NDLI: A proposed mechanism for promoter-associated DNA rearrangement events at a variant surface glycoprotein gene expression site.

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Unusual aspects of in vitro RNA processing in the 3' regions of the GAL1, GAL7, and GAL10 genes in Saccharomyces cerevisiae.

Regulated expression of a mammalian nonsense suppressor tRNA gene in vivo and in vitro using the lac operator/repressor system.

The spliceosome assembly pathway in mammalian extracts.

Different chromatin structures along the spacers flanking active and inactive Xenopus rRNA genes.

Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.

The ARS consensus sequence is required for chromosomal origin function in Saccharomyces cerevisiae.

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Ectopic recombination within homologous immunoglobulin mu gene constant regions in a mouse hybridoma cell line.

RPC82 encodes the highly conserved, third-largest subunit of RNA polymerase C (III) from Saccharomyces cerevisiae.

Ectopic recombination between Ty elements in Saccharomyces cerevisiae is not induced by DNA damage.

Accumulation of U14 small nuclear RNA in Saccharomyces cerevisiae requires box C, box D, and a 5', 3' terminal stem.

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Mapping of epidermal growth factor-, serum-, and phorbol ester-responsive sequence elements in the c-jun promoter.

Cyclic AMP-dependent protein kinase inhibits the activity of myogenic helix-loop-helix proteins.

Modulation of interferon signaling in human fibroblasts by phorbol esters.

A bipartite suppressor: conjunction of two distinct factor-binding sites is essential for down-regulation in rat epoxide hydrolase gene expression.

Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae.

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Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line.

Examination of the DNA-binding ability of estrogen receptor in whole cells: implications for hormone-independent transactivation and the actions of antiestrogens.

Cutinase in Cryphonectria parasitica, the chestnut blight fungus: suppression of cutinase gene expression in isogenic hypovirulent strains containing double-stranded RNAs.

Purification of splicing factor SF1, a heat-stable protein that functions in the assembly of a presplicing complex.

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Distinct roles for the two cGATA-1 finger domains.

In vivo transcriptional analysis of the TATA-less promoter of the Drosophila melanogaster vermilion gene.

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Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells.

Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts.

Activation of c-Src in cells bearing v-Crk and its suppression by Csk.

Regulation of collagen I gene expression by ras.

Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells.

Localization of a DNA replication origin and termination zone on chromosome III of Saccharomyces cerevisiae.

Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation.

Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation.

Analysis of the defect in DNA end joining in the murine scid mutation.

Maximal serum stimulation of the c-fos serum response element requires both the serum response factor and a novel binding factor, SRE-binding protein.

A proposed mechanism for promoter-associated DNA rearrangement events at a variant surface glycoprotein gene expression site.

cis-acting elements involved in the alternative translation initiation process of human basic fibroblast growth factor mRNA.

GAL11 protein, an auxiliary transcription activator for genes encoding galactose-metabolizing enzymes in Saccharomyces cerevisiae.

Construction of a Bifunctional mRNA in the Mouse by Using the Internal Ribosomal Entry Site of the Encephalomyocarditis Virus

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A proposed mechanism for promoter-associated DNA rearrangement events at a variant surface glycoprotein gene expression site.

Content Provider	PubMed Central
Author	Gottesdiener, K. M. Goriparthi, L. Masucci, J. P. Ploeg, L. H. Van Der
Abstract	The expressed variant cell surface glycoprotein (VSG) gene of the protozoan parasite Trypanosoma brucei is invariably found at one of several telomeric VSG gene expression sites (ESs). The active ES in variant 118 clone 1 is found on a 1.5-Mb chromosome, and the promoter region is located more than 45 kb upstream of the VSG gene. We had previously shown that DNA rearrangement events occurred in the promoter region, specifically at inactivation of this ES (K. M. Gottesdiener, H.-M. Chung, S. L. Brown, M. G.-S. Lee, and L. H. T. Van der Ploeg, Mol. Cell. Biol. 11:2467-2477, 1991). In this report, we describe the cloning of the entire 17-kb promoter region, which revealed the presence of two identical 2.15-kb tandem promoter repeats separated by 13 kb of DNA. The two virtually identical promoter repeats both function efficiently in directing transcription in transient transfection assays in insect-form trypanosomes. We characterized the DNA rearrangement events that occur at ES inactivation, and by studying both of the reciprocal products of this recombination event, we infer that these result from direct (promoter) repeat recombination, formation of heteroduplex DNA, and a reciprocal exchange event that releases a circular DNA as a side product of the reaction. The finding of DNA recombinational events in a region of the VSG gene ES that encodes the promoter(s), and their relatively frequent occurrence at ES inactivation, suggests a possible role in ES control.
Starting Page	4784
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	10
Volume Number	12
Language	English
Publisher Date	1992-10-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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