NDLI: Internalization of Met Requires the Co-Receptor CD44v6 and Its Link to ERM Proteins

Content Provider	PubMed Central
Author	Hasenauer, Susanne Malinger, Dieter David, Koschut Pace, Giuseppina Matzke, Alexandra Au, Anja Von Orian-rousseau, Véronique
Editor	Cheng, Jin Q.
Copyright Year	2013
Abstract	Receptor Tyrosine Kinases (RTKs) are involved in many cellular processes and play a major role in the control of cell fate. For these reasons, RTK activation is maintained under tight control. Met is an essential RTK that induces proliferation, differentiation, migration, survival and branching morphogenesis. Deregulation of Met by overexpression, amplification or lack of effective degradation leads to cancer and metastasis. We have shown that Met relies on CD44v6 for its activation and for signaling in several cancer cell lines and also in primary cells. In this paper, we show that internalization of Met is dependent on CD44v6 and the binding of Ezrin to the CD44v6 cytoplasmic domain. Both CD44v6 and Met are co-internalized upon Hepatocyte Growth Factor induction suggesting that Met-induced signaling from the endosomes relies on its collaboration with CD44v6 and the link to the cytoskeleton provided by ERM proteins.
Related Links	http://dx.doi.org/10.1371/journal.pone.0062357
Starting Page	62357
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	4
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-04-23
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Correction: Internalization of Met Requires the Co-Receptor CD44v6 and Its Link to ERM Proteins

Hepatocyte Growth Factor-induced Ras Activation Requires ERM Proteins Linked to Both CD44v6 and F-Actin

Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation.

Activation of Ras Requires the ERM-Dependent Link of Actin to the Plasma Membrane

A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.

Polarization of the Yeast Pheromone Receptor Requires Its Internalization but Not Actin-dependent Secretion

Co-migration and internalization of transferrin and its receptor on K562 cells

EGF receptor ubiquitination is not necessary for its internalization

Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo.

Internalization of Met Requires the Co-Receptor CD44v6 and Its Link to ERM Proteins

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Correction: Internalization of Met Requires the Co-Receptor CD44v6 and Its Link to ERM Proteins

Hepatocyte Growth Factor-induced Ras Activation Requires ERM Proteins Linked to Both CD44v6 and F-Actin

Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation.

Activation of Ras Requires the ERM-Dependent Link of Actin to the Plasma Membrane

A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.

Polarization of the Yeast Pheromone Receptor Requires Its Internalization but Not Actin-dependent Secretion

Co-migration and internalization of transferrin and its receptor on K562 cells

EGF receptor ubiquitination is not necessary for its internalization

Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo.

Internalization of Met Requires the Co-Receptor CD44v6 and Its Link to ERM Proteins