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| Content Provider | PubMed Central |
|---|---|
| Author | Geisler, Stefanie Willuweit, Antje Schroeter, Michael Zilles, Karl Hamacher, Kurt Norbert, Galldiks Shah, Nadim J. Coenen, Heinz H. Langen, Karl-josef |
| Copyright Year | 2013 |
| Abstract | After cerebral ischemia or trauma, secondary neurodegeneration may occur in brain regions remote from the lesion. Little is known about the capacity of cerebral gliomas to induce secondary neurodegeneration. A previous study showed that cis-4-[18F]fluoro-𝒟proline (𝒟cis-[18F]FPro) detects secondary reactions of thalamic nuclei after cortical infarction with high sensitivity. Here we investigated the potential of 𝒟cis-[18F]FPro to detect neuronal reactions in remote brain areas in the F98 rat glioma model using ex vivo autoradiography. Although the tumor tissue of F98 gliomas showed no significant 𝒟-cis-[18F]FPro uptake, we observed prominent tracer uptake in 7 of 10 animals in the nuclei of the ipsilateral thalamus, which varied with the specific connectivity with the cortical areas affected by the tumor. In addition, strong 𝒟cis-[18F]FPro accumulation was noted in the hippocampal area CA1 in two animals with ipsilateral F98 gliomas involving hippocampal subarea CA3 rostral to that area. Furthermore, focal 𝒟cis-[18F]FPro uptake was present in the necrotic center of the tumors. Cis-4-[18F]fluoro-𝒟proline uptake was accompanied by microglial activation in the thalamus, in the hippocampus, and in the necrotic center of the tumors. The data suggest that brain tumors induce secondary neuronal reactions in remote brain areas, which may be detected by positron emission tomography (PET) using 𝒟cis-[18F]FPro. |
| Related Links | http://dx.doi.org/10.1038/jcbfm.2013.8 |
| Ending Page | 731 |
| Page Count | 8 |
| Starting Page | 724 |
| File Format | |
| ISSN | 0271678X |
| e-ISSN | 15597016 |
| Journal | Journal of Cerebral Blood Flow & Metabolism |
| Issue Number | 5 |
| Volume Number | 33 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2013-05-01 |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Neurology Clinical Neurology Cardiology and Cardiovascular Medicine Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Neurology (clinical) Cardiology and Cardiovascular Medicine |
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