NDLI: Analgesic and Anti-Inflammatory Activities of the Ethanolic Extract of Artemisia morrisonensis Hayata in Mice

Content Provider	PubMed Central
Author	Chou, Shen-chieh Chiu, Yung-jia Chen, Chao-jung Lin, Ying-chih Wu, Chung-hao Chao, Chien-ti Chang, Ching-wen Peng, Wen-huang
Copyright Year	2012
Abstract	The aim of this study was to investigate the possible analgesic and anti-inflammatory mechanisms of the ethanolic extract of A. morrisonensis Hayata (AMEtOH). Two models were employed for evaluation of the analgesic effects: acetic acid-induced writhing response and formalin-induced paw licking. The results demonstrated that AMEtOH decreased writhing response for both the acetic acid assay and the licking time in the formalin test. The anti-inflammatory effect was evaluated by paw edema of mice induced by λ -carrageenan. AMEtOH significantly decreased induced paw edema three to four hours after λ -carrageenan injection. Additionally, the results indicated that the anti-inflammatory mechanism of AMEtOH may be due to the declined levels of nitric oxide (NO) and malondialdehyde (MDA) in the edematous paw. Furthermore, AMEtOH decreased the tumor necrosis factor-alpha (TNF- α ) and interleukin-6 (IL-6) levels, leading to the reduction of prostaglandins and subsequently alleviated edema. Isolation and purification of the AMEtOH extract determined p-hydroxyacetophenone to be a major component at 130 mg/g of extract. No mortality was observed in the acute toxicity test given at the dose of 10 g/kg. This study demonstrated the possible mechanisms for the analgesic and anti-inflammatory effects of AMEtOH for mice and provided evidence for the ethnobotanical uses of A. morrisonensis in treating inflammatory diseases.
Related Links	http://dx.doi.org/10.1155/2012/138954
Starting Page	138954
File Format	PDF
ISSN	1741427X
e-ISSN	17414288
Journal	Evidence-based Complementary and Alternative Medicine : eCAM
Volume Number	2012
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2012-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Complementary and alternative medicine Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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