plasticity underlying recovery. Combined long-term structural and functional mapping after stroke in the mouse is practical and provides a rich data set for mechanistic analysis of stroke recovery. |
| Related Links | http://dx.doi.org/10.1038/jcbfm.2013.7 |
| Ending Page | 723 |
| Page Count | 8 |
| Starting Page | 716 |
| File Format | |
| ISSN | 0271678X |
| e-ISSN | 15597016 |
| Journal | Journal of Cerebral Blood Flow & Metabolism |
| Issue Number | 5 |
| Volume Number | 33 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2013-05-01 |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Neurology Clinical Neurology Cardiology and Cardiovascular Medicine Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Neurology (clinical) Cardiology and Cardiovascular Medicine |
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