NDLI: Diminished Activation of Motor Working-Memory Networks in Parkinson's Disease

Content Provider	PubMed Central
Author	Claudia, Rottschy Kleiman, Alexandra Dogan, Imis Langner, Robert Mirzazade, Shahram Martin, Kronenbuerger Werner, Cornelius Shah, N. Jon Schulz, Jörg B. Eickhoff, Simon B. Reetz, Kathrin
Editor	Maurits, Natasha M.
Copyright Year	2013
Abstract	Parkinson's disease (PD) is characterized by typical extrapyramidal motor features and increasingly recognized non-motor symptoms such as working memory (WM) deficits. Using functional magnetic resonance imaging (fMRI), we investigated differences in neuronal activation during a motor WM task in 23 non-demented PD patients and 23 age- and gender-matched healthy controls. Participants had to memorize and retype variably long visuo-spatial stimulus sequences after short or long delays (immediate or delayed serial recall). PD patients showed deficient WM performance compared to controls, which was accompanied by reduced encoding-related activation in WM-related regions. Mirroring slower motor initiation and execution, reduced activation in motor structures such as the basal ganglia and superior parietal cortex was detected for both immediate and delayed recall. Increased activation in limbic, parietal and cerebellar regions was found during delayed recall only. Increased load-related activation for delayed recall was found in the posterior midline and the cerebellum. Overall, our results demonstrate that impairment of WM in PD is primarily associated with a widespread reduction of task-relevant activation, whereas additional parietal, limbic and cerebellar regions become more activated relative to matched controls. While the reduced WM-related activity mirrors the deficient WM performance, the additional recruitment may point to either dysfunctional compensatory strategies or detrimental crosstalk from “default-mode” regions, contributing to the observed impairment.
Related Links	http://dx.doi.org/10.1371/journal.pone.0061786
Starting Page	61786
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	4
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-04-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Motor Subtype as a Predictor of Future Working Memory Performance in Idiopathic Parkinson's Disease

Motor Skill Learning, Retention, and Control Deficits in Parkinson's Disease

Quantifying the Reconfiguration of Intrinsic Networks during Working Memory

Differential Neural Activation Patterns in Patients with Parkinson's Disease and Freezing of Gait in Response to Concurrent Cognitive and Motor Load

Unbiased and Mobile Gait Analysis Detects Motor Impairment in Parkinson's Disease

Differential Effects of Parkinson's Disease and Dopamine Replacement on Memory Encoding and Retrieval

Tau Reduction Does Not Prevent Motor Deficits in Two Mouse Models of Parkinson's Disease

Altered Small-World Brain Networks in Schizophrenia Patients during Working Memory Performance

Pre-Fibrillar α-Synuclein Mutants Cause Parkinson's Disease-Like Non-Motor Symptoms in Drosophila

Diminished Activation of Motor Working-Memory Networks in Parkinson's Disease

Similar Documents

Motor Subtype as a Predictor of Future Working Memory Performance in Idiopathic Parkinson's Disease

Motor Skill Learning, Retention, and Control Deficits in Parkinson's Disease

Quantifying the Reconfiguration of Intrinsic Networks during Working Memory

Differential Neural Activation Patterns in Patients with Parkinson's Disease and Freezing of Gait in Response to Concurrent Cognitive and Motor Load

Unbiased and Mobile Gait Analysis Detects Motor Impairment in Parkinson's Disease

Differential Effects of Parkinson's Disease and Dopamine Replacement on Memory Encoding and Retrieval

Tau Reduction Does Not Prevent Motor Deficits in Two Mouse Models of Parkinson's Disease

Altered Small-World Brain Networks in Schizophrenia Patients during Working Memory Performance

Pre-Fibrillar α-Synuclein Mutants Cause Parkinson's Disease-Like Non-Motor Symptoms in Drosophila

Diminished Activation of Motor Working-Memory Networks in Parkinson's Disease