NDLI: Successful management of immunological rejection following allogeneic simple limbal epithelial transplantation (SLET) for bilateral ocular burns

Content Provider	PubMed Central
Author	Bhalekar, Swapnil Basu, Sayan Sangwan, Virender S.
Copyright Year	2013
Abstract	A 41-year-old woman presented with bilateral total limbal stem cell deficiency, one year after chemical injury. She underwent allogeneic simple limbal epithelial transplantation (SLET) from a cadaveric donor in her right eye. One month later her unaided visual acuity (VA) improved to 20/100 from hand-motions. The corneal surface was avascular and epithelialised. Three months later, she presented with acute pain in right eye with peripheral corneal neovascularisation encircling the transplants, engorged and tortuous perilimbal vessels and diffuse epithelial haze. For a diagnosis of allograft rejection, pulse doses of intravenous methyl prednisolone with intensive topical steroids were administered. Her symptoms resolved in a week, confirming the diagnosis. She recovered her pre-rejection VA. She was maintained on systemic immunosuppressive agents. Her ocular surface continues to be stable. This case describes hitherto unknown clinical features of allograft rejection following SLET and emphasises the importance of continued immunosuppression in allogeneic limbal transplantation.
Related Links	http://dx.doi.org/10.1136/bcr-2013-009051
Starting Page	2013009051
File Format	PDF
ISSN	1757790X
e-ISSN	1757790X
Journal	BMJ Case Reports
Volume Number	2013
Language	English
Publisher	BMJ Publishing Group
Publisher Date	2013-03-15
Access Restriction	Open
Rights Holder	BMJ Publishing Group
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine

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